Impact of continuous positive airway pressure treatment on left atrial volume and function in patients with obstructive sleep apnoea assessed by real-time three-dimensional echocardiography

W Oliveira, O Campos, F Cintra, L Matos, M L C Vieira, B Rollim, L Fujita, S Tufik, D Poyares, W Oliveira, O Campos, F Cintra, L Matos, M L C Vieira, B Rollim, L Fujita, S Tufik, D Poyares

Abstract

Background: Obstructive sleep apnoea (OSA) has been reported as a predictor of left ventricle (LV) diastolic dysfunction and left atrium (LA) remodelling. The aim of this study is to evaluate the impact of OSA treatment with a continuous positive airway pressure device (CPAP) on the LA volume and function, as well as on the LV diastolic function.

Methods: In total, 56 OSA patients were studied. All patients underwent real-time three-dimensional (RT3DE) and two-dimensional echocardiogram with tissue Doppler evaluation in order to estimate LA volumes, function and LV diastolic performance. A total of 30 patients with an apnoea-hypopnoea index greater than 20 were randomly selected to receive sham CPAP (n = 15) or effective CPAP (n = 15) for 24 weeks. They underwent echo examination on three different occasions: at baseline, after 12 weeks and 24 weeks of CPAP or sham CPAP.

Results: In the effective CPAP group we observed the following changes from the baseline to the 24-week echo evaluation: (a) a reduction in the E/E' ratio (10.3 (1.9) to 7.9 (1.3), p = 0.03); (b) an increase in the LA passive emptying fraction (28.8% (11.9%) to 46.8% (9.3%), p = 0.01); and (c) a reduction in the LA active emptying fraction (42.7% (11.5%) to 25.7 (15.7), p<0.01). In the sham group, there were no changes from the baseline to the 24-week echo. We found a positive correlation between 24 week/baseline LA active emptying volume and 24 week/baseline E/E' ratios (r = 0.40, p<0.05) and a negative correlation between 24 week/baseline LA passive emptying volume and 24 week/baseline E/E' ratios (r = -0.53, p<0.05). No significant changes were found on LA total emptying fraction.

Conclusion: CPAP improved LV diastolic function and LA passive emptying, but not LA structural variables in OSA patients.

Trial registration number: NCT00768807.

Conflict of interest statement

Competing interests: None.

Figures

Figure 1
Figure 1
Study design. AHI, apnoea-hypopnoea index; OSA, obstructive sleep apnoea; CPAP, continuous positive airway pressure device.
Figure 2
Figure 2
Left atrial (LA) function and left ventricular diastolic performance throughout 24 weeks of sham or effective continuous positive airway pressure (CPAP) treatment.
Figure 3
Figure 3
(A) Correlation between 24-week/baseline left atrium (LA) active emptying volume and 24-week/baseline E/E′ ratios. (B) Correlation between 24-week/baseline left atrium (LA) passive emptying volume and 24-week/baseline E/E′ ratios.

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