- ICH GCP
- Rejestr badań klinicznych w USA
- Badanie kliniczne NCT07687316
Mental Effort During Low Load Resistance Training in Older Adults
The Effect of Maximal Mental Effort During Resistance Training on Physical Function and Motor Unit Behavior in Older Adults
The goal of this clinical trial is to determine the effect of maximal mental effort combined with low-intensity resistance training on strength and neuromuscular function in older adults. The main questions it aims to answer are:
- Does low-intensity resistance training in combination with maximal mental effort increase strength more than low intensity resistance training alone?
- Does low-intensity resistance training in combination with maximal mental effort improve neuromuscular function more than low intensity resistance training alone?
Participants will be randomly assigned to 1 of 3 groups:
- Low intensity resistance training
- Low intensity resistance training with maximal mental effort
- Control Researchers will compare groups to determine differences in changes in strength, neuromuscular function, and body composition.
Przegląd badań
Status
Warunki
Szczegółowy opis
Participants in both training groups will perform 8 weeks of low intensity, whole-body resistance training. Participants in the control group will participate in all testing procedures but not perform any training. Participants from all groups will be instructed to otherwise maintain their normal physical activity levels and dietary habits.
All training sessions will be supervised by research personnel at a Kennesaw State University fitness center. Participants will complete 2 training sessions per week for 8 weeks. Each training session will last about 45-60 minutes and consist of 5 exercises, including both multi-joint (leg press, chest press, back row) and single-joint (knee extension, bicep curl) exercises. Participants will perform 2 sets of 15 repetitions for each exercise for the first 2 weeks, then volume will be increased by progressing to 3 sets for the remaining 6 weeks. There will be a 60-second rest interval between sets and a similar tempo will be used between groups.
Both training groups will perform the same training protocol, but participants in the maximal mental effort group will mentally urge their muscles to contract maximally during each repetition. That is, despite using a low intensity, participants will imagine the feeling of maximal muscle contraction of the primary muscles during each repetition.
Several measures of strength, neuromuscular function, physical function, and body composition will be measured before and after the training or control period.
Typ studiów
Zapisy (Szacowany)
Faza
- Nie dotyczy
Kontakty i lokalizacje
Kontakt w sprawie studiów
- Nazwa: Garrett Hester Professor of Exercise Science
- Numer telefonu: 470-578-4267
- E-mail: ghester4@kennesaw.edu
Lokalizacje studiów
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-
Georgia
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Kennesaw, Georgia, Stany Zjednoczone, 30144
- Rekrutacyjny
- Kennesaw State University
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Kontakt:
- Garrett Hester
- Numer telefonu: 470-578-4267
- E-mail: ghester4@kennesaw.edu
-
-
Kryteria uczestnictwa
Kryteria kwalifikacji
Wiek uprawniający do nauki
- Starszy dorosły
Akceptuje zdrowych ochotników
Opis
Inclusion Criteria:
- Body mass index between 18.5 - 33 kg·m2
- No structured physical activity in past 2 years
- Any unstable condition contradicting exercise
- Independently walk with or without assistive device
- No significant cognitive impairment
Exclusion Criteria:
- Score of 22 or lower on Montreal Cognitive Assessment
- Missing more than 3 training sessions (training groups only)
- Pacemaker
- Unstable angina
- Symptomatic heart failure
- Uncontrolled arrythmias
- Uncontrolled hypertension (greater or equal to 160/90)
- Myocardial infarction in the past 6 months
- Uncontrolled type 2 diabetes
- Type 1 diabetes
- Severe or unstable pulmonary conditions,
- Currently on supplemental oxygen therapy
- Severe hearing loss or visual impairment
- Alzheimer's Disease or significant cognitive impairment
- Stroke in the past 6 months or ongoing stroke-induced motor impairment
- Any neurological (e.g., Parkinson's) condition affecting motor control
- Undergoing chemotherapy
- Surgery in past 6 months
- Musculoskeletal injury in the past 6 months
- Terminal illness
- Stage 3 or greater chronic kidney disease
Plan studiów
Jak projektuje się badanie?
Szczegóły projektu
- Główny cel: Inny
- Przydział: Randomizowane
- Model interwencyjny: Przydział równoległy
- Maskowanie: Pojedynczy
Broń i interwencje
Grupa uczestników / Arm |
Interwencja / Leczenie |
|---|---|
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Brak interwencji: Kontrola
Grupa ta nie będzie wykonywać żadnych treningów i utrzymywać regularny poziom aktywności fizycznej.
|
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Eksperymentalny: Low Intensity Resistance Training
This group will perform low intensity, whole-body resistance training.
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This training intervention will be 8 weeks of low intensity resistance training, including whole-body and isolated muscle exercises.
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Eksperymentalny: Low Intensity Resistance Training with Maximal Mental Effort
This group will perform low intensity, whole-body resistance training with maximal mental effort during muscle contraction.
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This training intervention will be 8 weeks of low intensity resistance training, including whole-body and isolated muscle exercises, where participants will perform maximal mental effort by imagining maximal muscle contraction during each exercise.
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Co mierzy badanie?
Podstawowe miary wyniku
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
|
Change in isokinetic strength of the knee extensors at 60 degrees per second
Ramy czasowe: Baseline, Week 8
|
Dynamic strength of the knee extensors contracting at a constant velocity
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Baseline, Week 8
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Miary wyników drugorzędnych
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
|
Change in isokinetic knee extensor muscle activation as measured by electromyography amplitude
Ramy czasowe: Baseline, Week 8
|
Electromyography root mean square during isokinetic contraction divided by root mean square during isometric contraction
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Baseline, Week 8
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Change in isometric knee extensor strength as measured by newton-meters of torque
Ramy czasowe: Baseline, Week 8
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Isometric strength of a muscle
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Baseline, Week 8
|
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Change in knee extensor muscle activation as measured by electromyography amplitude
Ramy czasowe: Baseline, Week 8
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A measure of the capacity at which the muscle is activated by the nervous system
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Baseline, Week 8
|
|
Change in motor unit firing rate as measured relative to the motor unit recruitment threshold
Ramy czasowe: Baseline, Week 8
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A measure of how nervous system input produces force output during an isometric contraction
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Baseline, Week 8
|
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Change in motor unit action potential size as measured relative to the motor unit recruitment threshold
Ramy czasowe: Baseline, Week 8
|
A measure of how nervous system input produces force output during an isometric contraction
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Baseline, Week 8
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Change in handgrip strength as measured in kilograms of force
Ramy czasowe: Baseline, Week 8
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Upper-body strength as measured by a handgrip dynamometer
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Baseline, Week 8
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Change in walking speed as measured by time taken to walk 4 meters
Ramy czasowe: Baseline, Week 8
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Measure of lower-body physical function
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Baseline, Week 8
|
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Change in chair rise performance as measured by number of chair rises performed in 30 seconds
Ramy czasowe: Baseline, Week 8
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Measure of lower-body physical function
|
Baseline, Week 8
|
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Change in bicep curl strength as measured by load lifted in pounds
Ramy czasowe: Baseline, Week 8
|
Maximum dumbbell load lifted successfully throughout the range of motion of a bicep curl
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Baseline, Week 8
|
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Change in dynamic strength of the lower body muscles during the leg press as measured by load lifted in pounds for 5 repetitions
Ramy czasowe: Baseline, Week 5, Week 8
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Measure of dynamic strength during the leg press exercise
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Baseline, Week 5, Week 8
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Change in muscle composition as measured by ultrasound-derived grey-scale analysis
Ramy czasowe: Baseline, Week 8
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Echo-intensity value derived from grey-scale analysis is indicative of amount of non-contractile tissue in muscle
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Baseline, Week 8
|
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Change in skeletal muscle size as measured by ultrasound-derived cross-sectional area
Ramy czasowe: Baseline, Week 8
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Size of a muscle
|
Baseline, Week 8
|
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Change in fat mass as measured by kilograms
Ramy czasowe: Baseline, Week 8
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Amount of fat tissue a person possesses estimated by bioelectrical impedance analysis
|
Baseline, Week 8
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Change in fat-free mass as measured by kilograms
Ramy czasowe: Baseline, Week 8
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Amount of non-fat tissue a person possesses estimated by bioelectrical impedance analysis
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Baseline, Week 8
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Change in body fat percentage as measured by fat tissue relative to fat-free tissue
Ramy czasowe: Baseline, Week 8
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Relative amount of body fat a person possesses estimated by bioelectrical impedance analysis
|
Baseline, Week 8
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Change in cognitive function as measured by the Montreal Cognitive Assessment
Ramy czasowe: Baseline, Week 8
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Assessment of cognitive function where 0 is the lowest score and 30 is the highest score and a higher score represents higher cognitive function.
|
Baseline, Week 8
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Współpracownicy i badacze
Sponsor
Daty zapisu na studia
Główne daty studiów
Rozpoczęcie studiów (Rzeczywisty)
Zakończenie podstawowe (Szacowany)
Ukończenie studiów (Szacowany)
Daty rejestracji na studia
Pierwszy przesłany
Pierwszy przesłany, który spełnia kryteria kontroli jakości
Pierwszy wysłany (Rzeczywisty)
Aktualizacje rekordów badań
Ostatnia wysłana aktualizacja (Rzeczywisty)
Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości
Ostatnia weryfikacja
Więcej informacji
Terminy związane z tym badaniem
Słowa kluczowe
Dodatkowe istotne warunki MeSH
Inne numery identyfikacyjne badania
- 2026-Hester
Plan dla danych uczestnika indywidualnego (IPD)
Planujesz udostępniać dane poszczególnych uczestników (IPD)?
Informacje o lekach i urządzeniach, dokumenty badawcze
Bada produkt leczniczy regulowany przez amerykańską FDA
Bada produkt urządzenia regulowany przez amerykańską FDA
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