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Niwolumab i ipilimumab w leczeniu pacjentów z gruczolakorakiem przełyku i połączenia żołądkowo-przełykowego poddawanych zabiegom chirurgicznym

30 października 2026 zaktualizowane przez: National Cancer Institute (NCI)

Badanie fazy II/III dotyczące stosowania niwolumabu i ipilimumabu w okresie okołooperacyjnym u pacjentów z miejscowo-regionalnym gruczolakorakiem przełyku i połączenia żołądkowo-przełykowego

This phase II/III trial studies the usefulness of treatment with nivolumab and ipilimumab in addition to standard of care chemotherapy and radiation therapy in patients with esophageal and gastroesophageal junction adenocarcinoma who are undergoing surgery. Immunotherapy with antibodies, such as nivolumab and ipilimumab, may remove the brake on the body's immune system and may interfere with the ability of tumor cells to grow and spread. Chemotherapy and radiation therapy may reduce the tumor size and the amount of normal tissue that needs to be removed during surgery. A combined treatment with nivolumab and ipilimumab, chemotherapy, and radiation therapy might be more effective in patients with esophageal and gastroesophageal junction adenocarcinoma who are undergoing surgery.

Przegląd badań

Status

Zawieszony

Warunki

Interwencja / Leczenie

Szczegółowy opis

PRIMARY OBJECTIVES:

I. To assess the pathologic complete response (pathCR) rate following administration of neoadjuvant carboplatin, paclitaxel and radiation therapy versus neoadjuvant carboplatin, paclitaxel, radiation therapy and nivolumab in patients with a resected locoregionally advanced esophageal or gastroesophageal junction adenocarcinoma.

II. To assess the disease-free survival (DFS) following administration of adjuvant nivolumab and ipilimumab versus adjuvant nivolumab in patients with a resected locoregionally advanced esophageal or gastroesophageal junction adenocarcinoma who received neoadjuvant treatment with carboplatin, paclitaxel and radiation therapy with or without nivolumab.

SECONDARY OBJECTIVES:

I. To assess the overall survival (OS) following administration of adjuvant nivolumab and ipilimumab versus nivolumab in patients with a resected locoregional esophageal or gastroesophageal junctional adenocarcinoma who received neoadjuvant treatment with carboplatin, paclitaxel and radiation therapy with or without nivolumab.

II. To assess the disease free survival (DFS) following administration of neoadjuvant carboplatin, paclitaxel, and radiation therapy with or without nivolumab in patients with a locoregional esophageal or gastroesophageal junction adenocarcinoma.

III. To assess the toxicity associated with the administration of neoadjuvant nivolumab in combination with carboplatin, paclitaxel and radiation therapy in patients with a locoregional esophageal or gastroesophageal junction adenocarcinoma.

IV. To assess the toxicity associated with the administration of adjuvant nivolumab and ipilimumab versus adjuvant nivolumab in patients with a resected locoregional esophageal or gastroesophageal junction adenocarcinoma who received neoadjuvant treatment with carboplatin, paclitaxel and radiation therapy with or without nivolumab.

OUTLINE:

STEP I: Patients are randomized to 1 of 2 arms.

ARM A: Patients receive carboplatin intravenously (IV) and paclitaxel IV once weekly and undergo radiation therapy once daily (QD) (Monday-Friday) beginning on day 1 of each cycle. Cycles repeat every week for up to 5 weeks in the absence of disease progression or unacceptable toxicity. Patients undergo a computed tomography (CT) or positron emission tomography (PET) scan during screening and follow-up and undergo collection of blood samples throughout the trial.

ARM B: Patients receive carboplatin, paclitaxel, and radiation therapy as in Arm A. Patients also receive nivolumab IV over 30 minutes on days 1 and 15 of each cycle. Cycles repeat every week for up to 5 weeks in the absence of disease progression or unacceptable toxicity. Patients undergo a CT or PET scan during screening and follow-up and undergo collection of blood samples throughout the trial.

STEP II: Patients are randomized to 1 of 2 arms following standard of care surgery.

ARM C: Patients receive nivolumab IV over 30 minutes on day 1 of each cycle. Treatment repeats every 4 weeks for up to 13 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo a CT scan and collection of blood samples throughout the trial.

ARM D: Patients receive nivolumab as in Arm C and receive ipilimumab IV over 90 minutes on day 1 of cycles 1 and 4 and day 15 of cycles 2 and 5. Treatment repeats every 4 weeks for up to 13 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo a CT scan and collection of blood samples throughout the trial.

After completion of study treatment, patients are followed up every 3 months for 2 years, and then every 6 months for up to 5 years.

Typ studiów

Interwencyjne

Zapisy (Szacowany)

278

Faza

  • Faza 2
  • Faza 3

Kontakty i lokalizacje

Ta sekcja zawiera dane kontaktowe osób prowadzących badanie oraz informacje o tym, gdzie badanie jest przeprowadzane.

Lokalizacje studiów

  • Stany Zjednoczone
    • Alaska
      • Anchorage, Alaska, Stany Zjednoczone, 98508
        • Anchorage Associates in Radiation Medicine
      • Anchorage, Alaska, Stany Zjednoczone, 99508
        • Alaska Breast Care and Surgery LLC
      • Anchorage, Alaska, Stany Zjednoczone, 99508
        • Alaska Oncology and Hematology LLC
      • Anchorage, Alaska, Stany Zjednoczone, 99508
        • Alaska Women's Cancer Care
      • Anchorage, Alaska, Stany Zjednoczone, 99508
        • Anchorage Oncology Centre
      • Anchorage, Alaska, Stany Zjednoczone, 99508
        • Katmai Oncology Group
      • Anchorage, Alaska, Stany Zjednoczone, 99508
        • Providence Alaska Medical Center
    • Arizona
      • Phoenix, Arizona, Stany Zjednoczone, 85004
        • Cancer Center at Saint Joseph's
    • Arkansas
      • Fort Smith, Arkansas, Stany Zjednoczone, 72903
        • Mercy Hospital Fort Smith
      • Hot Springs, Arkansas, Stany Zjednoczone, 71913
        • CHI Saint Vincent Cancer Center Hot Springs
      • Jonesboro, Arkansas, Stany Zjednoczone, 72401
        • NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
    • California
      • Arroyo Grande, California, Stany Zjednoczone, 93420
        • PCR Oncology
      • Burbank, California, Stany Zjednoczone, 91505
        • Providence Saint Joseph Medical Center/Disney Family Cancer Center
      • Clovis, California, Stany Zjednoczone, 93611
        • Community Cancer Institute
      • Clovis, California, Stany Zjednoczone, 93611
        • University Oncology Associates
      • Los Angeles, California, Stany Zjednoczone, 90033
        • USC / Norris Comprehensive Cancer Center
      • Los Angeles, California, Stany Zjednoczone, 90033
        • Los Angeles General Medical Center
      • Palo Alto, California, Stany Zjednoczone, 94304
        • VA Palo Alto Health Care System
      • Palo Alto, California, Stany Zjednoczone, 94304
        • Stanford Cancer Institute Palo Alto
      • Sacramento, California, Stany Zjednoczone, 95817
        • University of California Davis Comprehensive Cancer Center
      • Sacramento, California, Stany Zjednoczone, 95816
        • Mercy Cancer Center - Sacramento
      • San Luis Obispo, California, Stany Zjednoczone, 93401
        • Pacific Central Coast Health Center-San Luis Obispo
      • Santa Maria, California, Stany Zjednoczone, 93444
        • Mission Hope Medical Oncology - Santa Maria
      • St. Helena, California, Stany Zjednoczone, 94574
        • Saint Helena Hospital
      • Whittier, California, Stany Zjednoczone, 90602
        • Presbyterian Intercommunity Hospital
      • Woodland, California, Stany Zjednoczone, 95695
        • Woodland Memorial Hospital
    • Colorado
      • Colorado Springs, Colorado, Stany Zjednoczone, 80907
        • Penrose-Saint Francis Healthcare
      • Colorado Springs, Colorado, Stany Zjednoczone, 80907
        • Rocky Mountain Cancer Centers-Penrose
      • Colorado Springs, Colorado, Stany Zjednoczone, 80923
        • Saint Francis Cancer Center
      • Denver, Colorado, Stany Zjednoczone, 80210
        • AdventHealth Porter
      • Lakewood, Colorado, Stany Zjednoczone, 80228
        • CommonSpirit Saint Anthony Hospital Cancer Center
      • Littleton, Colorado, Stany Zjednoczone, 80122
        • AdventHealth Littleton
      • Longmont, Colorado, Stany Zjednoczone, 80501
        • Longmont United Hospital
      • Parker, Colorado, Stany Zjednoczone, 80138
        • AdventHealth Parker
      • Pueblo, Colorado, Stany Zjednoczone, 81004
        • Saint Mary Corwin Medical Center
    • Delaware
      • Lewes, Delaware, Stany Zjednoczone, 19958
        • Beebe Medical Center
      • Millville, Delaware, Stany Zjednoczone, 19967
        • Beebe South Coastal Health Campus
      • Newark, Delaware, Stany Zjednoczone, 19713
        • Helen F Graham Cancer Center
      • Newark, Delaware, Stany Zjednoczone, 19713
        • Delaware Clinical and Laboratory Physicians PA
      • Newark, Delaware, Stany Zjednoczone, 19713
        • Medical Oncology Hematology Consultants PA
      • Newark, Delaware, Stany Zjednoczone, 19718
        • Christiana Care Health System-Christiana Hospital
      • Rehoboth Beach, Delaware, Stany Zjednoczone, 19971
        • Beebe Health Campus
      • Seaford, Delaware, Stany Zjednoczone, 19973
        • TidalHealth Nanticoke / Allen Cancer Center
    • District of Columbia
      • Washington D.C., District of Columbia, Stany Zjednoczone, 20007
        • MedStar Georgetown University Hospital
    • Florida
      • Altamonte Springs, Florida, Stany Zjednoczone, 32701
        • AdventHealth Altamonte
      • Aventura, Florida, Stany Zjednoczone, 33180
        • Mount Sinai Comprehensive Cancer Center at Aventura
      • Fort Lauderdale, Florida, Stany Zjednoczone, 33308
        • Holy Cross Hospital
      • Fort Myers, Florida, Stany Zjednoczone, 33905
        • Regional Cancer Center-Lee Memorial Health System
      • Gainesville, Florida, Stany Zjednoczone, 32610
        • UF Health Cancer Institute - Gainesville
      • Kissimmee, Florida, Stany Zjednoczone, 34744
        • AdventHealth Kissimmee
      • Miami Beach, Florida, Stany Zjednoczone, 33140
        • Mount Sinai Medical Center
      • Orlando, Florida, Stany Zjednoczone, 32803
        • AdventHealth Orlando
      • Orlando, Florida, Stany Zjednoczone, 32822
        • AdventHealth East Orlando
    • Georgia
      • Atlanta, Georgia, Stany Zjednoczone, 30308
        • Emory University Hospital Midtown
      • Atlanta, Georgia, Stany Zjednoczone, 30322
        • Emory University Hospital/Winship Cancer Institute
      • Atlanta, Georgia, Stany Zjednoczone, 30342
        • Emory Saint Joseph's Hospital
      • Atlanta, Georgia, Stany Zjednoczone, 30308
        • Emory Proton Therapy Center
      • Savannah, Georgia, Stany Zjednoczone, 31405
        • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
    • Hawaii
      • Honolulu, Hawaii, Stany Zjednoczone, 96813
        • Queen's Medical Center
      • Honolulu, Hawaii, Stany Zjednoczone, 96817
        • The Cancer Center of Hawaii-Liliha
      • Honolulu, Hawaii, Stany Zjednoczone, 96813
        • Hawaii Cancer Care Inc - Waterfront Plaza
      • Honolulu, Hawaii, Stany Zjednoczone, 96813
        • Queen's Cancer Cenrer - POB I
      • Honolulu, Hawaii, Stany Zjednoczone, 96813
        • Straub Clinic and Hospital
      • Honolulu, Hawaii, Stany Zjednoczone, 96813
        • University of Hawaii Cancer Center
      • Honolulu, Hawaii, Stany Zjednoczone, 96817
        • Hawaii Cancer Care Inc-Liliha
      • Honolulu, Hawaii, Stany Zjednoczone, 96817
        • Kuakini Medical Center
      • Honolulu, Hawaii, Stany Zjednoczone, 96817
        • Queen's Cancer Center - Kuakini
      • Honolulu, Hawaii, Stany Zjednoczone, 96826
        • Kapiolani Medical Center for Women and Children
      • Honolulu, Hawaii, Stany Zjednoczone, 96813
        • Island Urology
      • Lihue, Hawaii, Stany Zjednoczone, 96766
        • Wilcox Memorial Hospital and Kauai Medical Clinic
      • ‘Aiea, Hawaii, Stany Zjednoczone, 96701
        • Hawaii Cancer Care - Westridge
      • ‘Aiea, Hawaii, Stany Zjednoczone, 96701
        • Pali Momi Medical Center
      • ‘Aiea, Hawaii, Stany Zjednoczone, 96701
        • Queen's Cancer Center - Pearlridge
      • ‘Aiea, Hawaii, Stany Zjednoczone, 96701
        • The Cancer Center of Hawaii-Pali Momi
    • Idaho
      • Boise, Idaho, Stany Zjednoczone, 83712
        • Saint Luke's Cancer Institute - Boise
      • Fruitland, Idaho, Stany Zjednoczone, 83619
        • Saint Luke's Cancer Institute - Fruitland
      • Meridian, Idaho, Stany Zjednoczone, 83642
        • Saint Luke's Cancer Institute - Meridian
      • Nampa, Idaho, Stany Zjednoczone, 83687
        • Saint Luke's Cancer Institute - Nampa
      • Twin Falls, Idaho, Stany Zjednoczone, 83301
        • Saint Luke's Cancer Institute - Twin Falls
    • Illinois
      • Bloomington, Illinois, Stany Zjednoczone, 61704
        • Illinois CancerCare-Bloomington
      • Canton, Illinois, Stany Zjednoczone, 61520
        • Illinois CancerCare-Canton
      • Carbondale, Illinois, Stany Zjednoczone, 62902
        • Memorial Hospital of Carbondale
      • Carterville, Illinois, Stany Zjednoczone, 62918
        • SIH Cancer Institute
      • Carthage, Illinois, Stany Zjednoczone, 62321
        • Illinois CancerCare-Carthage
      • Centralia, Illinois, Stany Zjednoczone, 62801
        • Centralia Oncology Clinic
      • Chicago, Illinois, Stany Zjednoczone, 60611
        • Northwestern University
      • Chicago, Illinois, Stany Zjednoczone, 60612
        • University of Illinois
      • Decatur, Illinois, Stany Zjednoczone, 62526
        • Decatur Memorial Hospital
      • Decatur, Illinois, Stany Zjednoczone, 62526
        • Cancer Care Specialists of Illinois - Decatur
      • Dixon, Illinois, Stany Zjednoczone, 61021
        • Illinois CancerCare-Dixon
      • Effingham, Illinois, Stany Zjednoczone, 62401
        • Crossroads Cancer Center
      • Eureka, Illinois, Stany Zjednoczone, 61530
        • Illinois CancerCare-Eureka
      • Galesburg, Illinois, Stany Zjednoczone, 61401
        • Western Illinois Cancer Treatment Center
      • Galesburg, Illinois, Stany Zjednoczone, 61401
        • Illinois CancerCare-Galesburg
      • Hines, Illinois, Stany Zjednoczone, 60141
        • Edward Hines Jr VA Hospital
      • Kewanee, Illinois, Stany Zjednoczone, 61443
        • Illinois CancerCare-Kewanee Clinic
      • Lake Forest, Illinois, Stany Zjednoczone, 60045
        • Northwestern Medicine Lake Forest Hospital
      • Macomb, Illinois, Stany Zjednoczone, 61455
        • Illinois CancerCare-Macomb
      • Maywood, Illinois, Stany Zjednoczone, 60153
        • Loyola University Medical Center
      • Mount Vernon, Illinois, Stany Zjednoczone, 62864
        • SSM Health Good Samaritan
      • O'Fallon, Illinois, Stany Zjednoczone, 62269
        • Cancer Care Center of O'Fallon
      • Ottawa, Illinois, Stany Zjednoczone, 61350
        • Illinois CancerCare-Ottawa Clinic
      • Pekin, Illinois, Stany Zjednoczone, 61554
        • Illinois CancerCare-Pekin
      • Pekin, Illinois, Stany Zjednoczone, 61554
        • OSF Saint Francis Radiation Oncology at Pekin
      • Peoria, Illinois, Stany Zjednoczone, 61636
        • Methodist Medical Center of Illinois
      • Peoria, Illinois, Stany Zjednoczone, 61637
        • OSF Saint Francis Medical Center
      • Peoria, Illinois, Stany Zjednoczone, 61615
        • Illinois CancerCare-Peoria
      • Peoria, Illinois, Stany Zjednoczone, 61615
        • OSF Saint Francis Radiation Oncology at Peoria Cancer Center
      • Peru, Illinois, Stany Zjednoczone, 61354
        • Illinois CancerCare-Peru
      • Peru, Illinois, Stany Zjednoczone, 61354
        • Valley Radiation Oncology
      • Princeton, Illinois, Stany Zjednoczone, 61356
        • Illinois CancerCare-Princeton
      • Springfield, Illinois, Stany Zjednoczone, 62702
        • Southern Illinois University School of Medicine
      • Springfield, Illinois, Stany Zjednoczone, 62702
        • Springfield Clinic
      • Springfield, Illinois, Stany Zjednoczone, 62781
        • Springfield Memorial Hospital
      • Washington, Illinois, Stany Zjednoczone, 61571
        • Illinois CancerCare - Washington
    • Indiana
      • Carmel, Indiana, Stany Zjednoczone, 46032
        • IU Health North Hospital
      • Indianapolis, Indiana, Stany Zjednoczone, 46202
        • Indiana University/Melvin and Bren Simon Cancer Center
      • Richmond, Indiana, Stany Zjednoczone, 47374
        • Reid Health
    • Iowa
      • Clive, Iowa, Stany Zjednoczone, 50325
        • Mercy Cancer Center-West Lakes
      • Clive, Iowa, Stany Zjednoczone, 50325
        • UI Health Care Mission Cancer and Blood - West Des Moines Clinic
      • Creston, Iowa, Stany Zjednoczone, 50801
        • Greater Regional Medical Center
      • Des Moines, Iowa, Stany Zjednoczone, 50314
        • Mercy Medical Center - Des Moines
      • Des Moines, Iowa, Stany Zjednoczone, 50314
        • UI Health Care Mission Cancer and Blood - Laurel Clinic
      • West Des Moines, Iowa, Stany Zjednoczone, 50266
        • Mercy Medical Center-West Lakes
    • Kansas
      • Garden City, Kansas, Stany Zjednoczone, 67846
        • Central Care Cancer Center - Garden City
      • Great Bend, Kansas, Stany Zjednoczone, 67530
        • Central Care Cancer Center - Great Bend
    • Kentucky
      • Lexington, Kentucky, Stany Zjednoczone, 40504
        • Saint Joseph Radiation Oncology Resource Center
      • Lexington, Kentucky, Stany Zjednoczone, 40509
        • CommonSpirit Saint Joseph Medical Center - East Lexington
      • Lexington, Kentucky, Stany Zjednoczone, 40504
        • CommonSpirit Saint Joseph Hospital - Lexington
      • Louisville, Kentucky, Stany Zjednoczone, 40202
        • Jewish Hospital
      • Louisville, Kentucky, Stany Zjednoczone, 40245
        • UofL Health Medical Center Northeast
    • Louisiana
      • Kenner, Louisiana, Stany Zjednoczone, 70065
        • Ochsner Medical Center Kenner
      • New Orleans, Louisiana, Stany Zjednoczone, 70121
        • Ochsner Medical Center Jefferson
    • Maine
      • Bangor, Maine, Stany Zjednoczone, 04401
        • Eastern Maine Medical Center
      • Bath, Maine, Stany Zjednoczone, 04530
        • MaineHealth Coastal Cancer Treatment Center
      • Biddeford, Maine, Stany Zjednoczone, 04005
        • MaineHealth Maine Medical Center - Biddeford
      • Brewer, Maine, Stany Zjednoczone, 04412
        • Lafayette Family Cancer Center-EMMC
      • Portland, Maine, Stany Zjednoczone, 04102
        • MaineHealth Maine Medical Center - Portland
      • Sanford, Maine, Stany Zjednoczone, 04073
        • MaineHealth Cancer Care Center of York County
      • Sanford, Maine, Stany Zjednoczone, 04073
        • MaineHealth Cancer Care and IV Therapy - Sanford
      • Scarborough, Maine, Stany Zjednoczone, 04074
        • MaineHealth Maine Medical Center- Scarborough
      • South Portland, Maine, Stany Zjednoczone, 04106
        • MaineHealth Cancer Care and IV Therapy - South Portland
    • Massachusetts
      • Boston, Massachusetts, Stany Zjednoczone, 02111
        • Tufts Medical Center
      • Boston, Massachusetts, Stany Zjednoczone, 02118
        • Boston Medical Center
      • Lowell, Massachusetts, Stany Zjednoczone, 01854
        • Lowell General Hospital
    • Michigan
      • Ann Arbor, Michigan, Stany Zjednoczone, 48106
        • Trinity Health Saint Joseph Mercy Hospital Ann Arbor
      • Brighton, Michigan, Stany Zjednoczone, 48114
        • Trinity Health IHA Medical Group Hematology Oncology - Brighton
      • Brighton, Michigan, Stany Zjednoczone, 48114
        • Trinity Health Medical Center - Brighton
      • Canton, Michigan, Stany Zjednoczone, 48188
        • Trinity Health IHA Medical Group Hematology Oncology - Canton
      • Canton, Michigan, Stany Zjednoczone, 48188
        • Trinity Health Medical Center - Canton
      • Caro, Michigan, Stany Zjednoczone, 48723
        • Caro Cancer Center
      • Chelsea, Michigan, Stany Zjednoczone, 48118
        • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
      • Chelsea, Michigan, Stany Zjednoczone, 48118
        • Chelsea Hospital
      • Detroit, Michigan, Stany Zjednoczone, 48236
        • Henry Ford Health Saint John Hospital
      • Flint, Michigan, Stany Zjednoczone, 48503
        • Hurley Medical Center
      • Flint, Michigan, Stany Zjednoczone, 48503
        • Genesys Hurley Cancer Institute
      • Grosse Pointe Woods, Michigan, Stany Zjednoczone, 48236
        • Henry Ford Saint John Hospital - Van Elslander
      • Lansing, Michigan, Stany Zjednoczone, 48912
        • University of Michigan Health - Sparrow Lansing
      • Livonia, Michigan, Stany Zjednoczone, 48154
        • Trinity Health Saint Mary Mercy Livonia Hospital
      • Macomb, Michigan, Stany Zjednoczone, 48044
        • Henry Ford Saint John Hospital - Macomb Medical
      • Marlette, Michigan, Stany Zjednoczone, 48453
        • Saint Mary's Oncology/Hematology Associates of Marlette
      • Novi, Michigan, Stany Zjednoczone, 48374
        • Henry Ford Health Providence Novi Hospital
      • Pontiac, Michigan, Stany Zjednoczone, 48341
        • Trinity Health Saint Joseph Mercy Oakland Hospital
      • Pontiac, Michigan, Stany Zjednoczone, 48341
        • Michigan Healthcare Professionals Pontiac
      • Saginaw, Michigan, Stany Zjednoczone, 48604
        • Oncology Hematology Associates of Saginaw Valley PC
      • Saginaw, Michigan, Stany Zjednoczone, 48601
        • MyMichigan Medical Center Saginaw
      • Southfield, Michigan, Stany Zjednoczone, 48075
        • Henry Ford Health Providence Southfield Hospital
      • Tawas City, Michigan, Stany Zjednoczone, 48764
        • MyMichigan Medical Center Tawas
      • Warren, Michigan, Stany Zjednoczone, 48093
        • Henry Ford Health Warren Hospital
      • West Branch, Michigan, Stany Zjednoczone, 48661
        • Saint Mary's Oncology/Hematology Associates of West Branch
      • Ypsilanti, Michigan, Stany Zjednoczone, 48197
        • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
    • Minnesota
      • Bemidji, Minnesota, Stany Zjednoczone, 56601
        • Sanford Joe Lueken Cancer Center
      • Brainerd, Minnesota, Stany Zjednoczone, 56401
        • Essentia Health Saint Joseph's Medical Center
      • Burnsville, Minnesota, Stany Zjednoczone, 55337
        • Fairview Ridges Hospital
      • Burnsville, Minnesota, Stany Zjednoczone, 55337
        • Minnesota Oncology - Burnsville
      • Coon Rapids, Minnesota, Stany Zjednoczone, 55433
        • Mercy Hospital
      • Deer River, Minnesota, Stany Zjednoczone, 56636
        • Essentia Health - Deer River Clinic
      • Detroit Lakes, Minnesota, Stany Zjednoczone, 56501
        • Essentia Health Saint Mary's - Detroit Lakes Clinic
      • Duluth, Minnesota, Stany Zjednoczone, 55805
        • Essentia Health Cancer Center
      • Duluth, Minnesota, Stany Zjednoczone, 55805
        • Essentia Health Saint Mary's Medical Center
      • Duluth, Minnesota, Stany Zjednoczone, 55805
        • Miller-Dwan Hospital
      • Edina, Minnesota, Stany Zjednoczone, 55435
        • Fairview Southdale Hospital
      • Edina, Minnesota, Stany Zjednoczone, 55435
        • Minnesota Oncology - Edina
      • Fergus Falls, Minnesota, Stany Zjednoczone, 56537
        • Lake Region Healthcare Corporation-Cancer Care
      • Fosston, Minnesota, Stany Zjednoczone, 56542
        • Essentia Health - Fosston
      • Fridley, Minnesota, Stany Zjednoczone, 55432
        • Unity Hospital
      • Hibbing, Minnesota, Stany Zjednoczone, 55746
        • Essentia Health Hibbing Clinic
      • Maple Grove, Minnesota, Stany Zjednoczone, 55369
        • Fairview Clinics and Surgery Center Maple Grove
      • Maplewood, Minnesota, Stany Zjednoczone, 55109
        • Saint John's Hospital - Healtheast
      • Maplewood, Minnesota, Stany Zjednoczone, 55109
        • Minnesota Oncology Hematology PA-Maplewood
      • Minneapolis, Minnesota, Stany Zjednoczone, 55415
        • Hennepin County Medical Center
      • Minneapolis, Minnesota, Stany Zjednoczone, 55407
        • Abbott-Northwestern Hospital
      • Minneapolis, Minnesota, Stany Zjednoczone, 55454
        • Health Partners Inc
      • Monticello, Minnesota, Stany Zjednoczone, 55362
        • Monticello Cancer Center
      • Park Rapids, Minnesota, Stany Zjednoczone, 56470
        • Essentia Health - Park Rapids
      • Robbinsdale, Minnesota, Stany Zjednoczone, 55422
        • North Memorial Medical Health Center
      • Rochester, Minnesota, Stany Zjednoczone, 55905
        • Mayo Clinic in Rochester
      • Saint Louis Park, Minnesota, Stany Zjednoczone, 55416
        • Park Nicollet Clinic - Saint Louis Park
      • Saint Paul, Minnesota, Stany Zjednoczone, 55101
        • Regions Hospital
      • Saint Paul, Minnesota, Stany Zjednoczone, 55102
        • United Hospital
      • Sandstone, Minnesota, Stany Zjednoczone, 55072
        • Essentia Health Sandstone
      • Shakopee, Minnesota, Stany Zjednoczone, 55379
        • Saint Francis Regional Medical Center
      • Stillwater, Minnesota, Stany Zjednoczone, 55082
        • Lakeview Hospital
      • Virginia, Minnesota, Stany Zjednoczone, 55792
        • Essentia Health Virginia Clinic
      • Waconia, Minnesota, Stany Zjednoczone, 55387
        • Ridgeview Medical Center
      • Willmar, Minnesota, Stany Zjednoczone, 56201
        • Rice Memorial Hospital
      • Woodbury, Minnesota, Stany Zjednoczone, 55125
        • Minnesota Oncology Hematology PA-Woodbury
    • Mississippi
      • Columbus, Mississippi, Stany Zjednoczone, 39705
        • Baptist Memorial Hospital and Cancer Center-Golden Triangle
      • Grenada, Mississippi, Stany Zjednoczone, 38901
        • Baptist Cancer Center-Grenada
      • New Albany, Mississippi, Stany Zjednoczone, 38652
        • Baptist Memorial Hospital and Cancer Center-Union County
      • Oxford, Mississippi, Stany Zjednoczone, 38655
        • Baptist Memorial Hospital and Cancer Center-Oxford
      • Southhaven, Mississippi, Stany Zjednoczone, 38671
        • Baptist Memorial Hospital and Cancer Center-Desoto
    • Missouri
      • Ballwin, Missouri, Stany Zjednoczone, 63011
        • Mercy Oncology and Hematology - Clayton-Clarkson
      • Bolivar, Missouri, Stany Zjednoczone, 65613
        • Central Care Cancer Center - Bolivar
      • Cape Girardeau, Missouri, Stany Zjednoczone, 63703
        • Saint Francis Medical Center
      • Cape Girardeau, Missouri, Stany Zjednoczone, 63703
        • Mercy Cancer Center - Cape Girardeau
      • City of Saint Peters, Missouri, Stany Zjednoczone, 63376
        • Siteman Cancer Center at Saint Peters Hospital
      • Creve Coeur, Missouri, Stany Zjednoczone, 63141
        • Siteman Cancer Center at West County Hospital
      • Farmington, Missouri, Stany Zjednoczone, 63640
        • Parkland Health Center - Farmington
      • Jefferson City, Missouri, Stany Zjednoczone, 65109
        • MU Health Care Goldschmidt Cancer Center
      • Joplin, Missouri, Stany Zjednoczone, 64804
        • Freeman Health System
      • Joplin, Missouri, Stany Zjednoczone, 64804
        • Mercy Hospital Joplin
      • Rolla, Missouri, Stany Zjednoczone, 65401
        • Mercy Clinic-Rolla-Cancer and Hematology
      • Rolla, Missouri, Stany Zjednoczone, 65401
        • Phelps Health Delbert Day Cancer Institute
      • Saint Joseph, Missouri, Stany Zjednoczone, 64506
        • Heartland Regional Medical Center
      • Sainte Genevieve, Missouri, Stany Zjednoczone, 63670
        • Sainte Genevieve County Memorial Hospital
      • Springfield, Missouri, Stany Zjednoczone, 65807
        • CoxHealth South Hospital
      • Springfield, Missouri, Stany Zjednoczone, 65804
        • Mercy Hospital Springfield
      • St Louis, Missouri, Stany Zjednoczone, 63110
        • Washington University School of Medicine
      • St Louis, Missouri, Stany Zjednoczone, 63129
        • Siteman Cancer Center-South County
      • St Louis, Missouri, Stany Zjednoczone, 63136
        • Siteman Cancer Center at Christian Hospital
      • St Louis, Missouri, Stany Zjednoczone, 63131
        • Missouri Baptist Medical Center
      • St Louis, Missouri, Stany Zjednoczone, 63141
        • Mercy Hospital Saint Louis
      • St Louis, Missouri, Stany Zjednoczone, 63128
        • Mercy Hospital South
      • Sullivan, Missouri, Stany Zjednoczone, 63080
        • Missouri Baptist Sullivan Hospital
    • Montana
      • Missoula, Montana, Stany Zjednoczone, 59802
        • Saint Patrick Hospital - Community Hospital
    • Nebraska
      • Bellevue, Nebraska, Stany Zjednoczone, 68123
        • Nebraska Medicine-Bellevue
      • Grand Island, Nebraska, Stany Zjednoczone, 68803
        • Nebraska Cancer Specialists/Oncology Hematology West PC
      • Kearney, Nebraska, Stany Zjednoczone, 68847
        • CHI Health Good Samaritan
      • Omaha, Nebraska, Stany Zjednoczone, 68198
        • University of Nebraska Medical Center
      • Omaha, Nebraska, Stany Zjednoczone, 68124
        • Alegent Health Bergan Mercy Medical Center
      • Omaha, Nebraska, Stany Zjednoczone, 68118
        • Nebraska Medicine-Village Pointe
      • Omaha, Nebraska, Stany Zjednoczone, 68122
        • Alegent Health Immanuel Medical Center
      • Omaha, Nebraska, Stany Zjednoczone, 68130
        • Alegent Health Lakeside Hospital
    • Nevada
      • Henderson, Nevada, Stany Zjednoczone, 89052
        • Comprehensive Cancer Centers of Nevada - Henderson
      • Henderson, Nevada, Stany Zjednoczone, 89074
        • Oncology Las Vegas - Henderson
      • Las Vegas, Nevada, Stany Zjednoczone, 89102
        • OptumCare Cancer Care at Charleston
      • Las Vegas, Nevada, Stany Zjednoczone, 89106
        • Radiation Oncology Centers of Nevada Central
      • Las Vegas, Nevada, Stany Zjednoczone, 89119
        • Radiation Oncology Centers of Nevada Southeast
      • Las Vegas, Nevada, Stany Zjednoczone, 89128
        • Comprehensive Cancer Centers of Nevada - Northwest
      • Las Vegas, Nevada, Stany Zjednoczone, 89128
        • OptumCare Cancer Care at MountainView
      • Las Vegas, Nevada, Stany Zjednoczone, 89135
        • Alliance for Childhood Diseases/Cure 4 the Kids Foundation
      • Las Vegas, Nevada, Stany Zjednoczone, 89144
        • Comprehensive Cancer Centers of Nevada - Town Center
      • Las Vegas, Nevada, Stany Zjednoczone, 89144
        • Comprehensive Cancer Centers of Nevada-Summerlin
      • Las Vegas, Nevada, Stany Zjednoczone, 89148
        • Comprehensive Cancer Centers of Nevada
      • Las Vegas, Nevada, Stany Zjednoczone, 89169
        • Comprehensive Cancer Centers of Nevada - Central Valley
      • Las Vegas, Nevada, Stany Zjednoczone, 89183
        • OptumCare Cancer Care at Fort Apache
      • Reno, Nevada, Stany Zjednoczone, 89502
        • Renown Regional Medical Center
      • Reno, Nevada, Stany Zjednoczone, 89503
        • Saint Mary's Regional Medical Center
      • Reno, Nevada, Stany Zjednoczone, 89509
        • Radiation Oncology Associates
    • New Hampshire
      • Lebanon, New Hampshire, Stany Zjednoczone, 03756
        • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
    • New Jersey
      • Brick, New Jersey, Stany Zjednoczone, 08724
        • Ocean University Medical Center
      • Long Branch, New Jersey, Stany Zjednoczone, 07740
        • Monmouth Medical Center
      • Manahawkin, New Jersey, Stany Zjednoczone, 08050
        • Southern Ocean County Medical Center
      • Neptune City, New Jersey, Stany Zjednoczone, 07753
        • Jersey Shore Medical Center
      • New Brunswick, New Jersey, Stany Zjednoczone, 08903
        • Rutgers Cancer Institute of New Jersey
      • Red Bank, New Jersey, Stany Zjednoczone, 07701
        • Riverview Medical Center/Booker Cancer Center
      • Toms River, New Jersey, Stany Zjednoczone, 08755
        • Community Medical Center
    • New Mexico
      • Albuquerque, New Mexico, Stany Zjednoczone, 87102
        • Lovelace Medical Center-Saint Joseph Square
      • Albuquerque, New Mexico, Stany Zjednoczone, 87109
        • New Mexico Oncology Hematology Consultants
      • Albuquerque, New Mexico, Stany Zjednoczone, 87106
        • University of New Mexico Cancer Center
      • Albuquerque, New Mexico, Stany Zjednoczone, 87110
        • Presbyterian Kaseman Hospital
      • Rio Rancho, New Mexico, Stany Zjednoczone, 87124
        • Presbyterian Rust Medical Center/Jorgensen Cancer Center
    • New York
      • Canandaigua, New York, Stany Zjednoczone, 14424
        • Sands Cancer Center
      • Dansville, New York, Stany Zjednoczone, 14437
        • Noyes Memorial Hospital/Myers Cancer Center
      • Glens Falls, New York, Stany Zjednoczone, 12801
        • Glens Falls Hospital
      • Lake Success, New York, Stany Zjednoczone, 11042
        • Northwell Health/Center for Advanced Medicine
      • Middletown, New York, Stany Zjednoczone, 10940
        • Garnet Health Medical Center
      • New York, New York, Stany Zjednoczone, 10065
        • NYP/Weill Cornell Medical Center
      • New York, New York, Stany Zjednoczone, 10016
        • Laura and Isaac Perlmutter Cancer Center at NYU Langone
      • Rochester, New York, Stany Zjednoczone, 14642
        • University of Rochester
      • Syracuse, New York, Stany Zjednoczone, 13210
        • State University of New York Upstate Medical University
      • The Bronx, New York, Stany Zjednoczone, 10461
        • Montefiore Medical Center-Einstein Campus
      • The Bronx, New York, Stany Zjednoczone, 10467
        • Montefiore Medical Center - Moses Campus
      • The Bronx, New York, Stany Zjednoczone, 10461
        • Montefiore Medical Center-Weiler Hospital
    • North Carolina
      • Charlotte, North Carolina, Stany Zjednoczone, 28204
        • Novant Health Presbyterian Medical Center
      • Huntersville, North Carolina, Stany Zjednoczone, 28078
        • Novant Health Cancer Institute - Huntersville
      • Huntersville, North Carolina, Stany Zjednoczone, 28078
        • Novant Health Presbyterian Medical Center Huntersville
      • Kernersville, North Carolina, Stany Zjednoczone, 27284
        • Novant Health Cancer Institute - Kernersville
      • Matthews, North Carolina, Stany Zjednoczone, 28105
        • Matthews Radiation Oncology Center
      • Matthews, North Carolina, Stany Zjednoczone, 28105
        • Novant Health Cancer Institute - Matthews
      • Mooresville, North Carolina, Stany Zjednoczone, 28117
        • Novant Health Cancer Institute - Mooresville
      • Mount Airy, North Carolina, Stany Zjednoczone, 27030
        • Novant Health Cancer Institute - Mount Airy
      • North Wilkesboro, North Carolina, Stany Zjednoczone, 28659
        • Novant Health Cancer Institute - Wilkesboro
      • Salisbury, North Carolina, Stany Zjednoczone, 28144
        • Rowan Regional Medical Center
      • Statesville, North Carolina, Stany Zjednoczone, 28625
        • Novant Health Cancer Institute - Statesville
      • Thomasville, North Carolina, Stany Zjednoczone, 27360
        • Novant Health Cancer Institute - Thomasville
      • Winston-Salem, North Carolina, Stany Zjednoczone, 27103
        • Novant Health Forsyth Medical Center
    • North Dakota
      • Bismarck, North Dakota, Stany Zjednoczone, 58501
        • Sanford Bismarck Medical Center
      • Fargo, North Dakota, Stany Zjednoczone, 58122
        • Sanford Roger Maris Cancer Center
      • Fargo, North Dakota, Stany Zjednoczone, 58103
        • Essentia Health Cancer Center-South University Clinic
      • Fargo, North Dakota, Stany Zjednoczone, 58122
        • Sanford Broadway Medical Center
      • Jamestown, North Dakota, Stany Zjednoczone, 58401
        • Essentia Health - Jamestown Clinic
    • Ohio
      • Beavercreek, Ohio, Stany Zjednoczone, 45431
        • Indu and Raj Soin Medical Center
      • Boardman, Ohio, Stany Zjednoczone, 44512
        • Saint Elizabeth Boardman Hospital
      • Centerville, Ohio, Stany Zjednoczone, 45459
        • Miami Valley Hospital South
      • Centerville, Ohio, Stany Zjednoczone, 45459
        • Dayton Physicians LLC-Miami Valley South
      • Cincinnati, Ohio, Stany Zjednoczone, 45219
        • University of Cincinnati Cancer Center-UC Medical Center
      • Cincinnati, Ohio, Stany Zjednoczone, 45220
        • Good Samaritan Hospital - Cincinnati
      • Cincinnati, Ohio, Stany Zjednoczone, 45242
        • Bethesda North Hospital
      • Cincinnati, Ohio, Stany Zjednoczone, 45236
        • Oncology Hematology Care Inc-Kenwood
      • Cleveland, Ohio, Stany Zjednoczone, 44109
        • MetroHealth Medical Center
      • Cleveland, Ohio, Stany Zjednoczone, 44195
        • Cleveland Clinic Foundation
      • Cleveland, Ohio, Stany Zjednoczone, 44111
        • Cleveland Clinic Cancer Center/Fairview Hospital
      • Columbus, Ohio, Stany Zjednoczone, 43210
        • Ohio State University Comprehensive Cancer Center
      • Dayton, Ohio, Stany Zjednoczone, 45409
        • Miami Valley Hospital
      • Dayton, Ohio, Stany Zjednoczone, 45415
        • Miami Valley Hospital North
      • Dayton, Ohio, Stany Zjednoczone, 45415
        • Dayton Physician LLC - Englewood
      • Findlay, Ohio, Stany Zjednoczone, 45840
        • Blanchard Valley Hospital
      • Findlay, Ohio, Stany Zjednoczone, 45840
        • Armes Family Cancer Center
      • Findlay, Ohio, Stany Zjednoczone, 45840
        • Orion Cancer Care
      • Franklin, Ohio, Stany Zjednoczone, 45005-1066
        • Atrium Medical Center-Middletown Regional Hospital
      • Franklin, Ohio, Stany Zjednoczone, 45005
        • Dayton Physicians LLC-Atrium
      • Greenville, Ohio, Stany Zjednoczone, 45331
        • Wayne Hospital
      • Greenville, Ohio, Stany Zjednoczone, 45331
        • Dayton Physicians LLC-Wayne
      • Independence, Ohio, Stany Zjednoczone, 44131
        • Cleveland Clinic Cancer Center Independence
      • Kettering, Ohio, Stany Zjednoczone, 45429
        • Kettering Medical Center
      • Kettering, Ohio, Stany Zjednoczone, 45409
        • Greater Dayton Cancer Center
      • Mansfield, Ohio, Stany Zjednoczone, 44906
        • Cleveland Clinic Cancer Center Mansfield
      • Mayfield Heights, Ohio, Stany Zjednoczone, 44124
        • Hillcrest Hospital Cancer Center
      • Sandusky, Ohio, Stany Zjednoczone, 44870
        • North Coast Cancer Care
      • Springfield, Ohio, Stany Zjednoczone, 45504
        • Springfield Regional Cancer Center
      • Springfield, Ohio, Stany Zjednoczone, 45504
        • Springfield Regional Medical Center
      • Strongsville, Ohio, Stany Zjednoczone, 44136
        • Cleveland Clinic Cancer Center Strongsville
      • Sylvania, Ohio, Stany Zjednoczone, 43560
        • ProMedica Flower Hospital
      • Toledo, Ohio, Stany Zjednoczone, 43606
        • ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
      • Troy, Ohio, Stany Zjednoczone, 45373
        • Upper Valley Medical Center
      • Troy, Ohio, Stany Zjednoczone, 45373
        • Dayton Physicians LLC - Troy
      • Warren, Ohio, Stany Zjednoczone, 44484
        • Saint Joseph Warren Hospital
      • Warrensville Heights, Ohio, Stany Zjednoczone, 44122
        • South Pointe Hospital
      • West Chester, Ohio, Stany Zjednoczone, 45069
        • University of Cincinnati Cancer Center-West Chester
      • Wooster, Ohio, Stany Zjednoczone, 44691
        • Cleveland Clinic Wooster Family Health and Surgery Center
      • Youngstown, Ohio, Stany Zjednoczone, 44501
        • Saint Elizabeth Youngstown Hospital
    • Oklahoma
      • Oklahoma City, Oklahoma, Stany Zjednoczone, 73120
        • Mercy Hospital Oklahoma City
    • Oregon
      • Bend, Oregon, Stany Zjednoczone, 97701
        • Saint Charles Health System
      • Clackamas, Oregon, Stany Zjednoczone, 97015
        • Clackamas Radiation Oncology Center
      • Clackamas, Oregon, Stany Zjednoczone, 97015
        • Providence Cancer Institute Clackamas Clinic
      • Coos Bay, Oregon, Stany Zjednoczone, 97420
        • Bay Area Hospital
      • Newberg, Oregon, Stany Zjednoczone, 97132
        • Providence Newberg Medical Center
      • Portland, Oregon, Stany Zjednoczone, 97213
        • Providence Portland Medical Center
      • Portland, Oregon, Stany Zjednoczone, 97225
        • Providence Saint Vincent Medical Center
    • Pennsylvania
      • Allentown, Pennsylvania, Stany Zjednoczone, 18103
        • Lehigh Valley Hospital-Cedar Crest
      • Allentown, Pennsylvania, Stany Zjednoczone, 18104
        • Saint Luke's Cancer Center - Allentown
      • Altoona, Pennsylvania, Stany Zjednoczone, 16601
        • UPMC Altoona
      • Beaver, Pennsylvania, Stany Zjednoczone, 15009
        • UPMC-Heritage Valley Health System Beaver
      • Bethlehem, Pennsylvania, Stany Zjednoczone, 18017
        • Lehigh Valley Hospital - Muhlenberg
      • Bethlehem, Pennsylvania, Stany Zjednoczone, 18015
        • Saint Luke's University Hospital-Bethlehem Campus
      • Butler, Pennsylvania, Stany Zjednoczone, 16001
        • UPMC Hillman Cancer Center at Butler Health System
      • Camp Hill, Pennsylvania, Stany Zjednoczone, 17011
        • UPMC Camp Hill
      • Carlisle, Pennsylvania, Stany Zjednoczone, 17015
        • Carlisle Regional Cancer Center
      • Chadds Ford, Pennsylvania, Stany Zjednoczone, 19317
        • Christiana Care Health System-Concord Health Center
      • Danville, Pennsylvania, Stany Zjednoczone, 17822
        • Geisinger Medical Center
      • East Stroudsburg, Pennsylvania, Stany Zjednoczone, 18301
        • Pocono Medical Center
      • Easton, Pennsylvania, Stany Zjednoczone, 18045
        • Saint Luke's Hospital-Anderson Campus
      • Erie, Pennsylvania, Stany Zjednoczone, 16505
        • UPMC Hillman Cancer Center Erie
      • Farrell, Pennsylvania, Stany Zjednoczone, 16121
        • UPMC Cancer Center at UPMC Horizon
      • Greensburg, Pennsylvania, Stany Zjednoczone, 15601
        • UPMC Cancer Centers - Arnold Palmer Pavilion
      • Harrisburg, Pennsylvania, Stany Zjednoczone, 17109
        • UPMC Pinnacle Cancer Center/Community Osteopathic Campus
      • Hershey, Pennsylvania, Stany Zjednoczone, 17033-0850
        • Penn State Milton S Hershey Medical Center
      • Indiana, Pennsylvania, Stany Zjednoczone, 15701
        • IRMC Cancer Center
      • Jefferson Hills, Pennsylvania, Stany Zjednoczone, 15025
        • Jefferson Hospital
      • Johnstown, Pennsylvania, Stany Zjednoczone, 15901
        • UPMC-Johnstown/John P. Murtha Regional Cancer Center
      • Lewisburg, Pennsylvania, Stany Zjednoczone, 17837
        • Geisinger Medical Oncology-Lewisburg
      • McKeesport, Pennsylvania, Stany Zjednoczone, 15132
        • UPMC Cancer Center at UPMC McKeesport
      • Monroeville, Pennsylvania, Stany Zjednoczone, 15146
        • Forbes Hospital
      • Monroeville, Pennsylvania, Stany Zjednoczone, 15146
        • UPMC Hillman Cancer Center - Monroeville
      • Monroeville, Pennsylvania, Stany Zjednoczone, 15146
        • UPMC Cancer Center - Monroeville
      • Moon Township, Pennsylvania, Stany Zjednoczone, 15108
        • UPMC Hillman Cancer Center in Coraopolis
      • Mount Pleasant, Pennsylvania, Stany Zjednoczone, 15666
        • UPMC Hillman Cancer Center - Part of Frick Hospital
      • N. Huntingdon, Pennsylvania, Stany Zjednoczone, 15642
        • Arnold Palmer Cancer Center Medical Oncology Norwin
      • Natrona Heights, Pennsylvania, Stany Zjednoczone, 15065
        • Allegheny Valley Hospital
      • New Castle, Pennsylvania, Stany Zjednoczone, 16105
        • UPMC Hillman Cancer Center - New Castle
      • Philadelphia, Pennsylvania, Stany Zjednoczone, 19104
        • University of Pennsylvania/Abramson Cancer Center
      • Pittsburgh, Pennsylvania, Stany Zjednoczone, 15212
        • Allegheny General Hospital
      • Pittsburgh, Pennsylvania, Stany Zjednoczone, 15224
        • West Penn Hospital
      • Pittsburgh, Pennsylvania, Stany Zjednoczone, 15232
        • UPMC Hillman Cancer Center
      • Pittsburgh, Pennsylvania, Stany Zjednoczone, 15213
        • UPMC-Magee Womens Hospital
      • Pittsburgh, Pennsylvania, Stany Zjednoczone, 15232
        • UPMC-Shadyside Hospital
      • Pittsburgh, Pennsylvania, Stany Zjednoczone, 15215
        • UPMC-Saint Margaret
      • Pittsburgh, Pennsylvania, Stany Zjednoczone, 15237
        • UPMC-Passavant Hospital
      • Pittsburgh, Pennsylvania, Stany Zjednoczone, 15243
        • UPMC-Saint Clair Hospital Cancer Center
      • Pottstown, Pennsylvania, Stany Zjednoczone, 19464
        • Pottstown Hospital
      • Seneca, Pennsylvania, Stany Zjednoczone, 16346
        • UPMC Cancer Center at UPMC Northwest
      • Uniontown, Pennsylvania, Stany Zjednoczone, 15401
        • UPMC Uniontown Hospital Radiation Oncology
      • Uniontown, Pennsylvania, Stany Zjednoczone, 15401
        • UPMC Cancer Center-Uniontown
      • Washington, Pennsylvania, Stany Zjednoczone, 15301
        • UPMC Washington Hospital Radiation Oncology
      • Washington, Pennsylvania, Stany Zjednoczone, 15301
        • UPMC Cancer Center-Washington
      • West Mifflin, Pennsylvania, Stany Zjednoczone, 15122
        • UPMC West Mifflin-Cancer Center Jefferson
      • West Reading, Pennsylvania, Stany Zjednoczone, 19611
        • Reading Hospital
      • Wexford, Pennsylvania, Stany Zjednoczone, 15090
        • Wexford Health and Wellness Pavilion
      • York, Pennsylvania, Stany Zjednoczone, 17408
        • UPMC Memorial
    • Rhode Island
      • East Greenwich, Rhode Island, Stany Zjednoczone, 02818
        • Rhode Island Hospital at East Greenwich
      • Newport, Rhode Island, Stany Zjednoczone, 02840
        • Newport Hospital
      • Providence, Rhode Island, Stany Zjednoczone, 02903
        • Rhode Island Hospital
    • South Carolina
      • Charleston, South Carolina, Stany Zjednoczone, 29425
        • Medical University of South Carolina
      • Greenville, South Carolina, Stany Zjednoczone, 29607
        • Saint Francis Cancer Center
      • Greenville, South Carolina, Stany Zjednoczone, 29601
        • Saint Francis Hospital
    • South Dakota
      • Sioux Falls, South Dakota, Stany Zjednoczone, 57105
        • Avera Cancer Institute
      • Sioux Falls, South Dakota, Stany Zjednoczone, 57117-5134
        • Sanford USD Medical Center - Sioux Falls
      • Sioux Falls, South Dakota, Stany Zjednoczone, 57104
        • Sanford Cancer Center Oncology Clinic
    • Tennessee
      • Collierville, Tennessee, Stany Zjednoczone, 38017
        • Baptist Memorial Hospital and Cancer Center-Collierville
      • Memphis, Tennessee, Stany Zjednoczone, 38120
        • Baptist Memorial Hospital and Cancer Center-Memphis
      • Nashville, Tennessee, Stany Zjednoczone, 37232
        • Vanderbilt University/Ingram Cancer Center
    • Texas
      • Bryan, Texas, Stany Zjednoczone, 77802
        • Saint Joseph Regional Cancer Center
      • Dallas, Texas, Stany Zjednoczone, 75235
        • Parkland Memorial Hospital
      • Dallas, Texas, Stany Zjednoczone, 75390
        • UT Southwestern/Simmons Cancer Center-Dallas
      • Fort Worth, Texas, Stany Zjednoczone, 76104
        • UT Southwestern/Simmons Cancer Center-Fort Worth
      • Richardson, Texas, Stany Zjednoczone, 75080
        • UT Southwestern Clinical Center at Richardson/Plano
    • Utah
      • Salt Lake City, Utah, Stany Zjednoczone, 84112
        • Huntsman Cancer Institute/University of Utah
      • Salt Lake City, Utah, Stany Zjednoczone, 84106
        • University of Utah Sugarhouse Health Center
    • Vermont
      • Berlin Corners, Vermont, Stany Zjednoczone, 05602
        • Central Vermont Medical Center/National Life Cancer Treatment
      • Burlington, Vermont, Stany Zjednoczone, 05401
        • University of Vermont Medical Center
      • Burlington, Vermont, Stany Zjednoczone, 05405
        • University of Vermont and State Agricultural College
      • Saint Johnsbury, Vermont, Stany Zjednoczone, 05819
        • Dartmouth Cancer Center - North
    • Virginia
      • Charlottesville, Virginia, Stany Zjednoczone, 22908
        • University of Virginia Cancer Center
      • Richmond, Virginia, Stany Zjednoczone, 23229
        • Virginia Cancer Institute
      • Richmond, Virginia, Stany Zjednoczone, 23298
        • VCU Massey Comprehensive Cancer Center
      • South Hill, Virginia, Stany Zjednoczone, 23970
        • VCU Community Memorial Health Center
    • Washington
      • Aberdeen, Washington, Stany Zjednoczone, 98520
        • Providence Regional Cancer System-Aberdeen
      • Bellevue, Washington, Stany Zjednoczone, 98004
        • Overlake Medical Center
      • Bellingham, Washington, Stany Zjednoczone, 98225
        • PeaceHealth Saint Joseph Medical Center
      • Burien, Washington, Stany Zjednoczone, 98166
        • Saint Anne Hospital
      • Centralia, Washington, Stany Zjednoczone, 98531
        • Providence Regional Cancer System-Centralia
      • Edmonds, Washington, Stany Zjednoczone, 98026
        • Swedish Cancer Institute-Edmonds
      • Everett, Washington, Stany Zjednoczone, 98201
        • Providence Regional Cancer Partnership
      • Issaquah, Washington, Stany Zjednoczone, 98029
        • Swedish Cancer Institute-Issaquah
      • Lacey, Washington, Stany Zjednoczone, 98503
        • Providence Regional Cancer System-Lacey
      • Longview, Washington, Stany Zjednoczone, 98632
        • PeaceHealth Saint John Medical Center
      • Renton, Washington, Stany Zjednoczone, 98055
        • Valley Medical Center
      • Seattle, Washington, Stany Zjednoczone, 98107
        • Swedish Medical Center-Ballard Campus
      • Seattle, Washington, Stany Zjednoczone, 98122
        • Swedish Medical Center-First Hill
      • Sedro-Woolley, Washington, Stany Zjednoczone, 98284
        • PeaceHealth United General Medical Center
      • Silverdale, Washington, Stany Zjednoczone, 98383
        • Saint Joseph Medical Center Hematology and Oncology - Silverdale
      • Tacoma, Washington, Stany Zjednoczone, 98405
        • Northwest Medical Specialties PLLC
      • Vancouver, Washington, Stany Zjednoczone, 98664
        • PeaceHealth Southwest Medical Center
      • Walla Walla, Washington, Stany Zjednoczone, 99362
        • Providence Saint Mary Regional Cancer Center
      • Yakima, Washington, Stany Zjednoczone, 98902
        • North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
    • West Virginia
      • Bridgeport, West Virginia, Stany Zjednoczone, 26330
        • United Hospital Center
      • Charleston, West Virginia, Stany Zjednoczone, 25304
        • Vandalia Health/CAMC Institute for Academic Medicine
      • Morgantown, West Virginia, Stany Zjednoczone, 26506
        • West Virginia University Healthcare
      • Parkersburg, West Virginia, Stany Zjednoczone, 26101
        • Camden Clark Medical Center
    • Wisconsin
      • Appleton, Wisconsin, Stany Zjednoczone, 54911
        • ThedaCare Regional Cancer Center
      • Ashland, Wisconsin, Stany Zjednoczone, 54806
        • Duluth Clinic Ashland
      • Ashland, Wisconsin, Stany Zjednoczone, 54806
        • Northwest Wisconsin Cancer Center
      • Burlington, Wisconsin, Stany Zjednoczone, 53105
        • Aurora Cancer Care-Southern Lakes VLCC
      • Eau Claire, Wisconsin, Stany Zjednoczone, 54701
        • Marshfield Medical Center-EC Cancer Center
      • Eau Claire, Wisconsin, Stany Zjednoczone, 54701
        • HSHS Sacred Heart Hospital
      • Fond du Lac, Wisconsin, Stany Zjednoczone, 54937
        • Aurora Health Center-Fond du Lac
      • Germantown, Wisconsin, Stany Zjednoczone, 53022
        • Aurora Health Care Germantown Health Center
      • Grafton, Wisconsin, Stany Zjednoczone, 53024
        • Aurora Cancer Care-Grafton
      • Green Bay, Wisconsin, Stany Zjednoczone, 54311
        • Aurora BayCare Medical Center
      • Green Bay, Wisconsin, Stany Zjednoczone, 54301
        • Saint Vincent Hospital Cancer Center Green Bay
      • Green Bay, Wisconsin, Stany Zjednoczone, 54303
        • Saint Vincent Hospital Cancer Center at Saint Mary's
      • Green Bay, Wisconsin, Stany Zjednoczone, 54301
        • Bellin Memorial Hospital
      • Hayward, Wisconsin, Stany Zjednoczone, 54843
        • Essentia Health-Hayward Clinic
      • Johnson Creek, Wisconsin, Stany Zjednoczone, 53038
        • University of Wisconsin Carbone Cancer Center - Johnson Creek
      • Kenosha, Wisconsin, Stany Zjednoczone, 53142
        • Aurora Cancer Care-Kenosha South
      • Madison, Wisconsin, Stany Zjednoczone, 53792
        • University of Wisconsin Carbone Cancer Center - University Hospital
      • Marinette, Wisconsin, Stany Zjednoczone, 54143
        • Aurora Bay Area Medical Group-Marinette
      • Marshfield, Wisconsin, Stany Zjednoczone, 54449
        • Marshfield Medical Center-Marshfield
      • Milwaukee, Wisconsin, Stany Zjednoczone, 53209
        • Aurora Cancer Care-Milwaukee
      • Milwaukee, Wisconsin, Stany Zjednoczone, 53215
        • Aurora Saint Luke's Medical Center
      • Milwaukee, Wisconsin, Stany Zjednoczone, 53233
        • Aurora Sinai Medical Center
      • Minocqua, Wisconsin, Stany Zjednoczone, 54548
        • Marshfield Medical Center - Minocqua
      • New Richmond, Wisconsin, Stany Zjednoczone, 54017
        • Cancer Center of Western Wisconsin
      • Oshkosh, Wisconsin, Stany Zjednoczone, 54904
        • Vince Lombardi Cancer Clinic - Oshkosh
      • Racine, Wisconsin, Stany Zjednoczone, 53406
        • Aurora Cancer Care-Racine
      • Rice Lake, Wisconsin, Stany Zjednoczone, 54868
        • Marshfield Medical Center-Rice Lake
      • Sheboygan, Wisconsin, Stany Zjednoczone, 53081
        • Vince Lombardi Cancer Clinic-Sheboygan
      • Spooner, Wisconsin, Stany Zjednoczone, 54801
        • Essentia Health-Spooner Clinic
      • Stevens Point, Wisconsin, Stany Zjednoczone, 54482
        • Marshfield Medical Center-River Region at Stevens Point
      • Sturgeon Bay, Wisconsin, Stany Zjednoczone, 54235-1495
        • Saint Vincent Hospital Cancer Center at Sturgeon Bay
      • Summit, Wisconsin, Stany Zjednoczone, 53066
        • Aurora Medical Center in Summit
      • Superior, Wisconsin, Stany Zjednoczone, 54880
        • Essentia Health Saint Mary's Hospital - Superior
      • Two Rivers, Wisconsin, Stany Zjednoczone, 54241
        • Vince Lombardi Cancer Clinic-Two Rivers
      • Wauwatosa, Wisconsin, Stany Zjednoczone, 53226
        • Aurora Cancer Care-Milwaukee West
      • West Allis, Wisconsin, Stany Zjednoczone, 53227
        • Aurora West Allis Medical Center
      • Weston, Wisconsin, Stany Zjednoczone, 54476
        • Marshfield Medical Center - Weston

Kryteria uczestnictwa

Badacze szukają osób, które pasują do określonego opisu, zwanego kryteriami kwalifikacyjnymi. Niektóre przykłady tych kryteriów to ogólny stan zdrowia danej osoby lub wcześniejsze leczenie.

Kryteria kwalifikacji

Wiek uprawniający do nauki

18 lat i starsze (Dorosły, Starszy dorosły)

Akceptuje zdrowych ochotników

Nie

Płeć kwalifikująca się do nauki

Wszystko

Opis

Inclusion Criteria:

  • STEP 1 RANDOMIZATION: Patients must be age >= 18 years

  • STEP 1 RANDOMIZATION: Patients must have histologically confirmed T1N1-3M0 or T2-3N0-2M0 esophageal or gastroesophageal junctional adenocarcinoma (Siewert I and II)

  • STEP 1 RANDOMIZATION: Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1

  • STEP 1 RANDOMIZATION: Patents must be deemed a surgical candidate by a thoracic surgeon, surgical oncologist, or surgeon who is qualified to perform an esophagectomy

  • STEP 1 RANDOMIZATION: Absolute neutrophil count >= 1,500/mcL (within less than or equal to 14 days prior to randomization)

  • STEP 1 RANDOMIZATION: Platelets >= 100,000/mcL (within less than or equal to 14 days prior to randomization)

  • STEP 1 RANDOMIZATION: Total bilirubin =< institutional upper limit of normal (ULN) (within less than or equal to 14 days prior to randomization)

  • STEP 1 RANDOMIZATION: Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x institutional ULN (within less than or equal to 14 days prior to randomization)

  • STEP 1 RANDOMIZATION: Serum creatinine =< 1.5 x institutional ULN (within less than or equal to 14 days prior to randomization)

  • STEP 1 RANDOMIZATION: Hemoglobin (Hgb) >= 9 g/dL (within less than or equal to 14 days prior to randomization)

  • STEP 1 RANDOMIZATION: Leukocytes >= 3,000/mm^3 (within less than or equal to 14 days prior to randomization)

  • STEP 1 RANDOMIZATION: Patients may not have received prior chemotherapy or radiation therapy for management for this malignancy

  • STEP 1 RANDOMIZATION: Patients may not have received prior immunotherapy for management of this malignancy or for any other past malignancy

  • STEP 1 RANDOMIZATION: Patients must have no contraindication to receiving either carboplatin or paclitaxel chemotherapy

  • STEP 1 RANDOMIZATION: Patients must have no contraindication to receiving radiation therapy

  • STEP 1 RANDOMIZATION: Patients with active autoimmune disease or history of autoimmune disease that might recur, which may affect vital organ function or require immune suppressive treatment including systemic corticosteroids, must be excluded. These include but are not limited to patients with a history of immune related neurologic disease, multiple sclerosis, autoimmune (demyelinating) neuropathy, Guillain-Barre syndrome, myasthenia gravis; systemic autoimmune disease such as systemic lupus erythematosus (SLE), connective tissue disease, scleroderma, inflammatory bowel disease (IBD), Crohn's, ulcerative colitis, hepatitis; and patients with a history of toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome, or phospholipid syndrome must be excluded because of the risk of recurrence or exacerbation of disease. Patients with vitiligo, endocrine deficiencies including thyroiditis managed with replacement hormones including physiologic corticosteroids are eligible. Patients with rheumatoid arthritis and other arthropathies, Sjogren's syndrome and psoriasis controlled with topical medication and patients with positive serology, such as antinuclear antibodies (ANA), anti-thyroid antibodies must be evaluated for the presence of target organ involvement and potential need for systemic treatment but should otherwise be eligible

  • STEP 1 RANDOMIZATION: Patients are permitted to enroll if they have vitiligo, type I diabetes mellitus, residual hypothyroidism due to autoimmune condition only requiring hormone replacement, psoriasis not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger (precipitating event)

  • STEP 1 RANDOMIZATION: Patient must NOT have previous or concurrent malignancy. Exceptions are made for patients who meet any of the following conditions:

    • Non-melanoma skin cancer, in situ cervical cancer, superficial bladder cancer, or breast cancer in situ OR
    • Prior malignancy completely excised or removed and patient has been continuously disease free for > 5 years OR
    • Date of last evidence of disease

  • STEP 1 RANDOMIZATION: Patients must not have a condition requiring systemic treatment with either corticosteroids (> 10 mg/day prednisone equivalents) or other immunosuppressive medications within 14 days of study drug administration. Inhaled or topical steroids and adrenal replacement doses =< 10 mg/day prednisone equivalents are permitted in the absence of active autoimmune disease

  • STEP 1 RANDOMIZATION: Patients must have adequate cardiac function including electrocardiogram (EKG) and echocardiogram for any patient with a history of congestive heart failure (CHF) or at risk because of underlying cardiovascular disease or exposure to cardiotoxic drugs

  • STEP 1 RANDOMIZATION: For patients with evidence of uncontrolled CHF, myocardial infarction (MI), cardiomyopathy, or myositis, require a cardiac evaluation and clearance including lab tests and cardiology consultation (EKG, creatinine phosphokinase [CPK], troponin, and echocardiogram)

  • STEP 1 RANDOMIZATION: Patients must not have a positive test result for hepatitis B virus surface antigen (HBV sAg) or hepatitis C virus ribonucleic acid (HCV RNA) indicating acute or chronic infection. Testing should be conducted to determine eligibility

  • STEP 1 RANDOMIZATION: Patients with a known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) must have no detectable viral load on a stable anti-viral regimen

  • STEP 1 RANDOMIZATION: Patients must not be receiving any other investigational agents

  • STEP 1 RANDOMIZATION: Patients with an uncontrolled intercurrent illness such as ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia or psychiatric illness/social situations that would limit compliance with study requirements will be excluded

  • STEP 1 RANDOMIZATION: Patients must not be pregnant or breast-feeding due to potential harm to an unborn fetus and possible risk for adverse events in nursing infants from carboplatin, paclitaxel, ipilimumab or nivolumab

    • All patients of childbearing potential must have a blood test or urine study done within 2 weeks prior to randomization to rule out pregnancy. Those enrolled on Arm B with nivolumab must agree to have a pregnancy test (minimum sensitivity 25 IU/L or equivalent units of human chorionic gonadotropin [HCG]) within 24 hours of starting nivolumab to rule out pregnancy
    • A patient of childbearing potential is defined as anyone, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)

  • STEP 1 RANDOMIZATION: Patients of childbearing potential must not expect to conceive children by either abstaining from sexual intercourse for the duration of their participation in the study or by agreeing to use both double barrier contraception and birth control pills or implants for at least one month prior to the start of the study drug and continuing for 5 months after the last dose of study drug. Investigators shall counsel patients of childbearing potential on the importance of pregnancy prevention and the implications of an unexpected pregnancy

  • STEP 2 RANDOMIZATION: Patient registration must not exceed 12 weeks from time of esophagectomy

  • STEP 2 RANDOMIZATION: Patients must have a post-operative ECOG performance status of 0-2

  • STEP 2 RANDOMIZATION: Absolute neutrophil count >= 1,500/mcL (within less than or equal to 14 days prior to randomization)

  • STEP 2 RANDOMIZATION: Platelets >= 100,000/mcL (within less than or equal to 14 days prior to randomization)

  • STEP 2 RANDOMIZATION: Total bilirubin =< institutional upper limit of normal (ULN) (within less than or equal to 14 days prior to randomization)

  • STEP 2 RANDOMIZATION: AST (SGOT)/ ALT (SGPT) =< 2.5 x institutional ULN (within less than or equal to 14 days prior to randomization)

  • STEP 2 RANDOMIZATION: Serum creatinine =< 1.5 x institutional ULN (within less than or equal to 14 days prior to randomization)

  • STEP 2 RANDOMIZATION: Patients must be disease free following esophagectomy as is demonstrated by having no evidence of disease on a post-surgical CT scan. Patients must also have a negative surgical margin (R0 resection)

  • STEP 2 RANDOMIZATION: Patients must not have an active, known or suspected autoimmune disease or a condition requiring treatment with steroids or immunosuppressive agents. Patients are permitted to enroll if they have vitiligo, type I diabetes mellitus, residual hypothyroidism due to autoimmune condition only requiring hormone replacement, psoriasis not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger

  • STEP 2 RANDOMIZATION: Patients must not have a condition requiring systemic treatment with either corticosteroids (> 10 mg/day prednisone equivalents) or other immunosuppressive medications with 14 days of study drug administration. Inhaled or topical steroids and adrenal replacement doses > 10 mg/day prednisone equivalents are permitted in the absence of active autoimmune disease

  • STEP 2 RANDOMIZATION: Patients must not be receiving any other investigational agents

  • STEP 2 RANDOMIZATION: Patients with an uncontrolled intercurrent illness such as ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia or psychiatric illness/social situations that would limit compliance with study requirements will be excluded

  • STEP 2 RANDOMIZATION: Patients must not be pregnant or breast-feeding due to potential harm to an unborn fetus and possible risks for adverse events in nursing infants from nivolumab or ipilimumab

    • All patients of childbearing potential must have a blood test or urine study done (minimum sensitivity 25 IU/L or equivalent units of HCG) within 2 weeks prior to randomization to rule out pregnancy. All patients must also agree to have a pregnancy test (minimum sensitivity 25 IU/L or equivalent units of HCG) within 24 hours of starting nivolumab to rule out pregnancy. Those enrolled on Arm D with ipilimumab must agree to have pregnancy tests within 72 hours of each ipilimumab administration to rule out pregnancy

  • STEP 2 RANDOMIZATION: Patients of childbearing potential must not expect to conceive children by either abstaining from sexual intercourse for the duration of their participation in the study or by agreeing to use both double barrier contraception and birth control pills or implants for at least one month prior to the start of the study drug and continuing for 5 months after the last dose of study drug. Investigators shall counsel patients of childbearing potential on the importance of pregnancy prevention and the implications of an unexpected pregnancy

Plan studiów

Ta sekcja zawiera szczegółowe informacje na temat planu badania, w tym sposób zaprojektowania badania i jego pomiary.

Jak projektuje się badanie?

Szczegóły projektu

  • Główny cel: Leczenie
  • Przydział: Randomizowane
  • Model interwencyjny: Przydział równoległy
  • Maskowanie: Brak (otwarta etykieta)

Broń i interwencje

Grupa uczestników / Arm
Interwencja / Leczenie
Eksperymentalny: Arm A (carboplatin, paclitaxel, radiation therapy)

Patients receive carboplatin IV and paclitaxel IV once weekly and undergo radiation therapy QD (Monday-Friday) beginning on day 1 of each cycle. Cycles repeat every week for up to 5 weeks in the absence of disease progression or unacceptable toxicity. Patients undergo a CT or PET scan during screening and follow-up and undergo collection of blood samples throughout the trial.
Lek: Carboplatin

Given IV

Inne nazwy:
  • Blastokarb
  • Karboplat
  • Karboplatyna Hexal
  • Karboplatyna
  • Karbozyna
  • Karbozol
  • Carbotec
  • CBDCA
  • Displata
  • Erkar
  • JM-8
  • Nealorin
  • Nowoplatyna
  • Paraplatyna
  • Paraplatyna AQ
  • Platyna
  • Rybokarbo
  • JM8
Lek: Paclitaxel

Given IV

Inne nazwy:
  • Taksol
  • Anzatax
  • Asotaks
  • Bristaksol
  • Praksel
  • Taxol Konzentrat
Procedura: Computed Tomography

Undergo CT scan

Inne nazwy:
  • Tomografia komputerowa
  • KOT
  • Skanowanie CAT
  • Tomografia komputerowa osiowa
  • Komputerowa tomografia osiowa
  • tomografia
  • Komputerowa tomografia osiowa (zabieg)
  • Tomografia komputerowa (CT).
  • Diagnostyczny skan CAT
  • Diagnostyczny typ usługi skanowania CAT
Procedura: Positron Emission Tomography

Undergo PET scan

Inne nazwy:
  • Obrazowanie medyczne, pozytonowa tomografia emisyjna
  • ZWIERZAK DOMOWY
  • Skanowanie zwierzęcia
  • Skan pozytonowej tomografii emisyjnej
  • Pozytonowa emisyjna tomografia komputerowa
  • PT
  • Pozytronowa tomografia emisyjna (zabieg)
Procedura: Biospecimen Collection

Undergo collection of blood sample

Inne nazwy:
  • Pobieranie próbek biologicznych
  • Zebrano próbki biologiczne
  • Kolekcja próbek
Promieniowanie: Radiation Therapy

Undergo radiation therapy

Inne nazwy:
  • Radioterapia raka
  • RODZAJ_ENERGII
  • Naświetlać
  • Napromieniowany
  • Naświetlanie
  • Promieniowanie
  • Radioterapia, NOS
  • Radioterapia
  • RT
  • Terapia, promieniowanie
  • Rodzaj energii
Eksperymentalny: Arm B (carboplatin, paclitaxel, radiation therapy, nivolumab)

Patients receive carboplatin, paclitaxel, and radiation therapy as in Arm A. Patients also receive nivolumab IV over 30 minutes on days 1 and 15 of each cycle. Cycles repeat every week for up to 5 weeks in the absence of disease progression or unacceptable toxicity. Patients undergo a CT or PET scan during screening and follow-up and undergo collection of blood samples throughout the trial.
Lek: Carboplatin

Given IV

Inne nazwy:
  • Blastokarb
  • Karboplat
  • Karboplatyna Hexal
  • Karboplatyna
  • Karbozyna
  • Karbozol
  • Carbotec
  • CBDCA
  • Displata
  • Erkar
  • JM-8
  • Nealorin
  • Nowoplatyna
  • Paraplatyna
  • Paraplatyna AQ
  • Platyna
  • Rybokarbo
  • JM8
Lek: Paclitaxel

Given IV

Inne nazwy:
  • Taksol
  • Anzatax
  • Asotaks
  • Bristaksol
  • Praksel
  • Taxol Konzentrat
Biologiczny: Nivolumab

Given IV

Inne nazwy:
  • BMS-936558
  • MDX-1106
  • NIWO
  • ONO-4538
  • Opdivo
  • CMAB819
  • Niwolumab biopodobny CMAB819
  • MDX 1106
  • MDX1106
  • BMS 936558
  • ABP 206
  • Niwolumab Biopodobny ABP 206
  • BCD-263
  • Niwolumab Biopodobny BCD-263
  • BMS936558
  • ONO 4538
  • ONO4538
Procedura: Computed Tomography

Undergo CT scan

Inne nazwy:
  • Tomografia komputerowa
  • KOT
  • Skanowanie CAT
  • Tomografia komputerowa osiowa
  • Komputerowa tomografia osiowa
  • tomografia
  • Komputerowa tomografia osiowa (zabieg)
  • Tomografia komputerowa (CT).
  • Diagnostyczny skan CAT
  • Diagnostyczny typ usługi skanowania CAT
Procedura: Positron Emission Tomography

Undergo PET scan

Inne nazwy:
  • Obrazowanie medyczne, pozytonowa tomografia emisyjna
  • ZWIERZAK DOMOWY
  • Skanowanie zwierzęcia
  • Skan pozytonowej tomografii emisyjnej
  • Pozytonowa emisyjna tomografia komputerowa
  • PT
  • Pozytronowa tomografia emisyjna (zabieg)
Procedura: Biospecimen Collection

Undergo collection of blood sample

Inne nazwy:
  • Pobieranie próbek biologicznych
  • Zebrano próbki biologiczne
  • Kolekcja próbek
Promieniowanie: Radiation Therapy

Undergo radiation therapy

Inne nazwy:
  • Radioterapia raka
  • RODZAJ_ENERGII
  • Naświetlać
  • Napromieniowany
  • Naświetlanie
  • Promieniowanie
  • Radioterapia, NOS
  • Radioterapia
  • RT
  • Terapia, promieniowanie
  • Rodzaj energii
Eksperymentalny: Arm C (nivolumab)

Patients receive nivolumab IV over 30 minutes on day 1 of each cycle. Treatment repeats every 4 weeks for up to 13 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo a CT scan and collection of blood samples throughout the trial.
Biologiczny: Nivolumab

Given IV

Inne nazwy:
  • BMS-936558
  • MDX-1106
  • NIWO
  • ONO-4538
  • Opdivo
  • CMAB819
  • Niwolumab biopodobny CMAB819
  • MDX 1106
  • MDX1106
  • BMS 936558
  • ABP 206
  • Niwolumab Biopodobny ABP 206
  • BCD-263
  • Niwolumab Biopodobny BCD-263
  • BMS936558
  • ONO 4538
  • ONO4538
Procedura: Computed Tomography

Undergo CT scan

Inne nazwy:
  • Tomografia komputerowa
  • KOT
  • Skanowanie CAT
  • Tomografia komputerowa osiowa
  • Komputerowa tomografia osiowa
  • tomografia
  • Komputerowa tomografia osiowa (zabieg)
  • Tomografia komputerowa (CT).
  • Diagnostyczny skan CAT
  • Diagnostyczny typ usługi skanowania CAT
Procedura: Biospecimen Collection

Undergo collection of blood sample

Inne nazwy:
  • Pobieranie próbek biologicznych
  • Zebrano próbki biologiczne
  • Kolekcja próbek
Eksperymentalny: Arm D (nivolumab, ipilimumab)

Patients receive nivolumab as in Arm C and receive ipilimumab IV over 90 minutes on day 1 of cycles 1 and 4 and day 15 of cycles 2 and 5. Treatment repeats every 4 weeks for up to 13 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo a CT scan and collection of blood samples throughout the trial.
Biologiczny: Ipilimumab

Given IV

Inne nazwy:
  • Przeciwciało monoklonalne antycytotoksyczne związane z limfocytami T-4
  • BMS-734016
  • Ipilimumab Biopodobny CS1002
  • MDX-010
  • MDX-CTLA4
  • Yervoy
  • MDX010
  • BMS734016
  • BMS 734016
Biologiczny: Nivolumab

Given IV

Inne nazwy:
  • BMS-936558
  • MDX-1106
  • NIWO
  • ONO-4538
  • Opdivo
  • CMAB819
  • Niwolumab biopodobny CMAB819
  • MDX 1106
  • MDX1106
  • BMS 936558
  • ABP 206
  • Niwolumab Biopodobny ABP 206
  • BCD-263
  • Niwolumab Biopodobny BCD-263
  • BMS936558
  • ONO 4538
  • ONO4538
Procedura: Computed Tomography

Undergo CT scan

Inne nazwy:
  • Tomografia komputerowa
  • KOT
  • Skanowanie CAT
  • Tomografia komputerowa osiowa
  • Komputerowa tomografia osiowa
  • tomografia
  • Komputerowa tomografia osiowa (zabieg)
  • Tomografia komputerowa (CT).
  • Diagnostyczny skan CAT
  • Diagnostyczny typ usługi skanowania CAT
Procedura: Biospecimen Collection

Undergo collection of blood sample

Inne nazwy:
  • Pobieranie próbek biologicznych
  • Zebrano próbki biologiczne
  • Kolekcja próbek

Co mierzy badanie?

Podstawowe miary wyniku

Miara wyniku
Opis środka
Ramy czasowe
Pathologic complete response (Step I)
Ramy czasowe: Up to 5 weeks

The study with compare the pathologic complete response of Arm A and Arm B using a one-sided 0.10 level chi-squared test for proportions.
Up to 5 weeks
Disease-free survival (DFS) (Step 2)
Ramy czasowe: From the adjuvant treatment randomization assessed for up to 7 years

DFS measured from the adjuvant treatment randomization will be the endpoint of the adjuvant portion of the study and to achieve the desired power it is expected that patients will be followed for an additional year post completion of accrual to the adjuvant portion. The DFS comparison will be between patients randomized to Arm C (nivolumab) versus Arm D (nivolumab plus ipilimumab) using a one-sided 0.10 level stratified log rank test.
From the adjuvant treatment randomization assessed for up to 7 years

Miary wyników drugorzędnych

Miara wyniku
Opis środka
Ramy czasowe
Incidence of adverse events
Ramy czasowe: Up to 7 years

Graded according to Common Terminology Criteria for Adverse Events version 5.0. Toxicity will be evaluated among all treated patients regardless of eligibility and interim analyses of toxicity are performed twice yearly. The study will have sufficient precision to provide 95% confidence intervals on toxicity
Up to 7 years
Overall survival
Ramy czasowe: From the time of first randomization up to 7 years

Analyses will be descriptive in nature and will not follow any formal interim monitoring.
From the time of first randomization up to 7 years
DFS
Ramy czasowe: From the time of first randomization up to 7 years

The DFS comparison will be between patients randomized to Arm C (nivolumab) versus Arm D (nivolumab plus ipilimumab) using a one-sided 0.10 level stratified log rank test.
From the time of first randomization up to 7 years

Inne miary wyników

Miara wyniku
Opis środka
Ramy czasowe
Percent change in mean volumetric apparent diffusion coefficient (ADC)
Ramy czasowe: Baseline to mid-treatment

The study will assess the area under the receiver operating characteristic curve of the changes of ADC value.
Baseline to mid-treatment

Współpracownicy i badacze

Tutaj znajdziesz osoby i organizacje zaangażowane w to badanie.

Sponsor

National Cancer Institute (NCI)

Śledczy

  • Główny śledczy: Jennifer R Eads, ECOG-ACRIN Cancer Research Group

Daty zapisu na studia

Daty te śledzą postęp w przesyłaniu rekordów badań i podsumowań wyników do ClinicalTrials.gov. Zapisy badań i zgłoszone wyniki są przeglądane przez National Library of Medicine (NLM), aby upewnić się, że spełniają określone standardy kontroli jakości, zanim zostaną opublikowane na publicznej stronie internetowej.

Główne daty studiów

Rozpoczęcie studiów (Rzeczywisty)

3 maja 2019

Zakończenie podstawowe (Szacowany)

31 marca 2027

Ukończenie studiów (Szacowany)

31 marca 2027

Daty rejestracji na studia

Pierwszy przesłany

27 lipca 2018

Pierwszy przesłany, który spełnia kryteria kontroli jakości

27 lipca 2018

Pierwszy wysłany (Rzeczywisty)

30 lipca 2018

Aktualizacje rekordów badań

Ostatnia wysłana aktualizacja (Rzeczywisty)

2 listopada 2026

Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości

30 października 2026

Ostatnia weryfikacja

1 września 2026

Więcej informacji

Terminy związane z tym badaniem

Dodatkowe istotne warunki MeSH

Inne numery identyfikacyjne badania

  • NCI-2018-01575
  • U10CA180820 (Grant/umowa NIH USA)
  • NCI-2018-01575 (Identyfikator rejestru: CTRP (Clinical Trial Reporting Program))
  • EA2174 (Inny identyfikator: CTEP)
  • EA2174 (Inny identyfikator: ECOG-ACRIN Cancer Research Group)

Plan dla danych uczestnika indywidualnego (IPD)

Planujesz udostępniać dane poszczególnych uczestników (IPD)?

TAK

Opis planu IPD

NCI is committed to sharing data in accordance with NIH policy. For more details on how clinical trial data is shared, access the link to the NIH data sharing policy page

Informacje o lekach i urządzeniach, dokumenty badawcze

Bada produkt leczniczy regulowany przez amerykańską FDA

Tak

Bada produkt urządzenia regulowany przez amerykańską FDA

Nie

Te informacje zostały pobrane bezpośrednio ze strony internetowej clinicaltrials.gov bez żadnych zmian. Jeśli chcesz zmienić, usunąć lub zaktualizować dane swojego badania, skontaktuj się z register@clinicaltrials.gov. Gdy tylko zmiana zostanie wprowadzona na stronie clinicaltrials.gov, zostanie ona automatycznie zaktualizowana również na naszej stronie internetowej .

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