Stability of Motor Output in Aging Adults
Corticobulbar Motor Output in Aging Adults
Przegląd badań
Status
Warunki
Szczegółowy opis
A large number of our nation's veterans develop dysphagia due to the myriad of potential etiological sources of swallowing disorders, including stroke and head and neck cancer. The Veteran's Health Administration has recently identified dysphagia as a major clinical focus for the VA system (Sullivan & Dennis, 2006). In order to accurately assess adaptations in motor cortex, it is first necessary to have a reliable tool for measuring organizational representation in the motor cortex. Transcranial magnetic stimulation (TMS) is a desirable choice for such measurement because of the ability to identify causative relationships between an area of motor cortex stimulated and muscle response. Therefore, the specific research objectives of this proposal are:
- To demonstrate the reproducibility of TMS mapping of the submental muscle group in healthy older adults between 60 and 80 years of age
- To determine the neural representation of submental musculature in the motor cortex of healthy older adults between 60 and 80 years of age.
Twenty healthy adults, 10 men and 10 women, between the ages of 60 and 80 years will serve as research participants. TMS will be used to establish motor maps of the submental muscles. Subjects will undergo two testing sessions, on day 1 and day 14. The results from each session will be compared to assess excitability and representation within the motor cortex, and to assess stability and reliability of measurement.
Typ studiów
Zapisy (Rzeczywisty)
Kontakty i lokalizacje
Lokalizacje studiów
-
-
Florida
-
Gainesville, Florida, Stany Zjednoczone, 32608
- North Florida/South Georgia Veterans Health System
-
-
Kryteria uczestnictwa
Kryteria kwalifikacji
Wiek uprawniający do nauki
Akceptuje zdrowych ochotników
Płeć kwalifikująca się do nauki
Metoda próbkowania
Badana populacja
Opis
Inclusion Criteria:
- Between 60 and 80 years of age
Exclusion Criteria:
- History of dysphagia
- History of neurologic disease
- History of head or neck cancer
- History of stroke
- Untreated hypertension
- History of a heart condition or heart disease
- Currently pregnant
Contraindication to TMS including:
- Metallic hardware on the scalp in the area where TMS will be applied
- Cardiac pacemaker
- Implanted medication pumps or an intracardiac line
- Prior diagnosis of seizure or epilepsy in the subject (childhood history of benign febrile seizure will not be a contraindication)
- Poorly controlled migraine headaches
- Previous brain neurosurgery
- Medications that can lower seizure threshold (Appendix B)
- Unstable medical conditions
- Lowest motor thresholds above 80% on TMS
Plan studiów
Jak projektuje się badanie?
Szczegóły projektu
Kohorty i interwencje
Grupa / Kohorta |
|---|
|
1
20 healthy participants between 60 and 80 years of age.
Ten men and 10 women.
|
Co mierzy badanie?
Podstawowe miary wyniku
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
|
Mean Motor Evoked Potential Amplitude for Submental Cortical Representation
Ramy czasowe: 2 weeks
|
Cortical sites are stimulated sequentially from the SOLMT in the anterior direction.
At each site, 5 pulses of 110% of the MEP threshold obtained at the SOLMT are delivered and recorded.
If a site produces no MEP in 3/5 pulses it is considered non-submental.
This process is continued until the entire submental representation is surrounded by non-submental responsive sites.
The number of sites is used to calculate the area of submental representation.
The mean sEMG amplitudes of the submental muscles for each of these sites is then calculated for the mean MEP measure.
|
2 weeks
|
Miary wyników drugorzędnych
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
|
Motor Map Center of Gravity
Ramy czasowe: 2 weeks
|
Position on the TMS motor map with highest amplitude response to stimulation in the muscles of interest (submental muscles).
|
2 weeks
|
|
Area of Submental Representation
Ramy czasowe: 2 weeks
|
Cortical sites are stimulated sequentially from the SOLMT in the anterior direction.
At each site, 5 pulses of 110% of the MEP threshold obtained at the SOLMT are delivered and recorded.
If a site produces no MEP in 3/5 pulses it is considered non-submental.
This process is continued until the entire submental representation is surrounded by non-submental responsive sites.
The number of sites is used to calculate the area of submental representation.
|
2 weeks
|
Współpracownicy i badacze
Śledczy
- Główny śledczy: Karen Hegland, PhD, North Florida/South Georgia Veterans Health System
Daty zapisu na studia
Główne daty studiów
Rozpoczęcie studiów
Zakończenie podstawowe (Rzeczywisty)
Ukończenie studiów (Rzeczywisty)
Daty rejestracji na studia
Pierwszy przesłany
Pierwszy przesłany, który spełnia kryteria kontroli jakości
Pierwszy wysłany (Oszacować)
Aktualizacje rekordów badań
Ostatnia wysłana aktualizacja (Oszacować)
Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości
Ostatnia weryfikacja
Więcej informacji
Terminy związane z tym badaniem
Słowa kluczowe
Inne numery identyfikacyjne badania
- C6697-M
Te informacje zostały pobrane bezpośrednio ze strony internetowej clinicaltrials.gov bez żadnych zmian. Jeśli chcesz zmienić, usunąć lub zaktualizować dane swojego badania, skontaktuj się z register@clinicaltrials.gov. Gdy tylko zmiana zostanie wprowadzona na stronie clinicaltrials.gov, zostanie ona automatycznie zaktualizowana również na naszej stronie internetowej .