Platelet-rich fibrin application in dentistry: a literature review

Abstract

The development of bioactive surgical additives to regulate the inflammation and increase the speed of healing process is one of the great challenges in clinical research. In this sense, platelet rich fibrin (PRF) appears as a natural and satisfactory alternative with favorable results and low risks. The following review attempts to summarize the relevant literature regarding the technique of using PRF, focusing on its preparation, advantages, and disadvantages of using it in clinical applications. PRF alone or in combination with other biomaterials seems to have several advantages and indications both for medicine and dentistry, due it is a minimally invasive technique with low risks and satisfactory clinical results.

Keywords: Blood platelet; bone regeneration; fibrin; oral surgery; platelet-rich fibrin.

Figures

Figure 1

Clinical use during a horizontal bone augmentation surgery. A. PRF clot in sterile gauze for serum release. B. Allograft mixed with PRF clot. C. Location of PRF + allograft in the alveolar ridge to augment in width. Note the PRF layer over the bone graft. D. Final suture. It was not necessary to expose the PRF membrane layer because in this case it was possible to bind the mucosal margins.