Burden of prematurity-associated recurrent wheezing: caregiver missed work in the D-Wheeze trial

Lauren Ledingham, Curtis Tatsuoka, Nori Minich, Kristie R Ross, Leigh Ann Kerns, Carol L Wagner, Mamta Fuloria, Sharon Groh-Wargo, Teresa Zimmerman, Anna Maria Hibbs, Lauren Ledingham, Curtis Tatsuoka, Nori Minich, Kristie R Ross, Leigh Ann Kerns, Carol L Wagner, Mamta Fuloria, Sharon Groh-Wargo, Teresa Zimmerman, Anna Maria Hibbs

Abstract

Objective: This study describes the burden of prematurity-associated wheezing in black infants with respect to caregiver missed work.

Study design: We analyzed data from the D-Wheeze trial (ClinicalTrials.gov identifier NCT01601847). Black infants between 28-0/7 to 36-6/7 weeks' gestational age at birth receiving <28 days of supplemental oxygen were enrolled. The primary outcome was missed work to care for the infant in the first year.

Results: 147/277 (53.1%) infants had caregivers who reported time off. In an adjusted model, vitamin D supplementation (OR 0.52 [95% CI 0.30-0.89]; P = 0.018), recurrent wheeze (OR 2.26 [95% CI, 1.15-4.44]; P = 0.018), and other children in the household <5 years old (OR 0.45 [95% CI 0.26-0.78]; P = 0.004) were significantly associated with caregiver missed work.

Conclusions: Black premature infants had a significant burden of caregiver missed work, emphasizing the impact of prematurity-associated wheezing.

Figures

Figure 1.
Figure 1.
Percentage of caregivers of infants within the sustained vitamin D supplementation cohort (represented by thin lines) compared to percentage of caregivers of infants within the diet-limited vitamin D supplementation cohort (represented by thick lines) who missed the indicated days of work in one year to care for their child.
Figure 2.
Figure 2.
Percentage of caregivers of infants within the recurrent wheeze cohort (represented by thin lines) compared to percentage of caregivers of infants within the no recurrent wheeze cohort (represented by thick lines) who missed the indicated days of work in one year to care for their child.

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Source: PubMed

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