Long-term improvement of breast cancer survivors' quality of life by a 2-week group physical and educational intervention: 5-year update of the 'PACThe' trial

Fabrice Kwiatkowski, Marie-Ange Mouret-Reynier, Martine Duclos, François Bridon, Thierry Hanh, Isabelle Van Praagh-Doreau, Armelle Travade, Marie-Paule Vasson, Sylvie Jouvency, Christian Roques, Yves-Jean Bignon, Fabrice Kwiatkowski, Marie-Ange Mouret-Reynier, Martine Duclos, François Bridon, Thierry Hanh, Isabelle Van Praagh-Doreau, Armelle Travade, Marie-Paule Vasson, Sylvie Jouvency, Christian Roques, Yves-Jean Bignon

Abstract

Background: The advantages of adapted physical activity and nutritional education (APANE) on breast cancer prognosis and quality of life (QoL) are well known, but long-term results are lacking.

Methods: A randomised controlled trial testing a 2-week intervention in hydrothermal centres including APANE enrolled 251 patients post-chemotherapy. QoL and weight control were significantly improved at 12 months. A 5-year follow-up was performed to evaluate the persistence of improvements.

Results: QoL increase (SF36) was persistent: effect-size at 2, 3, 4 and 5 years equalled respectively 0.27 (-0.01; 0.56), 0.28 (-0.02; 0.58), 0.41 (0.02; 0.81) and 0.45 (0.11; 0.80). Weight control observed after intervention lasted 2 years: 2.7% decrease at 1 year (P=0.0085), 2.5% at 2 years (P=0.025); and respectively for waist -2.4% (-3.6; -1.1) (P=0.000014) and -1.3% (-2.5; -0.1) (P=0.0072).

Conclusions: A 2-week intervention in hydrothermal centres performed shortly after chemotherapy can durably improve breast cancer patients' QoL and reduce weight.

Conflict of interest statement

RC is involved in the AFRETH council. His role was to supervise the global study methodology/design and check for the trial quality. He did not interfere with the management of the trial, nor with statistical calculations and manuscript preparation.

Figures

Figure 1
Figure 1
Inclusion flowchart and data count at each time-point. Qol, quality of life; diet, nutritional+anthropometric data.
Figure 2
Figure 2
Evolution of SF36 quality of life scores (ranking from 0=worst to 100=best) according to allocation group (A) QoL global score (B) Mental and Physical sub-scores (error bars correspond to 95% confidence interval).
Figure 3
Figure 3
Weight and waist-girth variations by allocation group over 3 years (=% differences between measures at inclusion and those at each time points) Error bars correspond to 95% confidence interval).

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Source: PubMed

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