The effects of time-restricted eating and weight loss on bone metabolism and health: a 6-month randomized controlled trial

Maria Papageorgiou, Emmanuel Biver, Julie Mareschal, Nicholas Edward Phillips, Alexandra Hemmer, Emma Biolley, Nathalie Schwab, Emily N C Manoogian, Elena Gonzalez Rodriguez, Daniel Aeberli, Didier Hans, Caroline Pot, Satchidananda Panda, Nicolas Rodondi, Serge L Ferrari, Tinh-Hai Collet, Maria Papageorgiou, Emmanuel Biver, Julie Mareschal, Nicholas Edward Phillips, Alexandra Hemmer, Emma Biolley, Nathalie Schwab, Emily N C Manoogian, Elena Gonzalez Rodriguez, Daniel Aeberli, Didier Hans, Caroline Pot, Satchidananda Panda, Nicolas Rodondi, Serge L Ferrari, Tinh-Hai Collet

Abstract

Objective: This study explored the impact of time-restricted eating (TRE) versus standard dietary advice (SDA) on bone health.

Methods: Adults with ≥1 component of metabolic syndrome were randomized to TRE (ad libitum eating within 12 hours) or SDA (food pyramid brochure). Bone turnover markers and bone mineral content/density by dual energy x-ray absorptiometry were assessed at baseline and 6-month follow-up. Statistical analyses were performed in the total population and by weight loss response.

Results: In the total population (n = 42, 76% women, median age 47 years [IQR: 31-52]), there were no between-group differences (TRE vs. SDA) in any bone parameter. Among weight loss responders (≥0.6 kg weight loss), the bone resorption marker β-carboxyterminal telopeptide of type I collagen tended to decrease after TRE but increase after SDA (between-group differences p = 0.041), whereas changes in the bone formation marker procollagen type I N-propeptide did not differ between groups. Total body bone mineral content decreased after SDA (p = 0.028) but remained unchanged after TRE (p = 0.31) in weight loss responders (between-group differences p = 0.028). Among nonresponders (<0.6 kg weight loss), there were no between-group differences in bone outcomes.

Conclusions: TRE had no detrimental impact on bone health, whereas, when weight loss occurred, it was associated with some bone-sparing effects compared with SDA.

© 2022 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.

References

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