Physiological Mechanisms of Weight Gain-Induced Steatosis in People With Obesity
Elisa Fabbrini, Courtney Tiemann Luecking, Latisha Love-Gregory, Adewole L Okunade, Mihoko Yoshino, Gemma Fraterrigo, Bruce W Patterson, Samuel Klein, Elisa Fabbrini, Courtney Tiemann Luecking, Latisha Love-Gregory, Adewole L Okunade, Mihoko Yoshino, Gemma Fraterrigo, Bruce W Patterson, Samuel Klein
Abstract
Weight gain is associated with an increase in intrahepatic triglycerides (IHTGs), and is the primary cause of nonalcoholic fatty liver disease in obese individuals. We combined imaging and stable isotope tracer techniques to evaluate the physiologic mechanisms of weight gain-induced steatosis in 27 obese people. Weight gain appeared to increase IHTG content by generating an imbalance between hepatic fatty acid availability and disposal, and resulted in increased hepatic de novo lipogenesis, decreased intrahepatic fatty acid oxidation, and inadequate increases in IHTG export via very low-density lipoprotein secretion. ClinicalTrials.gov ID NCT01184170.
Keywords: Fatty Acid Oxidation; Overweight; VLDL; apoB100.
Conflict of interest statement
Disclosures: The authors have no conflicts of interest to disclose
Copyright © 2016 AGA Institute. Published by Elsevier Inc. All rights reserved.
Figures
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4691551/bin/nihms723576f1.jpg)
Source: PubMed