The neurochemistry and social flow of singing: bonding and oxytocin

Jason R Keeler, Edward A Roth, Brittany L Neuser, John M Spitsbergen, Daniel J M Waters, John-Mary Vianney, Jason R Keeler, Edward A Roth, Brittany L Neuser, John M Spitsbergen, Daniel J M Waters, John-Mary Vianney

Abstract

Music is used in healthcare to promote physical and psychological well-being. As clinical applications of music continue to expand, there is a growing need to understand the biological mechanisms by which music influences health. Here we explore the neurochemistry and social flow of group singing. Four participants from a vocal jazz ensemble were conveniently sampled to sing together in two separate performances: pre-composed and improvised. Concentrations of plasma oxytocin and adrenocorticotropic hormone (ACTH) were measured before and after each singing condition to assess levels of social affiliation, engagement and arousal. A validated assessment of flow state was administered after each singing condition to assess participants' absorption in the task. The feasibility of the research methods were assessed and initial neurochemical data was generated on group singing. Mean scores of the flow state scale indicated that participants experienced flow in both the pre-composed (M = 37.06) and improvised singing conditions (M = 34.25), with no significant difference between conditions. ACTH concentrations decreased in both conditions, significantly so in the pre-composed singing condition, which may have contributed to the social flow experience. Mean plasma oxytocin levels increased only in response to improvised singing, with no significant difference between improvised and pre-composed singing conditions observed. The results indicate that group singing reduces stress and arousal, as measured by ACTH, and induces social flow in participants. The effects of pre-composed and improvised group singing on oxytocin are less clear. Higher levels of plasma oxytocin in the improvised condition may perhaps be attributed to the social effects of improvising musically with others. Further research with a larger sample size is warranted.

Keywords: ACTH; bonding; improvisation; music; oxytocin; singing; social flow; trust.

Figures

Figure 1
Figure 1
Study design.
Figure 2
Figure 2
The figure depicts individual concentrations of plasma adrenocorticotropic hormone (ACTH) at each time point measured during the standard performance (SP) and improvised performance (IP).
Figure 3
Figure 3
The figure depicts individual concentrations of plasma oxytocin (OT) at each time point measured during the standard performance (SP) and improvised performance (IP).
Figure 4
Figure 4
The figure depicts the relationship between plasma adrenocorticotropic hormone (ACTH) and oxytocin (OT) concentrations for each subject measured during pre and post-tests of the standard performance (SP) and improvised performance (IP). An inverse relationship between neuropeptide levels is demonstrated in 3 out of 4 subjects.

References

    1. Amico J. A., Ulbrecht J. S., Robinson A. G. (1987). Clearance studies of oxytocin in humans using radioimmunoassay measurements of the hormone in plasma and urine. J. Clin. Endocrinol. Metab. 6, 240–245. 10.1210/jcem-64-2-340
    1. Anshel A., Kipper D. A. (1988). The influence of group singing on trust and cooperation. J. Music Ther. 25, 145–155. 10.1093/jmt/25.3.145
    1. Bachen C. M., Raphael C. (2011). Social Flow and Learning in Digital Games: A Conceptual Model and Research Agenda. London: Springer.
    1. Baker F. A., MacDonald R. A. R. (2013). Flow, identity, achievement, satisfaction and ownership during therapeutic songwriting experiences with university students and retirees. Musicae Scientiae, 17, 131–146. 10.1177/1029864913476287
    1. Bakker A. B., Oerlemans W., Demerouti E., Slot B. B., Ali D. K. (2011). Flow and performance: A study among talented dutch soccer players. Psychol. Sport Exerc. 12, 442–450. 10.1016/j.psychsport.2011.02.003
    1. Bartz J. A., Zaki J., Bolger N., Ochsner K. N. (2011). Social effects of oxytocin in humans: context and person matter. Trends Cogn. Sci. 15, 301–309. 10.1016/j.tics.2011.05.002
    1. Bittman B. B., Berk L. S., Felten D. L., Westengard J. (2001). Composite effects of group drumming music therapy on modulation of neuroendocrine-immune parameters in normal subjects. Altern. Ther. Health Med. 7, 38.
    1. Bruya B. (2010). Effortless Attention: A New Perspective in the Cognitive Science of Attention and Action. Cambridge, MA: MIT Press.
    1. Carter C. S. (2014). Oxytocin pathways and the evolution of human behavior. Annu. Rev. Psychol. 65, 17–39. 10.1146/annurev-psych-010213-115110
    1. Carter C. S., Pournajafi-Nazarloo H., Kramer K. M., Ziegler T. E., White-Traut R., Bello D., et al. . (2007). Oxytocin: behavioral associations and potential as a salivary biomarker. Ann. N.Y. Acad. Sci. 1098, 312–322. 10.1196/annals.1384.006
    1. Chanda M. L., Levitin D. J. (2013). The neurochemistry of music. Trends Cogn. Neurosci. 17, 179–193. 10.1016/j.tics.2013.02.007
    1. Clift S., Morrison I. (2011). Group singing fosters mental health and wellbeing: findings from the East Kent “singing for health” network project. Ment. Health Soc. Inclusion 15, 88–97. 10.1108/20428301111140930
    1. Clift S., Nicol J., Raisbeck M., Whitmore C., Morrison I. (2010). Group Singing, Wellbeing and Health: A Systematic Mapping of Research Evidence. Kent: Sidney De Haan Research Centre for Arts and Health, Canterbury Christ Church University.
    1. Csikszentmihalyi M. (1975). Beyond Boredom and Anxiety. San Francisco, CA: Jossey-Bass Publishers.
    1. Csikszentmihalyi M. (1997). Finding flow: The Psychology of Engagement with Everyday Life. New York, NY: Basic Books.
    1. Csikszentmihalyi M., LeFevre J. (1989). Optimal experience in work and leisure. J. Pers. Soc. Psychol. 56, 815–822. 10.1037/0022-3514.56.5.815
    1. Dai L., Carter C. S., Ying J., Bellugi U., Pournajafi-Nazarloo H., Korenberg J. R. (2012). Oxytocin and vasopressin are dysregulated in Williams Syndrome, a genetic disorder affecting social behavior. PLoS One 7:e38513. 10.1371/journal.pone.0038513
    1. Diaz F. M. (2013). Mindfulness, attention, and flow during music listening: an empirical investigation. Psychol. Music 41, 42–58. 10.1177/0305735611415144
    1. Ditzen B., Schaer M., Gabriel B., Bodenmann G., Ehlert U., Heinrichs M., et al. . (2009). Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict. Biol. Psychiatry 65, 728–731. 10.1016/j.biopsych.2008.10.011
    1. Edison H. (Composer), Hendricks J. (Lyricist). (1958). Centerpiece. [arr. Greg Jasperse, 2015].
    1. Engeser S. (2012). Advances in Flow Research. New York, NY: Springer.
    1. Evers S., Suhr B. (2000). Changes of the neurotransmitter serotonin but not of hormones during short time music perception. Eur. Arch. Psychiatry Clin. Neurosci. 250, 144–147. 10.1007/s004060070031
    1. Fancourt D., Aufegger L., Williamon A. (2015). Low-stress and high-stress singing have contrasting effects on glucocorticoid response. Front. Psychol. 6:1242 10.3389/fpsyg.2015.01242
    1. Fancourt D., Ockelford A., Belai A. (2014). The psychoneuroimmunological effects of music: A systematic review and a new model. Brain Behav. Immun. 36, 15–26. 10.1016/j.bbi.2013.10.014
    1. Feldman R., Gordon I., Schneiderman I., Weisman O., Zagoory-Sharon O. (2010). Natural variations in maternal and paternal care are associated with systematic changes in oxytocin following parent–infant contact. Psychoneuroendocrinology 35, 1133–1141. 10.1016/j.psyneuen.2010.01.013
    1. Freeman W. (1998). A neurobiological role of music in social bonding, in The Origins of Music, eds Wallin N. L., Merker B., Brown S. (Cambridge, MA: MIT Press; ), 411–424.
    1. Fritz B. S., Avsec A. (2007). The experience of flow and subjective well-being of music students. Horiz. Psychol. 17, 5–17.
    1. Gerra G., Zaimovic A., Franchini D., Palladino M., Giucastro G., Reali N., et al. . (1998). Neuroendocrine responses of healthy volunteers totechno-music: relationships with personality traits and emotional state. Int. J. Psychophysiol. 28, 99–111.
    1. Gibbs D. M. (1986). Vasopressin and oxytocin: hypothalamic modulators of the stress response: a review. Psychoneuroendocrinology 11, 131–139. 10.1016/0306-4530(86)90048-X
    1. Grape C., Sandgren M., Hansson L. O., Ericson M., Theorell T. (2002). Does singing promote well-being?: An empirical study of professional and amateur singers during a singing lesson. Integr. Physiol. Behav. Sci. 38, 65–74. 10.1007/BF02734261
    1. Grossman A., Perry L., Schally A. V., Rees L., Kruseman A. N., Tomlin S., et al. (1982). New hypothalamic hormone, corticotropin-releasing factor, specifically stimulates the release of adrenocorticotropic hormone and cortisol in man. Lancet 319, 921–922.
    1. Hart E., Di Blasi Z. (2015). Combined flow in musical jam sessions: a pilot qualitative study. Psychol. Music 43, 275–290. 10.1177/0305735613502374
    1. Heinrichs M., von Dawans B., Domes G. (2009). Oxytocin, vasopressin, and human social behavior. Front Neuroendocrinol. 30, 548–557. 10.1016/j.yfrne.2009.05.005
    1. Herman J. P. (2012). Neural pathways of stress integration: relevance to alcohol abuse. Alcohol Res. 34, 441.
    1. Hytönen-Ng E. (2013). Experiencing “Flow” in Jazz Performance. Farnham: Ashgate.
    1. Jackson S. A., Eklund R. C. (2002). Assessing flow in physical activity: The flow state scale-2 and dispositional flow scale-2. J. Sport Exerc. Psychol. 24, 133–150.
    1. Jackson S. A., Eklund R. C., Martin A. J. (2010). The Flow Scales Instrument and Scoring Guide. Menlo Park, CA: Mind Garden Inc.
    1. Jackson S. A., Martin A. J., Eklund R. C. (2008). Long and short measures of flow: The construct validity of the FSS-2, DFS-2, and new brief counterparts. J. Sport Exerc. Psychol. 30, 561.
    1. Jackson S. A., Thomas P. R., Marsh H. W., Methurst C. J. (2001). Relationships between flow, self-concept, psychological skills, and performance. J. Appl. Sport Psychol. 13, 129–153. 10.1080/104132001753149865
    1. Kosfeld M., Heinrichs M., Zak P. J., Fischbacher U., Fehr E. (2005). Oxytocin increases trust in humans. Nature 435, 673–676. 10.1038/nature03701
    1. Kreutz G. (2014). Does singing facilitate social bonding? Music Med. 6, 51–60.
    1. Kreutz G., Bongard S., Rohrmann S., Hodapp V., Grebe D. (2004). Effects of choir singing or listening on secretory immunoglobulin A, cortisol, and emotional state. J. Behav. Med. 27, 623–635. 10.1007/s10865-004-0006-9
    1. LaGasse A. B. (2013). Pilot and feasibility studies: application in music therapy research. J. Music Ther. 50, 304–320. 10.1093/jmt/50.4.304
    1. Leslie J. S., Toni E. Z., Seth D. P. (2010). Social vocalizations can release oxytocin in humans. Proc. R. Soc. B Biol. Sci. 277, 2661–2666. 10.1098/rspb.2010.0567
    1. MacDonald R. A., Wilson G. B. (2014). Musical improvisation and health: a review. Psychol. Well Being 4, 1–18. 10.1186/s13612-014-0020-9
    1. MacDonald R., Byrne C., Carlton L. (2006). Creativity and flow in musical composition: an empirical investigation. Psychol. Music 34, 292–306. 10.1177/0305735606064838
    1. Martin W. L., Carter C. S. (2013). Oxytocin and vasopressin are sequestered in plasma, in 10th World Congress of Neurohypophyseal Hormones Abstracts (Bristol: ).
    1. Mauri A., Volpe A. (1994). Stress mediators in the amniotic compartment in relation to the degree of fetal distress. Fetal Diagn. Ther. 9, 300–305. 10.1159/000263952
    1. McCullough M. E., Churchland P. S., Mendez A. J. (2013). Problems with measuring peripheral oxytocin: can the data on oxytocin and human behavior be trusted? Neurosci. Biobehav. Rev. 37, 1485–1492. 10.1016/j.neubiorev.2013.04.018
    1. Mugford A. L. (2004). Flow in a Team Sport Setting: Does Cohesion Matter? Ph.D. dissertation, University of Kansas.
    1. Nilsson U. (2009). Soothing music can increase oxytocin levels during bed rest after open-heart surgery: a randomised control trial. J. Clin. Nurs. 18, 2153–2161. 10.1111/j.1365-2702.2008.02718.x
    1. Pitts S. E. (2004). Everybody wants to be Pavoratti: The experience of music for performers and audience at a gilbert and sullivan festival. J. R. Music. Assoc. 129, 143–160. 10.1093/jrma/129.1.143
    1. Rathunde K. (1997). Parent–Adolescent interaction and optimal experience. J. Youth Adolesc. 26, 669–689. 10.1023/A:1022344608624
    1. Rogers S. E. (2013). Researching musical improvisation: Questions and challenges. Psychomusicology 23, 269–272. 10.1037/pmu0000027
    1. Salanova M., Rodríguez-Sánchez A. M., Schaufeli W. B., Cifre E. (2014). Flowing together: A longitudinal study of collective efficacy and collective flow among workgroups. J. Psychol. 148, 435. 10.1080/00223980.2013.806290
    1. Sandman C. A., George J., McCanne T. R., Nolan J. D., Kaswan J., Kastinj A. J. (1977). MSH/ACTH 4-10 influences behavioral and physiological measures of attention 1. J. Clin. Endocrinol. Metab. 44, 884–891. 10.1210/jcem-44-5-884
    1. Sandman C. A., George J. M., Nolan J. D., Van Riezen H., Kastin A. J. (1975). Enhancement of attention in man with ACTH/MSH 4–10. Physiol. Behav. 15, 427–431. 10.1016/0031-9384(75)90254-1
    1. Sawyer R. K. (2006). Group creativity: musical performance and collaboration. Psychol. Music 34, 148–165. 10.1177/0305735606061850
    1. Takahashi T., Gribovskaja-Rupp I., Babygirija R. (2013). The Physiology of Love: Role of Oxytocin in Human Relationships, Stress Response, and Health. New York, NY: Nova Science Publishers Inc.
    1. Uchino B. N. (2006). Social support and health: a review of physiological processes potentially underlying links to disease outcomes. J. Behav. Med. 29, 377–387. 10.1007/s10865-006-9056-5
    1. Walker C. J. (2010). Experiencing flow: is doing it together better than doing it alone? J. Posit. Psychol. 5, 3–11. 10.1080/17439760903271116
    1. Weijnen J. A., Slangen J. L. (1970). Effects of ACTH-analogues on extinction of conditioned behavior. Prog. Brain Res. 32, 221. 10.1016/S0079-6123(08)61538-1
    1. Welch G. F., Himonides E., Saunders J., Papageorgi I., Sarazin M. (2014). Singing and social inclusion. Front. Psychol. 5:803. 10.3389/fpsyg.2014.00803
    1. Windle R. J., Kershaw Y. M., Shanks N., Wood S. A., Lightman S. L., Ingram C. D. (2004). Oxytocin attenuates stress-induced c-fos mRNA expression in specific forebrain regions associated with modulation of hypothalamo–pituitary–adrenal activity. J. Neurosci. 24, 2974–2982. 10.1523/JNEUROSCI.3432-03.2004
    1. Wrigley W. J., Emmerson S. B. (2013). The experience of the flow state in live music performance. Psychol. Music 41, 292–305. 10.1177/0305735611425903
    1. Yalow R. S., Glick S. M., Roth J., Berson S. A. (1964). Radioimmunoassay of human plasma ACTH. J. Clin. Endocrinol. Metab. 24, 1219–1225. 10.1210/jcem-24-11-1219

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