Increased placental nutrient transport in a novel mouse model of maternal obesity with fetal overgrowth
Fredrick J Rosario, Yoshikatsu Kanai, Theresa L Powell, Thomas Jansson, Fredrick J Rosario, Yoshikatsu Kanai, Theresa L Powell, Thomas Jansson
Abstract
Objective: To identify possible mechanisms linking obesity in pregnancy to increased fetal adiposity and growth, a unique mouse model of maternal obesity associated with fetal overgrowth was developed, and the hypothesis that maternal obesity causes up-regulation of placental nutrient transporter expression and activity was tested.
Methods: C57BL/6J female mice were fed a control (C) or a high-fat/high-sugar (HF/HS) pelleted diet supplemented by ad libitum access to sucrose (20%) solution, mated, and studied at embryonic day 18.5.
Results: HF/HS diet increased maternal fat mass by 2.2-fold (P < 0.01) and resulted in glucose intolerance with normal fasting glucose. Maternal circulating insulin, leptin, and cholesterol were increased (P < 0.05) whereas total and high-molecular-weight adiponectin was decreased (P < 0.05). HF/HS diet increased fetal weight (+18%, P = 0.0005). In trophoblast plasma membranes (TPM) isolated from placentas of HF/HS-fed animals, protein expression of glucose transporter (GLUT) 1 and 3, sodium-coupled neutral amino acid transporter (SNAT) 2, and large neutral amino acid transporter 1 (LAT1) was increased. TPM System A and L amino acid transporter activity was increased in the HF/HS group.
Conclusions: Up-regulation of specific placental nutrient transporter isoforms may constitute a mechanism underlying fetal overgrowth in maternal obesity.
© 2015 The Obesity Society.
Figures
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4509489/bin/nihms-690545-f0001.jpg)
Figure 2
Daily calorie (A) and food…
Figure 2
Daily calorie (A) and food intake (B) in pregnant mice fed control (n=15)…
Figure 3
Maternal glucose tolerance test (A)…
Figure 3
Maternal glucose tolerance test (A) at E18.5 after a 4-hour fast in mice…
Figure 4
Fetal (A) and placental (B)…
Figure 4
Fetal (A) and placental (B) weights determined at E18.5 in mice fed a…
Figure 5
TPM nutrient transporter isoform expression…
Figure 5
TPM nutrient transporter isoform expression (A-F) and activity (G-H). A and B). Protein…
- Activation of placental insulin and mTOR signaling in a mouse model of maternal obesity associated with fetal overgrowth.Rosario FJ, Powell TL, Jansson T. Rosario FJ, et al. Am J Physiol Regul Integr Comp Physiol. 2016 Jan 1;310(1):R87-93. doi: 10.1152/ajpregu.00356.2015. Epub 2015 Oct 21. Am J Physiol Regul Integr Comp Physiol. 2016. PMID: 26491103 Free PMC article.
- High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice.Jones HN, Woollett LA, Barbour N, Prasad PD, Powell TL, Jansson T. Jones HN, et al. FASEB J. 2009 Jan;23(1):271-8. doi: 10.1096/fj.08-116889. Epub 2008 Sep 30. FASEB J. 2009. PMID: 18827021 Free PMC article.
- Choline prevents fetal overgrowth and normalizes placental fatty acid and glucose metabolism in a mouse model of maternal obesity.Nam J, Greenwald E, Jack-Roberts C, Ajeeb TT, Malysheva OV, Caudill MA, Axen K, Saxena A, Semernina E, Nanobashvili K, Jiang X. Nam J, et al. J Nutr Biochem. 2017 Nov;49:80-88. doi: 10.1016/j.jnutbio.2017.08.004. Epub 2017 Aug 12. J Nutr Biochem. 2017. PMID: 28915389 Free PMC article.
- Increased placental fatty acid transporter 6 and binding protein 3 expression and fetal liver lipid accumulation in a mouse model of obesity in pregnancy.Díaz P, Harris J, Rosario FJ, Powell TL, Jansson T. Díaz P, et al. Am J Physiol Regul Integr Comp Physiol. 2015 Dec 15;309(12):R1569-77. doi: 10.1152/ajpregu.00385.2015. Epub 2015 Oct 21. Am J Physiol Regul Integr Comp Physiol. 2015. PMID: 26491104 Free PMC article.
- Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth.Aye IL, Rosario FJ, Powell TL, Jansson T. Aye IL, et al. Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12858-63. doi: 10.1073/pnas.1515484112. Epub 2015 Sep 28. Proc Natl Acad Sci U S A. 2015. PMID: 26417088 Free PMC article.
- Role of Obesity in Female Reproduction.Yong W, Wang J, Leng Y, Li L, Wang H. Yong W, et al. Int J Med Sci. 2023 Jan 31;20(3):366-375. doi: 10.7150/ijms.80189. eCollection 2023. Int J Med Sci. 2023. PMID: 36860674 Free PMC article. Review.
- Severe gestational diabetes mellitus in lean dams is associated with low IL-1α levels and affects the growth of the juvenile mouse offspring.Mihalovičová L, Kunšteková V, Miláček D, Janko J, Pastorek M, Konečná B, Gurecká R, Rausová Z, Uličná O, Celec P, Šebeková K. Mihalovičová L, et al. Sci Rep. 2023 Jan 30;13(1):1700. doi: 10.1038/s41598-023-28903-7. Sci Rep. 2023. PMID: 36717684 Free PMC article.
- Female and male C57BL/6J offspring exposed to maternal obesogenic diet develop altered hypothalamic energy metabolism in adulthood.Kulhanek D, Abrahante Llorens JE, Buckley L, Tkac I, Rao R, Paulsen ME. Kulhanek D, et al. Am J Physiol Endocrinol Metab. 2022 Nov 1;323(5):E448-E466. doi: 10.1152/ajpendo.00100.2022. Epub 2022 Sep 21. Am J Physiol Endocrinol Metab. 2022. PMID: 36342228
- Association between High-Fat Diet during Pregnancy and Heart Weight of the Offspring: A Multivariate and Mediation Analysis.Wang W, Huo Y, Zhang J, Xu D, Bai F, Gui Y. Wang W, et al. Nutrients. 2022 Oct 11;14(20):4237. doi: 10.3390/nu14204237. Nutrients. 2022. PMID: 36296921 Free PMC article.
- Maternal obesity and the impact of associated early-life inflammation on long-term health of offspring.Denizli M, Capitano ML, Kua KL. Denizli M, et al. Front Cell Infect Microbiol. 2022 Sep 16;12:940937. doi: 10.3389/fcimb.2022.940937. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 36189369 Free PMC article. Review.
-
- Catalano PM. Obesity and pregnancy - the propagation of a viscous cycle? J Clin Endocrinol Metab. 2003;88:3505–3506. - PubMed
-
- Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of obesity in the United States, 2009-2010. NCHS Data Brief. 2012:1–8. - PubMed
-
- Heslehurst N, Rankin J, Wilkinson JR, Summerbell CD. A nationally representative study of maternal obesity in England, UK: trends in incidence and demographic inequalities in 619 323 births, 1989-2007. International journal of obesity. 2010;34:420–428. - PubMed
- Research Support, N.I.H., Extramural
- Animals
- Disease Models, Animal
- Female
- Fetal Weight / genetics*
- Insulin / blood*
- Leptin / metabolism*
- Mice
- Mice, Inbred C57BL
- Mothers
- Obesity / complications*
- Obesity / physiopathology
- Pregnancy
- Up-Regulation
- Weight Gain / physiology*
- Insulin
- Leptin
- Full Text Sources
- Other Literature Sources
- Medical
- Research Materials
- Miscellaneous
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
![Figure 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4509489/bin/nihms-690545-f0002.jpg)
Figure 3
Maternal glucose tolerance test (A)…
Figure 3
Maternal glucose tolerance test (A) at E18.5 after a 4-hour fast in mice…
Figure 4
Fetal (A) and placental (B)…
Figure 4
Fetal (A) and placental (B) weights determined at E18.5 in mice fed a…
Figure 5
TPM nutrient transporter isoform expression…
Figure 5
TPM nutrient transporter isoform expression (A-F) and activity (G-H). A and B). Protein…
- Activation of placental insulin and mTOR signaling in a mouse model of maternal obesity associated with fetal overgrowth.Rosario FJ, Powell TL, Jansson T. Rosario FJ, et al. Am J Physiol Regul Integr Comp Physiol. 2016 Jan 1;310(1):R87-93. doi: 10.1152/ajpregu.00356.2015. Epub 2015 Oct 21. Am J Physiol Regul Integr Comp Physiol. 2016. PMID: 26491103 Free PMC article.
- High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice.Jones HN, Woollett LA, Barbour N, Prasad PD, Powell TL, Jansson T. Jones HN, et al. FASEB J. 2009 Jan;23(1):271-8. doi: 10.1096/fj.08-116889. Epub 2008 Sep 30. FASEB J. 2009. PMID: 18827021 Free PMC article.
- Choline prevents fetal overgrowth and normalizes placental fatty acid and glucose metabolism in a mouse model of maternal obesity.Nam J, Greenwald E, Jack-Roberts C, Ajeeb TT, Malysheva OV, Caudill MA, Axen K, Saxena A, Semernina E, Nanobashvili K, Jiang X. Nam J, et al. J Nutr Biochem. 2017 Nov;49:80-88. doi: 10.1016/j.jnutbio.2017.08.004. Epub 2017 Aug 12. J Nutr Biochem. 2017. PMID: 28915389 Free PMC article.
- Increased placental fatty acid transporter 6 and binding protein 3 expression and fetal liver lipid accumulation in a mouse model of obesity in pregnancy.Díaz P, Harris J, Rosario FJ, Powell TL, Jansson T. Díaz P, et al. Am J Physiol Regul Integr Comp Physiol. 2015 Dec 15;309(12):R1569-77. doi: 10.1152/ajpregu.00385.2015. Epub 2015 Oct 21. Am J Physiol Regul Integr Comp Physiol. 2015. PMID: 26491104 Free PMC article.
- Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth.Aye IL, Rosario FJ, Powell TL, Jansson T. Aye IL, et al. Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12858-63. doi: 10.1073/pnas.1515484112. Epub 2015 Sep 28. Proc Natl Acad Sci U S A. 2015. PMID: 26417088 Free PMC article.
- Role of Obesity in Female Reproduction.Yong W, Wang J, Leng Y, Li L, Wang H. Yong W, et al. Int J Med Sci. 2023 Jan 31;20(3):366-375. doi: 10.7150/ijms.80189. eCollection 2023. Int J Med Sci. 2023. PMID: 36860674 Free PMC article. Review.
- Severe gestational diabetes mellitus in lean dams is associated with low IL-1α levels and affects the growth of the juvenile mouse offspring.Mihalovičová L, Kunšteková V, Miláček D, Janko J, Pastorek M, Konečná B, Gurecká R, Rausová Z, Uličná O, Celec P, Šebeková K. Mihalovičová L, et al. Sci Rep. 2023 Jan 30;13(1):1700. doi: 10.1038/s41598-023-28903-7. Sci Rep. 2023. PMID: 36717684 Free PMC article.
- Female and male C57BL/6J offspring exposed to maternal obesogenic diet develop altered hypothalamic energy metabolism in adulthood.Kulhanek D, Abrahante Llorens JE, Buckley L, Tkac I, Rao R, Paulsen ME. Kulhanek D, et al. Am J Physiol Endocrinol Metab. 2022 Nov 1;323(5):E448-E466. doi: 10.1152/ajpendo.00100.2022. Epub 2022 Sep 21. Am J Physiol Endocrinol Metab. 2022. PMID: 36342228
- Association between High-Fat Diet during Pregnancy and Heart Weight of the Offspring: A Multivariate and Mediation Analysis.Wang W, Huo Y, Zhang J, Xu D, Bai F, Gui Y. Wang W, et al. Nutrients. 2022 Oct 11;14(20):4237. doi: 10.3390/nu14204237. Nutrients. 2022. PMID: 36296921 Free PMC article.
- Maternal obesity and the impact of associated early-life inflammation on long-term health of offspring.Denizli M, Capitano ML, Kua KL. Denizli M, et al. Front Cell Infect Microbiol. 2022 Sep 16;12:940937. doi: 10.3389/fcimb.2022.940937. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 36189369 Free PMC article. Review.
-
- Catalano PM. Obesity and pregnancy - the propagation of a viscous cycle? J Clin Endocrinol Metab. 2003;88:3505–3506. - PubMed
-
- Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of obesity in the United States, 2009-2010. NCHS Data Brief. 2012:1–8. - PubMed
-
- Heslehurst N, Rankin J, Wilkinson JR, Summerbell CD. A nationally representative study of maternal obesity in England, UK: trends in incidence and demographic inequalities in 619 323 births, 1989-2007. International journal of obesity. 2010;34:420–428. - PubMed
- Research Support, N.I.H., Extramural
- Animals
- Disease Models, Animal
- Female
- Fetal Weight / genetics*
- Insulin / blood*
- Leptin / metabolism*
- Mice
- Mice, Inbred C57BL
- Mothers
- Obesity / complications*
- Obesity / physiopathology
- Pregnancy
- Up-Regulation
- Weight Gain / physiology*
- Insulin
- Leptin
- Full Text Sources
- Other Literature Sources
- Medical
- Research Materials
- Miscellaneous
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
![Figure 3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4509489/bin/nihms-690545-f0003.jpg)
Figure 4
Fetal (A) and placental (B)…
Figure 4
Fetal (A) and placental (B) weights determined at E18.5 in mice fed a…
Figure 5
TPM nutrient transporter isoform expression…
Figure 5
TPM nutrient transporter isoform expression (A-F) and activity (G-H). A and B). Protein…
- Activation of placental insulin and mTOR signaling in a mouse model of maternal obesity associated with fetal overgrowth.Rosario FJ, Powell TL, Jansson T. Rosario FJ, et al. Am J Physiol Regul Integr Comp Physiol. 2016 Jan 1;310(1):R87-93. doi: 10.1152/ajpregu.00356.2015. Epub 2015 Oct 21. Am J Physiol Regul Integr Comp Physiol. 2016. PMID: 26491103 Free PMC article.
- High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice.Jones HN, Woollett LA, Barbour N, Prasad PD, Powell TL, Jansson T. Jones HN, et al. FASEB J. 2009 Jan;23(1):271-8. doi: 10.1096/fj.08-116889. Epub 2008 Sep 30. FASEB J. 2009. PMID: 18827021 Free PMC article.
- Choline prevents fetal overgrowth and normalizes placental fatty acid and glucose metabolism in a mouse model of maternal obesity.Nam J, Greenwald E, Jack-Roberts C, Ajeeb TT, Malysheva OV, Caudill MA, Axen K, Saxena A, Semernina E, Nanobashvili K, Jiang X. Nam J, et al. J Nutr Biochem. 2017 Nov;49:80-88. doi: 10.1016/j.jnutbio.2017.08.004. Epub 2017 Aug 12. J Nutr Biochem. 2017. PMID: 28915389 Free PMC article.
- Increased placental fatty acid transporter 6 and binding protein 3 expression and fetal liver lipid accumulation in a mouse model of obesity in pregnancy.Díaz P, Harris J, Rosario FJ, Powell TL, Jansson T. Díaz P, et al. Am J Physiol Regul Integr Comp Physiol. 2015 Dec 15;309(12):R1569-77. doi: 10.1152/ajpregu.00385.2015. Epub 2015 Oct 21. Am J Physiol Regul Integr Comp Physiol. 2015. PMID: 26491104 Free PMC article.
- Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth.Aye IL, Rosario FJ, Powell TL, Jansson T. Aye IL, et al. Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12858-63. doi: 10.1073/pnas.1515484112. Epub 2015 Sep 28. Proc Natl Acad Sci U S A. 2015. PMID: 26417088 Free PMC article.
- Role of Obesity in Female Reproduction.Yong W, Wang J, Leng Y, Li L, Wang H. Yong W, et al. Int J Med Sci. 2023 Jan 31;20(3):366-375. doi: 10.7150/ijms.80189. eCollection 2023. Int J Med Sci. 2023. PMID: 36860674 Free PMC article. Review.
- Severe gestational diabetes mellitus in lean dams is associated with low IL-1α levels and affects the growth of the juvenile mouse offspring.Mihalovičová L, Kunšteková V, Miláček D, Janko J, Pastorek M, Konečná B, Gurecká R, Rausová Z, Uličná O, Celec P, Šebeková K. Mihalovičová L, et al. Sci Rep. 2023 Jan 30;13(1):1700. doi: 10.1038/s41598-023-28903-7. Sci Rep. 2023. PMID: 36717684 Free PMC article.
- Female and male C57BL/6J offspring exposed to maternal obesogenic diet develop altered hypothalamic energy metabolism in adulthood.Kulhanek D, Abrahante Llorens JE, Buckley L, Tkac I, Rao R, Paulsen ME. Kulhanek D, et al. Am J Physiol Endocrinol Metab. 2022 Nov 1;323(5):E448-E466. doi: 10.1152/ajpendo.00100.2022. Epub 2022 Sep 21. Am J Physiol Endocrinol Metab. 2022. PMID: 36342228
- Association between High-Fat Diet during Pregnancy and Heart Weight of the Offspring: A Multivariate and Mediation Analysis.Wang W, Huo Y, Zhang J, Xu D, Bai F, Gui Y. Wang W, et al. Nutrients. 2022 Oct 11;14(20):4237. doi: 10.3390/nu14204237. Nutrients. 2022. PMID: 36296921 Free PMC article.
- Maternal obesity and the impact of associated early-life inflammation on long-term health of offspring.Denizli M, Capitano ML, Kua KL. Denizli M, et al. Front Cell Infect Microbiol. 2022 Sep 16;12:940937. doi: 10.3389/fcimb.2022.940937. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 36189369 Free PMC article. Review.
-
- Catalano PM. Obesity and pregnancy - the propagation of a viscous cycle? J Clin Endocrinol Metab. 2003;88:3505–3506. - PubMed
-
- Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of obesity in the United States, 2009-2010. NCHS Data Brief. 2012:1–8. - PubMed
-
- Heslehurst N, Rankin J, Wilkinson JR, Summerbell CD. A nationally representative study of maternal obesity in England, UK: trends in incidence and demographic inequalities in 619 323 births, 1989-2007. International journal of obesity. 2010;34:420–428. - PubMed
- Research Support, N.I.H., Extramural
- Animals
- Disease Models, Animal
- Female
- Fetal Weight / genetics*
- Insulin / blood*
- Leptin / metabolism*
- Mice
- Mice, Inbred C57BL
- Mothers
- Obesity / complications*
- Obesity / physiopathology
- Pregnancy
- Up-Regulation
- Weight Gain / physiology*
- Insulin
- Leptin
- Full Text Sources
- Other Literature Sources
- Medical
- Research Materials
- Miscellaneous
![Figure 4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4509489/bin/nihms-690545-f0004.jpg)
Figure 5
TPM nutrient transporter isoform expression…
Figure 5
TPM nutrient transporter isoform expression (A-F) and activity (G-H). A and B). Protein…
![Figure 5](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4509489/bin/nihms-690545-f0005.jpg)
References
- Catalano PM, Presley L, Minium J, Hauguel-de Mouzon S. Fetuses of obese mothers develop insulin resistance in utero. Diabetes Care. 2009;32:1076–1080.
- Alfaradhi MZ, Ozanne SE. Developmental programming in response to maternal overnutrition. Front Genet. 2011;2:27.
- Catalano PM. Obesity and pregnancy - the propagation of a viscous cycle? J Clin Endocrinol Metab. 2003;88:3505–3506.
- Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of obesity in the United States, 2009-2010. NCHS Data Brief. 2012:1–8.
- Heslehurst N, Rankin J, Wilkinson JR, Summerbell CD. A nationally representative study of maternal obesity in England, UK: trends in incidence and demographic inequalities in 619 323 births, 1989-2007. International journal of obesity. 2010;34:420–428.
- Jansson T, Ekstrand Y, Bjorn C, Wennergren M, Powell TL. Alterations in the activity of placental amino acid transporters in pregnancies complicated by diabetes. Diabetes. 2002;51:2214–2219.
- Kuruvilla AG, D'Souza SW, Glazier JD, Mahendran D, Maresh MJ, Sibley CP. Altered activity of the system A amino acid transporter in microvillous membrane vesicles from placentas of macrosomic babies born to diabetic women. J Clin Invest. 1994;94:689–695.
- Jansson T, Wennergren M, Powell TL. Placental glucose transport and GLUT 1 expression in insulin-dependent diabetes. Am J Obstet Gynecol. 1999;180:163–168.
- Jansson N, Rosario FJ, Gaccioli F, Lager S, Jones HN, Roos S, et al. Activation of placental mTOR signaling and amino acid transporters in obese women giving birth to large babies. J Clin Endocrinol Metab. 2013;98:105–113.
- Ramsay JE, Ferrell WR, Crawford L, Wallace AM, Greer IA, Sattar N. Maternal obesity is associated with dysregulation of metabolic, vascular and inflammatory pathways. J Clin Endocrinol Metab. 2002;87:4231–4237.
- Jansson N, Nilsfelt A, Gellerstedt M, Wennergren M, Hulthen-Rossander L, Powell TL, et al. Maternal hormones linking maternal bodymass index and dietary intake to birth weight. Am J Clin Nutr. 2008;87:1743–1749.
- Jones HN, Powell TL, Jansson T. Regulation of placental nutrient transport. A review. Placenta. 2007;28:763–774.
- Jansson N, Greenwood SL, Johansson BR, Powell TL, Jansson T. Leptin stimulates the activity of the system A amino acid transporter in human placental villous fragments. J Clin Endocrinol Metab. 2003;88:1205–1211.
- Jones HN, Jansson T, Powell TL. IL-6 stimulates System A amino acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2. Am J Physiol Cell. 2009;297:C1228–1235.
- Jones HN, Jansson T, Powell TL. Full length adiponectin attenuates insulin signaling and inhibits insulin-stimulated amino acid transport in human primary trophoblast cells. Diabetes. 2010;59:1161–1170.
- Samuelsson AM, Morris A, Igosheva N, Kirk SL, Pombo JM, Coen CW, et al. Evidence for sympathetic origins of hypertension in juvenile offspring of obese rats. Hypertension. 2010;55:76–82.
- Zhang L, Long NM, Hein SM, Ma Y, Nathanielsz PW, Ford SP. Maternal obesity in ewes results in reduced fetal pancreatic beta-cell numbers in late gestation and decreased circulating insulin concentration at term. Domest Anim Endocrinol. 2011;40:30–39.
- Frias AE, Morgan TK, Evans AE, Rasanen J, Oh KY, Thornburg KL, et al. Maternal high-fat diet disturbs uteroplacental hemodynamics and increases the frequency of stillbirth in a nonhuman primate model of excess nutrition. Endocrinology. 2011;152:2456–2464.
- Masuyama H, Hiramatsu Y. Treatment with constitutive androstane receptor ligand during pregnancy prevents insulin resistance in offspring from high-fat diet-induced obese pregnant mice. Am J Physiol Endocrinol Metab. 2012;303:E293–300.
- Mazzucco MB, Higa R, Capobianco E, Kurtz M, Jawerbaum A, White V. Saturated fat-rich diet increases fetal lipids and modulates LPL and leptin receptor expression in rat placentas. J Endocrinol. 2013;217:303–315.
- Jones HN, Woollett LP, Barbour N, Prasad PP, Powell TL, Jansson T. High fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/Bl6 mice. FASEB J. 2009;23:271–278.
- Kusinski LC, Jones CJ, Baker PN, Sibley CP, Glazier JD. Isolation of plasma membrane vesicles from mouse placenta at term and measurement of system A and system beta amino acid transporter activity. Placenta. 2010;31:53–59.
- Rosario FJ, Jansson N, Kanai Y, Prasad PD, Powell TL, Jansson T. Maternal protein restriction in the rat inhibits placental insulin, mTOR, and STAT3 signaling and down-regulates placental amino acid transporters. Endocrinology. 2011;152:1119–1129.
- McGowan CA, McAuliffe FM. Maternal nutrient intakes and levels of energy underreporting during early pregnancy. Eur J Clin Nutr. 2012;66:906–913.
- Gilbert PA, Khokhar S. Changing dietary habits of ethnic groups in Europe and implications for health. Nutr Rev. 2008;66:203–215.
- Nien JK, Mazaki-Tovi S, Romero R, Erez O, Kusanovic JP, Gotsch F, et al. Plasma adiponectin concentrations in non pregnant, normal pregnancy and overweight pregnant women. J Perinat Med. 2007:522–531.
- Catalano PM. Obesity, insulin resistance, and pregnancy outcome. Reproduction. 2010;140:365–371.
- Retnakaran R, Qi Y, Sermer M, Connelly PW, Hanley AJ, Zinman B. Glucose intolerance in pregnancy and future risk of pre-diabetes or diabetes. Diabetes Care. 2008;31:2026–2031.
- Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: associations with neonatal anthropometrics. Diabetes. 2009;58:453–459.
- Glazier JD, Cetin I, Perugino G, Ronzoni S, Grey AM, Mahendran D, et al. Association between the activity of the system A amino acid transporter in the microvillous plasma membrane of the human placenta and severity of fetal compromise in intrauterine growth restriction. Pediatr Res. 1997;42:514–519.
- Prendergast CH, Parker KH, Gray R, Venkatesan S, Bannister P, Castro-Soares J, et al. Glucose production by the human placenta in vivo. Placenta. 1999;20:591–598.
- Jansson T, Wennergren M, Illsley NP. Glucose transporter protein expression in human placenta throughout gestation and in intrauterine growth retardation. J Clin Endocrinol Metab. 1993;77:1554–1562.
- Ganguly A, Collis L, Devaskar SU. Placental glucose and amino acid transport in calorie-restricted wild-type and Glut3 null heterozygous mice. Endocrinology. 2012;153:3995–4007.
- Lin Y, Zhuo Y, Fang ZF, Che LQ, Wu D. Effect of maternal dietary energy types on placenta nutrient transporter gene expressions and intrauterine fetal growth in rats. Nutrition. 2012;28:1037–1043.
- Pedersen J. Weight and length at birth of infants of diabetic mothers. Acta Endocrinol. 1954:3303–42.
- Chu SY, Bachman DJ, Callaghan WM, Whitlock EP, Dietz PM, Berg CJ, et al. Association between obesity during pregnancy and increased use of health care. N Engl J Med. 2008;358:1444–1453.
- Norris SL, Zhang X, Avenell A, Gregg E, Bowman B, Schmid CH, et al. Long-term effectiveness of weight-loss interventions in adults with pre-diabetes: a review. Am J Prev Med. 2005;28:126–139.
- Sjostrom L, Peltonen M, Jacobson P, Sjostrom CD, Karason K, Wedel H, et al. Bariatric surgery and long-term cardiovascular events. JAMA. 2012;307:56–65.
- Dilworth MR, Sibley CP. Review: Transport across the placenta of mice and women. Placenta. 2013;34(Suppl):S34–39.
Source: PubMed