A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS
Konstantin Schwarz, Satnam Singh, Satish Kumar Parasuraman, Maggie Bruce, Lee Shepstone, Martin Feelisch, Magdalena Minnion, Shakil Ahmad, John Horowitz, Dana K Dawson, Michael P Frenneaux, Konstantin Schwarz, Satnam Singh, Satish Kumar Parasuraman, Maggie Bruce, Lee Shepstone, Martin Feelisch, Magdalena Minnion, Shakil Ahmad, John Horowitz, Dana K Dawson, Michael P Frenneaux
Abstract
In an aging western population, a significant number of patients continue to suffer from angina once all revascularization and optimal medical treatment options are exhausted. Under experimental conditions, oral supplementation with inorganic nitrate was shown to exhibit a blood pressure-lowering effect, and has also been shown to promote angiogenesis, improve endothelial dysfunction and mitochondrial efficiency in skeletal muscle. It is unknown whether similar changes occur in cardiac muscle. In the current study, we investigate whether oral sodium nitrate treatment will improve myocardial ischemia in patients with stable angina.
Trial registration: ClinicalTrials.gov NCT02078921.
Keywords: angina; inorganic nitrate; randomized controlled trial.
Conflict of interest statement
Financial & competing interests disclosure The study is funded by the Medical Research Council. Edura CT number: 2012-000196-17. Trial Registration: ClinicalTrials.gov NCT02078921. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
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Source: PubMed