The Effect of Ondansetron on the Analgesic Efficacy of Tramadol in Patients Undergoing Laparoscopic Cholecystectomy

Sevgi Bilgen, Dilek Erdoğan Ari, Emel Özveri, Sevgi Bilgen, Dilek Erdoğan Ari, Emel Özveri

Abstract

Purpose: Investigating the effect of ondansetron on the efficacy of tramadol in patients undergoing laparoscopic cholecystectomy.

Methods: Sixty American Society of Anesthesiologists (ASA) I-II patients over the age of 18 who underwent laparoscopic cholecystectomy were included in this study. All patients were given 1 mg/kg tramadol intravenously (iv) during the intraoperative period. Patients were randomly assigned to receive either 4 mg ondansetron (Group O) or 2 mL saline (Group S). Postoperative tramadol consumption, pain score (NRS), intensity of nausea (NRS), presence of vomiting, consumption of rescue analgesics and antiemetics, and patient satisfaction were recorded.

Results: A total of 60 patients were enrolled in the study; five patients were excluded due to deviation from the protocol. Data from 55 patients (Group O: 28 patients, Group S: 27 patients) were evaluated in the study. No differences between the two groups were detected for postoperative consumption of tramadol, pain score (NRS), intensity of nausea (NRS), presence of vomiting, consumption of rescue analgesics and antiemetics, and patient satisfaction.

Conclusions: The results showed that coadministration of tramadol and ondansetron did not change tramadol consumption during the postoperative 24 hours after laparoscopic cholecystectomy. Clinical trial registration number is as follows: https://ichgcp.net/clinical-trials-registry/NCT04745273-01/31/2021.

Conflict of interest statement

The authors declare that there are no conflicts of interest.

Copyright © 2022 Sevgi Bilgen et al.

Figures

Figure 1
Figure 1
Consumption of tramadol (in milligrams) during the postoperative 24 hours showed no difference between groups. Group O, n = 28; Group S, n = 27.
Figure 2
Figure 2
The heart rate did not differ significantly between the groups, except for the first postoperative hour: 78.64/min in group O versus 72.74/min in Group S (p=0.020). Group O, n = 28; Group S, n = 27.
Figure 3
Figure 3
Pain score on numerical rating scale (NRS) (0–10) in the postoperative 24 hours. There was no difference between the two groups during the study period. Group O, n = 28; Group S, n = 27.
Figure 4
Figure 4
Nausea score on numerical rating scale (NRS) (0–10) in the postoperative 24 hours. There was no difference between the two groups during the study period. Group O, n = 28; Group S n = 27.

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