Antibody Response and Disease Severity in Healthcare Worker MERS Survivors

Abeer N Alshukairi, Imran Khalid, Waleed A Ahmed, Ashraf M Dada, Daniyah T Bayumi, Laut S Malic, Sahar Althawadi, Kim Ignacio, Hanadi S Alsalmi, Hail M Al-Abdely, Ghassan Y Wali, Ismael A Qushmaq, Basem M Alraddadi, Stanley Perlman, Abeer N Alshukairi, Imran Khalid, Waleed A Ahmed, Ashraf M Dada, Daniyah T Bayumi, Laut S Malic, Sahar Althawadi, Kim Ignacio, Hanadi S Alsalmi, Hail M Al-Abdely, Ghassan Y Wali, Ismael A Qushmaq, Basem M Alraddadi, Stanley Perlman

Abstract

We studied antibody response in 9 healthcare workers in Jeddah, Saudi Arabia, who survived Middle East respiratory syndrome, by using serial ELISA and indirect immunofluorescence assay testing. Among patients who had experienced severe pneumonia, antibody was detected for >18 months after infection. Antibody longevity was more variable in patients who had experienced milder disease.

Keywords: ELISA; IFA; Jeddah; MERS-CoV; Middle East respiratory syndrome coronavirus; Saudi Arabia; antibody; healthcare workers; immune response; indirect immunofluorescence assay; viruses.

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Source: PubMed

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