Prisons as reservoir for community transmission of tuberculosis, Brazil

Flávia P C Sacchi, Renata M Praça, Mariana B Tatara, Vera Simonsen, Lucilaine Ferrazoli, Mariana G Croda, Philip N Suffys, Albert I Ko, Jason R Andrews, Julio Croda, Flávia P C Sacchi, Renata M Praça, Mariana B Tatara, Vera Simonsen, Lucilaine Ferrazoli, Mariana G Croda, Philip N Suffys, Albert I Ko, Jason R Andrews, Julio Croda

Abstract

We conducted a population-based study of tuberculosis (TB) cases in Dourados, Brazil, to assess the relationship between incarceration and TB in the general population. Incarceration was associated with TB in an urban population; 54% of Mycobacterium tuberculosis strains were related to strains from persons in prisons. TB control in prisons is critical for reducing disease prevalence.

Keywords: Brazil; Mycobacterium tuberculosis; bacteria; case–control study; community transmission; epidemiology; genotyping; prisoners; reservoir; tuberculosis and other mycobacteria.

Figures

Figure 1
Figure 1
Flowchart for recruitment of patients with tuberculosis (TB) for case–control and molecular studies of prisons as reservoir for community transmission of tuberculosis, Brazil, June 2009–March 2013. *Eleven strains were not reactive after freezing, and 5 strains had 6110. SINAN, Sistema de Informação de Agravos de Notificação (National Notifiable Diseases Information System).
Figure 2
Figure 2
Temporal distribution of Mycobacterium tuberculosis strains isolated from the urban population, prisoners, and ex-prisoners in Dourados, Brazil, clustered by IS6110 restriction fragment length polymorphism analysis, June 2009–March 2013, and stratified by year of isolation and number of the identified cluster.

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