MYBIOTA: A birth cohort on maternal and infant microbiota and its impact on infant health in Malaysia

Shiang Yen Eow, Wan Ying Gan, Tiemin Jiang, Su Peng Loh, Ling Jun Lee, Yit Siew Chin, Leslie Thian Lung Than, Kang Nien How, Pui Ling Thong, Yanpin Liu, Junying Zhao, Lijun Chen, Shiang Yen Eow, Wan Ying Gan, Tiemin Jiang, Su Peng Loh, Ling Jun Lee, Yit Siew Chin, Leslie Thian Lung Than, Kang Nien How, Pui Ling Thong, Yanpin Liu, Junying Zhao, Lijun Chen

Abstract

Background: The microbiota plays a key role in early immunity maturation that affects infant health and is associated with the development of non-communicable diseases and allergies in later life.

Objective: The MYBIOTA is a prospective mother-infant cohort study in Malaysia aiming to determine the association between gut microbiota with infant health (temperament, gastrointestinal disorders, eczema, asthma, and developmental delays) in Selangor, Malaysia.

Methods: Pregnant mothers will be enrolled in their first trimester of pregnancy, and follow-ups will be done for infants during their first year of life. Maternal-infant biological samples (blood, feces, saliva, urine, and breast milk), anthropometric, dietary, and clinical information will be collected at different time points from early pregnancy to 12 months postpartum.

Discussion: This study could provide a better understanding of the colonization and development of the gut microbiome during early life and its impact on infant health.

Clinical trial registration: https://ichgcp.net/clinical-trials-registry/NCT04919265" title="See in ClinicalTrials.gov">NCT04919265.

Keywords: asthma; birth cohort study; developmental delays; eczema; gastrointestinal disorders; microbiota.

Conflict of interest statement

Authors TJ, YL, JZ, and LC were employed by Beijing Sanyuan Foods Co. Ltd. The funder had the following involvement with the study: involvement in study design, data analysis, decision to publish, or preparation of the manuscript. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Copyright © 2022 Eow, Gan, Jiang, Loh, Lee, Chin, Than, How, Thong, Liu, Zhao and Chen.

Figures

Figure 1
Figure 1
Data collection time points and sample collections of mothers and infants.

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