Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis

Ali A Mokdad, Alan D Lopez, Saied Shahraz, Rafael Lozano, Ali H Mokdad, Jeff Stanaway, Christopher J L Murray, Mohsen Naghavi, Ali A Mokdad, Alan D Lopez, Saied Shahraz, Rafael Lozano, Ali H Mokdad, Jeff Stanaway, Christopher J L Murray, Mohsen Naghavi

Abstract

Background: Liver cirrhosis is a major yet largely preventable and underappreciated cause of global health loss. Variations in cirrhosis mortality at the country level reflect differences in prevalence of risk factors such as alcohol use and hepatitis B and C infection. We estimated annual age-specific mortality from liver cirrhosis in 187 countries between 1980 and 2010.

Methods: We systematically collected vital registration and verbal autopsy data on liver cirrhosis mortality for the period 1980 to 2010. We corrected for misclassification of deaths, which included deaths attributed to improbable or nonfatal causes. We used ensemble models to estimate liver cirrhosis mortality with uncertainty by age, sex, country and year. We used out-of-sample predictive validity to select the optimal model.

Results: Global liver cirrhosis deaths increased from around 676,000 (95% uncertainty interval: 452,863 to 1,004,530) in 1980 to over 1 million (1,029,042; 670,216 to 1,554,530) in 2010 (about 2% of the global total). Over the same period, the age-standardized cirrhosis mortality rate decreased by 22%. This was largely driven by decreasing cirrhosis mortality rates in China, the US and countries in Western Europe. In 2010, Egypt, followed by Moldova, had the highest age-standardized cirrhosis mortality rates, 72.7 and 71.2 deaths per 100,000, respectively, while Iceland had the lowest. In Egypt, almost one-fifth (18.1%) of all deaths in males 45- to 54-years old were due to liver cirrhosis. Liver cirrhosis mortality in Mexico is the highest in Latin America. In France and Italy, liver cirrhosis mortality fell by 50% to 60%; conversely, in the United Kingdom, mortality increased by about one-third. Mortality from liver cirrhosis was also comparatively high in Central Asia countries, particularly Mongolia, Uzbekistan and Kyrgyzstan, and in parts of sub-Saharan Africa, notably Gabon.

Conclusions: Liver cirrhosis is a significant cause of global health burden, with more than one million deaths in 2010. Our study identifies areas with high and/or rapidly increasing mortality where preventive measures to control and reduce liver cirrhosis risk factors should be urgently strengthened.

Figures

Figure 1
Figure 1
Pre-corrected versus post-corrected liver cirrhosis deaths.
Figure 2
Figure 2
Population attributable fractions in liver cirrhosis by region in 1990 and 2010.
Figure 3
Figure 3
Liver cirrhosis deaths from 1980 to 2010 by region.
Figure 4
Figure 4
Age-adjusted liver cirrhosis mortality (per 100,000) for both sexes in 2010. ATG(Antigua and Barbuda), BRB(Barbados), COM(Comoros), DMA(Dominica), E Med(East Mediterranean), FJI(Fiji), FSM(Micronesia, Federated States of), GRD(Grenada), KIR(Kiribati), LCA(Saint Lucia), MDV(Maldives), MHL(Marshall Islands), MLT(Malta), MUS(Mauritius), PERS GULF(Persian Gulf), SGP(Singapore), SLB(Solomon Islands), SYC(Seychelles), TLS(Timor-Leste), TON(Tonga), TTO(Trinidad and Tobago), VCT(Saint Vincent and the Grenadines), VUT(Vanuatu), W AFR(West Africa), WSM(Samoa).
Figure 5
Figure 5
Percent change in age-adjusted liver cirrhosis mortality between 1980 and 2010. ATG(Antigua and Barbuda), BRB(Barbados), COM(Comoros), DMA(Dominica), E Med(East Mediterranean), FJI(Fiji), FSM(Micronesia, Federated States of), GRD(Grenada), KIR(Kiribati), LCA(Saint Lucia), MDV(Maldives), MHL(Marshall Islands), MLT(Malta), MUS(Mauritius), PERS GULF(Persian Gulf), SGP(Singapore), SLB(Solomon Islands), SYC(Seychelles), TLS(Timor-Leste), TON(Tonga), TTO(Trinidad and Tobago), VCT(Saint Vincent and the Grenadines), VUT(Vanuatu), W AFR(West Africa), WSM(Samoa).
Figure 6
Figure 6
Percent change in age-adjusted liver cirrhosis mortality between 1990 and 2000. ATG(Antigua and Barbuda), BRB(Barbados), COM(Comoros), DMA(Dominica), E Med(East Mediterranean), FJI(Fiji), FSM(Micronesia, Federated States of), GRD(Grenada), KIR(Kiribati), LCA(Saint Lucia), MDV(Maldives), MHL(Marshall Islands), MLT(Malta), MUS(Mauritius), PERS GULF(Persian Gulf), SGP(Singapore), SLB(Solomon Islands), SYC(Seychelles), TLS(Timor-Leste), TON(Tonga), TTO(Trinidad and Tobago), VCT(Saint Vincent and the Grenadines), VUT(Vanuatu), W AFR(West Africa), WSM(Samoa).

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Source: PubMed

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