Diagnosis of Fatal Human Case of St. Louis Encephalitis Virus Infection by Metagenomic Sequencing, California, 2016
Charles Y Chiu, Lark L Coffey, Jamie Murkey, Kelly Symmes, Hannah A Sample, Michael R Wilson, Samia N Naccache, Shaun Arevalo, Sneha Somasekar, Scot Federman, Doug Stryke, Paul Vespa, Gary Schiller, Sharon Messenger, Romney Humphries, Steve Miller, Jeffrey D Klausner, Charles Y Chiu, Lark L Coffey, Jamie Murkey, Kelly Symmes, Hannah A Sample, Michael R Wilson, Samia N Naccache, Shaun Arevalo, Sneha Somasekar, Scot Federman, Doug Stryke, Paul Vespa, Gary Schiller, Sharon Messenger, Romney Humphries, Steve Miller, Jeffrey D Klausner
Abstract
We used unbiased metagenomic next-generation sequencing to diagnose a fatal case of meningoencephalitis caused by St. Louis encephalitis virus in a patient from California in September 2016. This case is associated with the recent 2015-2016 reemergence of this virus in the southwestern United States.
Keywords: California; SLEV; St. Louis encephalitis virus; United States; West Nile virus; Zika virus; arboviruses; flavivirus infections; mNGS; meningitis/encephalitis; metagenomic next-generation sequencing; mosquitoborne infections; outbreak surveillance; vector-borne infections; viruses; whole-genome viral sequencing.
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Source: PubMed