Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C disease
Mark W Robinson, Dagmara McGuinness, Rachael Swann, Stephen Barclay, Peter R Mills, Arvind H Patel, John McLauchlan, Paul G Shiels, Mark W Robinson, Dagmara McGuinness, Rachael Swann, Stephen Barclay, Peter R Mills, Arvind H Patel, John McLauchlan, Paul G Shiels
Abstract
Chronic hepatitis C virus infection (C-HC) is associated with higher mortality arising from hepatic and extrahepatic disease. This may be due to accelerated biological aging; however, studies in C-HC have thus far been based solely on telomere length as a biomarker of aging (BoA). In this study, we have evaluated CDKN2 locus transcripts as alternative BoAs in C-HC. Our results suggest that C-HC induces non-cell-autonomous senescence and accelerates biological aging. The CDKN2 locus may provide a link between C-HC and increased susceptibility to age-associated diseases and provides novel biomarkers for assessing its impact on aging processes in man.
Keywords: CDKN2 locus; biological aging; chronic HCV infection; telomere length.
© 2013 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
Source: PubMed