Ebola vaccine R&D: Filling the knowledge gaps

Abstract

With an emphasis on systems analyses, the VSV-EBOVAC project harnesses state-of-the-art technologies that illuminate mechanisms behind the observed immunogenicity and reactogenicity of the rVSV-ZEBOV vaccine and ensures that such information is shared among stakeholders.

Trial registration: ClinicalTrials.gov NCT02283099 NCT02287480 NCT02296983.

Copyright © 2015, American Association for the Advancement of Science.

Figures

Fig. 1. Project plan form and functions.

Shown in schematic form is the VSV-EBOVAC structure of the project plan. Blood samples and clinical data are obtained throughout the study, and clinical, immunological, and -omics data are integrated in order to identify molecular signatures associated with the rVSV-ZEBOV vaccine. The project is overseen by a management team consisting of the project coordinator, the scientific coordinator, and the work-package (WP) leaders. (Inset, right) The project is organized and carried out in four WPs. WP1 extends the clinical trials to 12 months and organizes sample distribution between partners.