Assessment and rehabilitation of neglect using virtual reality: a systematic review

Elisa Pedroli, Silvia Serino, Pietro Cipresso, Federica Pallavicini, Giuseppe Riva, Elisa Pedroli, Silvia Serino, Pietro Cipresso, Federica Pallavicini, Giuseppe Riva

Abstract

After experiencing a stroke in the right hemisphere, almost 50% of patients showed Unilateral Spatial Neglect (USN). In recent decades, Virtual Reality (VR) has been used as an effective tool both for the assessment and rehabilitation of USN. Indeed, this advanced technology allows post-stroke patients to interact with ecological and engaging environments similar to real ones, but in a safe and controlled way. To provide an overview of the most recent VR applications for the assessment and rehabilitation of USN, a systematic review has been carried out. Since 2010, 13 studies have proposed and tested innovative VR tools for USN. After a wide description of the selected studies, we discuss the main features of these VR tools in order to provide crucial indications for future studies, neurorehabilitation interventions, and clinical practice.

Keywords: PRISMA; USN; assessment; rehabilitation; virtual reality.

Figures

Figure 1
Figure 1
Search strategy. A graphical representation.
Figure 2
Figure 2
Search strategy using “Virtual Reality” term.
Figure 3
Figure 3
Search strategy using “Technolog*” term.

References

    1. Agrell B. M., Dehlin O. I., Dahlgren C. J. (1997). Neglect in elderly stroke patients: a comparison of five tests. Psychiatry Clin. Neurosci. 51, 295–300. 10.1111/j.1440-1819.1997.tb03201.x
    1. Albert M. L. (1973). A simple test of visual neglect. Neurology 23, 658–664. 10.1212/WNL.23.6.658
    1. Appelros P., Karlsson G. M., Seiger A., Nydevik I. (2002). Neglect and anosognosia after first-ever stroke: incidence and relationship to disability. J. Rehabil. Med. 34, 215–220. 10.1080/165019702760279206
    1. Aravind G., Darekar A., Fung J., Lamontagne A. (2015). Virtual reality-based navigation task to reveal obstacle avoidance performance in individuals with visuospatial neglect. IEEE Trans. Neural Syst. Rehabil. Eng. 23, 179–188. 10.1109/TNSRE.2014.2369812
    1. Aravind G., Lamontagne A. (2014). Perceptual and locomotor factors affect obstacle avoidance in persons with visuospatial neglect. J. Neuroeng. Rehabil. 11:38. 10.1186/1743-0003-11-38
    1. Army Individual Test Battery (1944). Manual of Directions and Scoring. Washington, DC: War Department, Adjutant General's Office.
    1. Azouvi P., Bartolomeo P., Beis J. M., Perennou D., Pradat-Diehl P., Rousseaux M. (2006). A battery of tests for the quantitative assessment of unilateral neglect. Restor. Neurol. Neurosci. 24, 273–285.
    1. Azouvi P., Olivier S., de Montety G., Samuel C., Louis-Dreyfus A., Tesio L. (2003). Behavioral assessment of unilateral neglect: study of the psychometric properties of the Catherine Bergego Scale. Arch. Phys. Med. Rehabil. 84, 51–57. 10.1053/apmr.2003.50062
    1. Bartolomeo P., Chokron S. (2002). Orienting of attention in left unilateral neglect. Neurosci. Biobehav. Rev. 26, 217–234. 10.1016/S0149-7634(01)00065-3
    1. Bohil C. J., Alicea B., Biocca F. A. (2011). Virtual reality in neuroscience research and therapy. Nat. Rev. Neurosci. 12, 752–762. 10.1038/nrn3122
    1. Bonato M. (2012). Neglect and extinction depend greatly on task demands: a review. Front. Hum. Neurosci. 6:195. 10.3389/fnhum.2012.00195
    1. Bonato M., Deouell L. Y. (2013). Hemispatial neglect: computer-based testing allows more sensitive quantification of attentional disorders and recovery and might lead to better evaluation of rehabilitation. Front. Hum. Neurosci. 7:162. 10.3389/fnhum.2013.00162
    1. Bonato M., Priftis K., Marenzi R., Umiltà C., Zorzi M. (2012). Deficits of contralesional awareness: a case study on what paper-and-pencil tests neglect. Neuropsychology 26, 20. 10.1037/a0025306
    1. Bouchard S., Bernier F., Boivin É., Dumoulin S., Laforest M., Guitard T., et al. . (2013). Empathy toward virtual humans depicting a known or unknown person expressing pain. Cyberpsychol. Behav. Soc. Netw. 16, 61–71. 10.1089/cyber.2012.1571
    1. Bowen A., Hazelton C., Pollock A., Lincoln N. B. (2013). Cognitive rehabilitation for spatial neglect following stroke. Cochrane Database Syst. Rev. 7:CD0035860 10.1002/14651858.CD003586.pub3
    1. Bowen A., McKenna K., Tallis R. C. (1999). Reasons for variability in the reported rate of occurrence of unilateral spatial neglect after stroke. Stroke 30, 1196–1202. 10.1161/01.STR.30.6.1196
    1. Brochard S., Robertson J., Médée B., Rémy-Néris O. (2010). What's new in new technologies for upper extremity rehabilitation? Curr. Opin. Neurol. 23, 683–687. 10.1097/WCO.0b013e32833f61ce
    1. Brooks B. M., Rose F. D. (2003). The use of virtual reality in memory rehabilitation: Current findings and future directions. NeuroRehabilitation 18, 147–157.
    1. Butter C. M., Kirsch N. L., Reeves G. (1990). The effect of lateralized dynamic stimuli on unilateral spatial neglect following right hemisphere lesions. Restor. Neurol. Neurosci. 2, 39–46.
    1. Buxbaum L. J., Dawson A. M., Linsley D. (2012). Reliability and validity of the Virtual Reality Lateralized Attention Test in assessing hemispatial neglect in right-hemisphere stroke. Neuropsychology 26, 430. 10.1037/a0028674
    1. Buxbaum L. J., Ferraro M. K., Veramonti T., Farne A., Whyte J., Ladavas E., et al. . (2004). Hemispatial neglect: subtypes, neuroanatomy, and disability. Neurology 62, 749–756. 10.1212/01.WNL.0000113730.73031.F4
    1. Buxbaum L. J., Palermo M. A., Mastrogiovanni D., Read M. S., Rosenberg-Pitonyak E., Rizzo A. A., et al. . (2008). Assessment of spatial attention and neglect with a virtual wheelchair navigation task. J. Clin. Exp. Neuropsychol. 30, 650–660. 10.1080/13803390701625821
    1. Cocchini G., Beschin N., Jehkonen M. (2001). The fluff test: a simple task to assess body representation neglect. Neuropsychol. Rehabil. 11, 17–31. 10.1080/09602010042000132
    1. Colarusso R. P., Hammill D. D. (1972). Motor-free Visual Perception Test. Novato, CA: Academic; Therapy Pub.
    1. Corbetta M., Shulman G. L. (2011). Spatial neglect and attention networks. Annu. Rev. Neurosci. 34, 569. 10.1146/annurev-neuro-061010-113731
    1. Corbetta M., Kincade M. J., Lewis C., Snyder A. Z., Sapir A. (2005). Neural basis and recovery of spatial attention deficits in spatial neglect. Nat. Neurosci. 8, 1603–1610. 10.1038/nn1574
    1. Dalmaijer E. S., Van der Stigchel S., Nijboer T. C., Cornelissen T. H., Husain M. (2014). CancellationTools: All-in-one software for administration and analysis of cancellation tasks. Behav. Res. Methods. 10.3758/s13428-014-0522-7[Epub ahead of print].
    1. DE RENZI E., VIGNOLO L. A. (1962). The token test: a sensitive test to detect receptive disturbances in aphasics. Brain 85, 665. 10.1093/brain/85.4.665
    1. Deouell L. Y., Sacher Y., Soroker N. (2005). Assessment of spatial attention after brain damage with a dynamic reaction time test. J. Int. Neuropsychol. Soc. 11, 697–707. 10.1017/s1355617705050824
    1. Di Carlo A. (2009). Human and economic burden of stroke. Age Ageing 38, 4–5. 10.1093/ageing/afn282
    1. Diller L., Weinberg J. (1976). Hemi-inattention in rehabilitation: the evolution of a rational remediation program. Adv. Neurol. 18, 63–82.
    1. Dvorkin A. Y., Rymer W. Z., Settle K., Patton J. L. (2007). Perceptual assessment of spatial neglect within a virtual environment, in Paper Presented at the Virtual Rehabilitation (Venice: ).
    1. Eslinger P. J., Flaherty-Craig C. V., Benton A. L. (2004). Developmental outcomes after early prefrontal cortex damage. Brain Cogn. 55, 84–103. 10.1016/S0278-2626(03)00281-1
    1. Eslinger P. J., Grattan L. M., Damasio H., Damasio A. R. (1992). Developmental consequences of childhood frontal lobe damage. Arch. Neurol. 49, 764–769. 10.1001/archneur.1992.00530310112021
    1. Folstein M. F., Robins L. N., Helzer J. E. (1983). The Mini-mental state examination. Arch. Gen. Psychiatry 40, 812. 10.1001/archpsyc.1983.01790060110016
    1. Fordell H., Bodin K., Bucht G., Malm J. (2011). A virtual reality test battery for assessment and screening of spatial neglect. Acta Neurol. Scand. 123, 167–174. 10.1111/j.1600-0404.2010.01390.x
    1. Gauthier L., Dehaut F., Joanette Y. (1989). The bells test: a quantitative and qualitative test for visual neglect. Int. J. Clin. Neuropsychol. 11, 49–54.
    1. Geeraerts S., Lafosse C., Vandenbussche E., Verfaillie K. (2005). A psychophysical study of visual extinction: ipsilesional distractor interference with contralesional orientation thresholds in visual hemineglect patients. Neuropsychologia 43, 530–541. 10.1016/j.neuropsychologia.2004.07.012
    1. Gontkovsky S. T., McDonald N. B., Clark P. G., Ruwe W. D. (2002). Current directions in computer-assisted cognitive rehabilitation. NeuroRehabilitation 17, 195–199.
    1. Hackett M. L., Yapa C., Parag V., Anderson C. S. (2005). Frequency of depression after stroke a systematic review of observational studies. Stroke 36, 1330–1340. 10.1161/01.STR.0000165928.19135.35
    1. Halligan P. W., Fink G. R., Marshall J. C., Vallar G. (2003). Spatial cognition: evidence from visual neglect. Trends Cogn. Sci. 7, 125–133. 10.1016/S1364-6613(03)00032-9
    1. Halligan P. W., Marshall J. C., Wade D. T. (1989). Visuospatial neglect: underlying factors and test sensitivity. Lancet 334, 908–911. 10.1016/S0140-6736(89)91561-4
    1. Heilman K. M., Watson R. T., Valenstein E. (1985). Neglect and Related Disorders. New York, NY: Oxford University Press.
    1. Hendricks H. T., van Limbeek J., Geurts A. C., Zwarts M. J. (2002). Motor recovery after stroke: a systematic review of the literature. Arch. Phys. Med. Rehabil. 83, 1629–1637. 10.1053/apmr.2002.35473
    1. Jacquin-Courtois S., O'shea J., Luauté J., Pisella L., Revol P., Mizuno K., et al. . (2013). Rehabilitation of spatial neglect by prism adaptation: a peculiar expansion of sensorimotor after-effects to spatial cognition. Neurosci. Biobehav. Rev. 37, 594–609. 10.1016/j.neubiorev.2013.02.007
    1. Jehkonen M., Laihosalo M., Kettunen J. (2006). Impact of neglect on functional outcome after stroke-a review of methodological issues and recent research findings. Restor. Neurol. Neurosci. 24, 209–215.
    1. Jung H. Y., Park B. K., Shin H. S., Kang Y. K., Pyun S. B., Paik N. J., et al. (2007). Development of the Korean version of Modified Barthel Index (K-MBI): multi-center study for subjects with stroke. J. Korean Acad. Rehabil. Med. 31, 283–297.
    1. Kerkhoff G., Schenk T. (2012). Rehabilitation of neglect: an update. Neuropsychologia 50, 1072–1079. 10.1016/j.neuropsychologia.2012.01.024
    1. Kim D. Y., Ku J., Chang W. H., Park T. H., Lim J. Y., Han K., et al. . (2010). Assessment of post-stroke extrapersonal neglect using a three-dimensional immersive virtual street crossing program. Acta Neurol. Scand. 121, 171–177. 10.1111/j.1600-0404.2009.01194.x
    1. Kim Y. M., Chun M. H., Yun G. J., Song Y. J., Young H. E. (2011). The effect of virtual reality training on unilateral spatial neglect in stroke patients. Ann. Rehabil. Med. 35, 309–315. 10.5535/arm.2011.35.3.309
    1. Làdavas E., Shallice T., Zanella M. T. (1997). Preserved semantic access in neglect dyslexia. Neuropsychologia 35, 257–270. 10.1016/S0028-3932(96)00066-8
    1. Langhorne P., Coupar F., Pollock A. (2009). Motor recovery after stroke: a systematic review. Lancet Neurol. 8, 741–754. 10.1016/S1474-4422(09)70150-4
    1. Leigh S., Danckert J., Eliasmith C. (2015). Modelling the differential effects of prisms on perception and action in neglect. Exp. Brain Res. 233, 751–766. 10.1007/s00221-014-4150-3
    1. Levick W. R. (2010). Observer rating of memory in children: a review. Brain Impair. 11, 144–151. 10.1375/brim.11.2.144
    1. Lindell A. B., Jalas M. J., Tenovuo O., Brunila T., Voeten M. J., Hämäläinen H. (2007). Clinical assessment of hemispatial neglect: evaluation of different measures and dimensions. Clin. Neuropsychol. 21, 479–497. 10.1080/13854040600630061
    1. Lloyd-Jones D., Adams R., Carnethon M., De Simone G., Ferguson T. B., Flegal K., et al. (2009). Heart disease and stroke statistics–2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 119, 21–181. 10.1161/CIRCULATIONAHA.108.191261
    1. Mainetti R., Sedda A., Ronchetti M., Bottini G., Borghese N. A. (2013). Duckneglect: video-games based neglect rehabilitation. Technol. Health Care 21, 97–111. 10.3233/THC-120712
    1. Mattingley J. B., Bradshaw J. L., Bradshaw J. A. (1994). Horizontal visual motion modulates focal attention in left unilateral spatial neglect. J. Neurol. Neurosurg. Psychiatry 57, 1228–1235. 10.1136/jnnp.57.10.1228
    1. Mesa-Gresa P., Lozano J. A., Llórens R., Alcañiz M., Navarro M. D., Noé E. (2011). Clinical validation of a virtual environment test for safe street crossing in the assessment of acquired brain injury patients with and without neglect, in Paper Presented at the Proceedings of the 13th IFIP TC 13 International Conference on Human-computer Interaction - Volume Part II (Lisbon: ).
    1. Meyerbröker K., Morina N., Kerkhof G., Emmelkamp P. M. (2010). Virtual reality exposure treatment of agoraphobia: a comparison of computer automatic virtual environment and head-mounted display. Stud. Health Technol. Inform. 167, 51–56. 10.3233/978-1-60750-766-6-51
    1. Moher D., Liberati A., Tetzlaff J., Altman D. G., PRISMA Group . (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 6:e1000097. 10.1371/journal.pmed.1000097
    1. Mutai H., Furukawa T., Araki K., Misawa K., Hanihara T. (2012). Factors associated with functional recovery and home discharge in stroke patients admitted to a convalescent rehabilitation ward. Geriatr. Gerontol. Int. 12, 215–222. 10.1111/j.1447-0594.2011.00747.x
    1. Nasreddine Z. S., Phillips N. A., Bédirian V., Charbonneau S., Whitehead V., Collin I., et al. . (2005). The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J. Am. Geriatr. Soc. 53, 695–699. 10.1111/j.1532-5415.2005.53221.x
    1. Navarro M. D., Lloréns R., Noé E., Ferri J., Alcañiz M. (2013). Validation of a low-cost virtual reality system for training street-crossing. A comparative study in healthy, neglected and non-neglected stroke individuals. Neuropsychol. Rehabil. 23, 597–618. 10.1080/09602011.2013.806269
    1. Newport R., Schenk T. (2012). Prisms and neglect: what have we learned? Neuropsychologia 50, 1080–1091. 10.1016/j.neuropsychologia.2012.01.023
    1. Nijboer T. C., Kollen B. J., Kwakkel G. (2013a). Time course of visuospatial neglect early after stroke: a longitudinal cohort study. Cortex 49, 2021–2027. 10.1016/j.cortex.2012.11.006
    1. Nijboer T. C. W., Kollen B. J., Kwakkel G. (2014a). The impact of recovery of visuo-spatial neglect on motor recovery of the upper paretic limb after stroke. PLoS ONE 9:e100584. 10.1371/journal.pone.0100584
    1. Nijboer T. C. W., Ten Brink A. F., Kouwenhoven M., Visser-Meily J. M. A. (2014b). Functional assessment of region-specific neglect: are there differential behavioural consequences of peripersonal versus extrapersonal neglect? Behav. Neurol. 2014:526407. 10.1155/2014/526407
    1. Nijboer T. C., van de Port I., Schepers V., Post M., Visser-Meily A. (2013b). Predicting functional outcome after stroke: the influence of neglect on basic activities in daily living. Front. Hum. Neurosci. 7:182. 10.3389/fnhum.2013.00182
    1. Paci M., Matulli G., Baccini M., Rinaldi L. A., Baldassi S. (2010). Reported quality of randomized controlled trials in neglect rehabilitation. Neurol. Sci. 31, 159–163. 10.1007/s10072-009-0198-4
    1. Peña-Casanova J., Gramunt Fombuena N., Gich Fullà J. (2006). Neurophychological Tests. Barcelona: Elsevier.
    1. Pendlebury S. T., Giles M. F., Rothwell P. M. (2009). Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Management. Cambridge: Cambridge University Press.
    1. Perez-Garcia M., Godoy-Garcia J. F., Vera-Guerrero N., Laserna-Triguero J. A., Ouente A. E. (1998). Neuropsychological evaluation of everyday memory. Neuropsychol. Rev. 8, 203–227. 10.1023/A:1021622319851
    1. Perez-Marcos D., Solazzi M., Steptoe W., Oyekoya O., Frisoli A., Weyrich T., et al. . (2012). A fully-immersive set-up for remote interaction and neurorehabilitation based on virtual body ownership. Front. Neurol. 3:110. 10.3389/fneur.2012.00110
    1. Peskine A., Rosso C., Box N., Galland A., Caron E., Rautureau G., et al. . (2011). Virtual reality assessment for visuospatial neglect: importance of a dynamic task. J. Neurol. Neurosurg. Psychiatr. 82, 1407–1409. 10.1136/jnnp.2010.217513
    1. Pflugshaupt T., Bopp S. A., Heinemann D., Mosimann U. P., von Wartburg R., Nyffeler T., et al. . (2004). Residual oculomotor and exploratory deficits in patients with recovered hemineglect. Neuropsychologia 42, 1203–1211. 10.1016/j.neuropsychologia.2004.02.002
    1. Pierce S. R., Buxbaum L. J. (2002). Treatments of unilateral neglect: a review. Arch. Phys. Med. Rehabil. 83, 256–268. 10.1053/apmr.2002.27333
    1. Pizzamiglio L. (1990). La Rieducazione Dell'Eminattenzione Spaziale. Milano: Masson Ed.
    1. Pohjasvaara T., Leskelä M., Vataja R., Kalska H., Ylikoski R., Hietanen M., et al. . (2002). Post−stroke depression, executive dysfunction and functional outcome. Eur. J. Neurol. 9, 269–275. 10.1046/j.1468-1331.2002.00396.x
    1. Rabuffetti M., Farina E., Alberoni M., Pellegatta D., Appollonio I., Affanni P., et al. . (2012). Spatio-temporal features of visual exploration in unilaterally brain-damaged subjects with or without neglect: results from a touchscreen test. PLoS ONE 7:e31511. 10.1371/annotation/bf311a56-bc48-44b6-9b0f-7ccc97fc290f
    1. Rengachary J., d'Avossa G., Sapir A., Shulman G. L., Corbetta M. (2009). Is the posner reaction time test more accurate than clinical tests in detecting left neglect in acute and chronic stroke? Arch. Phys. Med. Rehabil. 90, 2081–2088. 10.1016/j.apmr.2009.07.014
    1. Riva G. (2009). Virtual reality: an experiential tool for clinical psychology. Br. J. Guid. Couns. 37, 337–345. 10.1080/03069880902957056
    1. Riva G., Castelnuovo G., Mantovani F. (2006). Transformation of flow in rehabilitation: the role of advanced communication technologies. Behav. Res. Methods 38, 237–244. 10.3758/BF03192775
    1. Riva G., Mantovani F., Gaggioli A. (2004). Presence and rehabilitation: toward second-generation virtual reality applications in neuropsychology. J. Neuroeng. Rehabil. 1, 9. 10.1186/1743-0003-1-9
    1. Rizzo A. A., Buckwalter J. G., van der Zaag C. (2002). Applications for neuropsychological assessment and rehabilitation, in Handbook of Virtual Environments, ed Stanney K. (New York, NY: L. A. Earlbaum; ), 1027–1064.
    1. Robertson I. H., Halligan P. W. (1999). Spatial Neglect: A Clinical Handbook for Diagnosis and Treatment. Hove: Psychology Press.
    1. Rossetti Y., Rode G., Pisella L., Farné A., Li L., Boisson D., et al. . (1998). Prism adaptation to a rightward optical deviation rehabilitates left hemispatial neglect. Nature 395, 166–169. 10.1038/25988
    1. Schenkenberg T., Bradford D. C., Ajax E. T. (1980). Line bisection and unilateral visual neglect in patients with neurologic impairment. Neurology 30, 509–509. 10.1212/WNL.30.5.509
    1. Schultheis M. T., Rizzo A. A. (2001). The application of virtual reality technology in rehabilitation. Rehabil. Psychol. 46, 296 10.1037/0090-5550.46.3.296
    1. Sedda A., Borghese N. A., Ronchetti M., Mainetti R., Pasotti F., Beretta G., et al. . (2013). Using virtual reality to rehabilitate neglect. Behav. Neurol. 26, 183–185. 10.1155/2013/810279
    1. Smania N., Martini M., Gambina G., Tomelleri G., Palamara A., Natale E., et al. . (1998). The spatial distribution of visual attention in hemineglect and extinction patients. Brain 121, 1759–1770. 10.1093/brain/121.9.1759
    1. Smit M., Van der Stigchel S., Visser-Meily J. M., Kouwenhoven M., Eijsackers A. L., Nijboer T. C. (2013). The feasibility of computer-based prism adaptation to ameliorate neglect in sub-acute stroke patients admitted to a rehabilitation center. Front. Hum. Neurosci. 7:353. 10.3389/fnhum.2013.00353
    1. Spinnler H., Tognoni G. (1987). Standardizzazione e Taratura Italiana di Test Neuropsicologici. Milano: Masson Italia Periodici.
    1. Sudlow C. L. M., Warlow C. P. (1997). Comparable studies of the incidence of stroke and its pathological types - Results from am international collaboration. Stroke 28, 491–499. 10.1161/01.STR.28.3.491
    1. Sugarman H., Weisel-Eichler A., Burstin A., Brown R. (2011). Use of novel virtual reality system for the assessment and treatment of unilateral spatial neglect: A feasibility study, in Paper Presented 2011 International Conference on the Virtual Rehabilitation (ICVR) (Zurich: ). 10.1109/ICVR.2011.5971859
    1. Sundar U., Adwani S. (2010). Post-stroke cognitive impairment at 3 months. Ann. Indian Acad. Neurol. 13, 42. 10.4103/0972-2327.61276
    1. Tanaka T., Ifukube T., Sugihara S., Izumi T. (2010). A case study of new assessment and training of unilateral spatial neglect in stroke patients: effect of visual image transformation and visual stimulation by using a head mounted display system (HMD). J. Neuroeng. Rehabil. 7:20. 10.1186/1743-0003-7-20
    1. Tant M. L. M., Kuks J. M. B., Kooijman A. C., Cornelissen F. W., Brouwer W. H. (2002). Grey scales uncover similar attentional effects in homonymous hemianopia and visual neglect. Neuropsychologia 40, 1474–1481. 10.1016/S0028-3932(01)00197-X
    1. Tham K. (1996). The baking tray task: a test of spatial neglect. Neuropsychol. Rehabil. 6, 19–26. 10.1080/713755496
    1. Tham K., Tegnér R. (1996). The baking tray task: a test of spatial neglect. Neuropsychol. Rehabil. 6, 19–25. 10.1080/713755496
    1. Towle D., Lincoln N. B. (1991). Development of a questionnaire for detecting everyday problems in stroke patients with unilateral neglect. Clin. Rehabil. 5, 135–140. 10.1177/026921559100500208
    1. Tsirlin I., Dupierrix E., Chokron S., Coquillart S., Ohlmann T. (2009). Uses of virtual reality for diagnosis, rehabilitation and study of unilateral spatial neglect: review and analysis. Cyberpsychol. Behav. 12, 175–181. 10.1089/cpb.2008.0208
    1. Vaes N., Lafosse C., Nys G., Schevernels H., Dereymaeker L., Oostra K., et al. . (2015). Capturing peripersonal spatial neglect: An electronic method to quantify visuospatial processes. Behav. Res. Methods 47, 27–44. 10.3758/s13428-014-0448-0
    1. Vallar G., Perani D. (1986). The anatomy of unilateral neglect after right-hemisphere stroke lesions. A clinical/CT-scan correlation study in man. Neuropsychologia 24, 609–622. 10.1016/0028-3932(86)90001-1
    1. van Kessel M. E., Geurts A. C., Brouwer W. H., Fasotti L. (2013). Visual scanning training for neglect after stroke with and without a computerized lane tracking dual task. Front. Hum. Neurosci. 7:358. 10.3389/fnhum.2013.00358
    1. Vriezen E. R., Pigott S. D., Pelletier P. M. (2001). Developmental implications of early frontal-lobe damage: a case study. Brain Cogn. 47, 222–225.
    1. Wilson B., Cockburn J., Halligan P. (1987). Development of a behavioral test of visuospatial neglect. Arch. Phys. Med. Rehabil. 68, 98–102.
    1. Witmer B., Singer M. (1998). Measuring presence in virtual environments: a presence questionnaire. Presence 7, 225–240. 10.1162/105474698565686
    1. Wolfe C. D. A. (2000). The impact of stroke. Br. Med. Bull. 56, 275–286. 10.1258/0007142001903120
    1. Yong Joo L., Soon Yin T., Xu D., Thia E., Pei Fen C., Kuah C. W., et al. . (2010). A feasibility study using interactive commercial off-the-shelf computer gaming in upper limb rehabilitation in patients after stroke. J. Rehabil. Med. 42, 437–441. 10.2340/16501977-0528
    1. Zhang Y., Chapman A. M., Plested M., Jackson D., Purroy F. (2012). The incidence, prevalence, and mortality of stroke in France, Germany, Italy, Spain, the UK, and the US: a literature review. Stroke Res. Treat. 2012:436125. 10.1155/2012/436125
    1. Zoccolotti P., Antonucci G., Judica A. (1992). Psychometric characteristics of two semi-structured scales for the functional evaluation of hemi-inattention in extrapersonal and personal space. Neuropsychol. Rehabil. 2, 179–191. 10.1080/09602019208401407

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