Effects of a Mindfulness-Based Intervention on Self-Compassion and Psychological Health Among Young Adults With a History of Childhood Maltreatment

Diane Joss, Alaptagin Khan, Sara W Lazar, Martin H Teicher, Diane Joss, Alaptagin Khan, Sara W Lazar, Martin H Teicher

Abstract

Background: Individuals who were maltreated during childhood are faced with increased risks for developing various psychological symptoms that are particularly resistant to traditional treatments. This pilot study investigated the effects of a mindfulness based behavioral intervention for young adults with a childhood maltreatment history.

Methods: This study looked at self-report psychological questionnaires from 20 subjects (5 males) before and after a mindfulness-based behavioral intervention, compared to 18 subjects (6 males) in the waiting list control group (age range 22-29); all subjects experienced mild-to-moderate childhood maltreatment. We analyzed changes in stress, anxiety, depression, mindfulness and self-compassion related to the intervention with linear mixed effects models; we also analyzed the relationships among questionnaire score changes with partial correlation analyses and mediation analysis.

Results: Linear mixed effects model analyses revealed significant group by time interaction on stress (p < 0.01), anxiety (p < 0.05), and self-compassion (p < 0.01), with the mindfulness group having significant reduction in stress and anxiety (p < 0.01), and significant increase in mindfulness (p < 0.05) and self-compassion (p < 0.001). Partial correlation analyses showed that among all subjects from both groups, changes in mindfulness positively correlated with changes in self-compassion (r = 0.578, p = 0.001), which negatively correlated with changes in depression (r = -0.374, p = 0.05) and anxiety (r = -0.395, p < 0.05). Changes in self-compassion mediated, in part, the relationship between changes in mindfulness and changes in anxiety (average causal mediation effect = -4.721, p < 0.05). We observed a dose-dependent effect of the treatment, i.e., the number of intervention sessions attended were negatively correlated with changes in stress (r = -0.674, p < 0.01), anxiety (r = -0.580, p < 0.01), and depression (r = -0.544, p < 0.05), after controlling for the individual differences in childhood maltreatment severity.

Conclusion: Our results suggest that, to some extent, the mindfulness-based intervention can be helpful for improving self-compassion and psychological health among young adults with a childhood maltreatment history.

Clinical trial registration: www.ClinicalTrials.gov, identifier NCT02447744.

Keywords: anxiety; childhood maltreatment; depression; mindfulness; self-compassion; stress.

Copyright © 2019 Joss, Khan, Lazar and Teicher.

Figures

FIGURE 1
FIGURE 1
Flow chart of subject enrolment and retention.
FIGURE 2
FIGURE 2
Significant group by time interaction with scores of STAI-t (A), PSS (B), and SCS (C). In all panels, red triangles with dashed red lines represent the control group while blue circles with solid blue lines represent the mindfulness group; error bars are standard errors.
FIGURE 3
FIGURE 3
Positive correlation between changes in mindfulness and self-compassion. Subjects with more increase in mindfulness (measured by the Mindful Attention Awareness Scale) tend to have more increase in self-compassion (measured by the Self-Compassion Scale).
FIGURE 4
FIGURE 4
The amount of changes in depression and anxiety severity is negatively correlated with the amount of changes in self-compassion (A) and positively correlated with the amount of changes in stress (B).
FIGURE 5
FIGURE 5
Mediation effects of self-compassion (ΔSCS: the amount of changes in scores of Self-Compassion Scale) between the changes in mindfulness (ΔMAAS: the amount of changes in scores of Mindful Attention Awareness Scale) and changes in anxiety (A) (ΔSTAI-t: the amount of changes in scores of State-Trait Anxiety Inventory-Trait subscale) and stress (B) (ΔPSS: the amount of changes in scores of Perceived Stress Scale).
FIGURE 6
FIGURE 6
Intervention compliance and treatment effects: subjects who attended more intervention sessions had more reduction in depression, anxiety and stress (A), while subjects who practiced more at home had more increase in self-compassion (B).
FIGURE 7
FIGURE 7
Childhood maltreatment negatively impacts treatment effects. Subjects with more severe maltreatment (A), or more severe physical maltreatment as measured by Childhood Trauma Questionnaire (CTQ) or MACE (B), or more severe parental verbal maltreatment (C), tend to have less reduction in anxiety symptoms.

References

    1. Andrews B. (1998). “Shame and childhood abuse,” in Shame: Interpersonal Behavior, Psychopathology, and Culture, eds Gilbert P., Andrews B. (New York, NY: Oxford University Press; ), 176–190.
    1. Baer R. A., Carmody J., Hunsinger M. (2012a). Weekly change in mindfulness and perceived stress in a mindfulness-based stress reduction program. J. Clin. Psychol. 68 755–765. 10.1002/jclp.21865
    1. Baer R. A., Lykins E. L., Peters J. R. (2012b). Mindfulness and self-compassion as predictors of psychological wellbeing in long-term meditators and matched nonmeditators. J. Posit. Psychol. 7 230–238. 10.1080/17439760.2012.674548
    1. Baer R. A., Smith G. T., Hopkins J., Krietemeyer J., Toney L. (2006). Using self-report assessment methods to explore facets of mindfulness. Assessment 13 27–45. 10.1177/1073191105283504
    1. Banks K., Newman E., Saleem J. (2015). An overview of the research on mindfulness-based interventions for treating symptoms of posttraumatic stress disorder: a systematic review. J. Clin. Psychol. 71 935–963. 10.1002/jclp.22200
    1. Beck A. T., Steer R. A., Brown G. K. (1996). Beck depression inventory-II. San Antonio 78 490–498.
    1. Bernet C. Z., Stein M. B. (1999). Relationship of childhood maltreatment to the onset and course of major depression in adulthood. Depress. Anxiety 9 169–174. 10.1002/(sici)1520-6394(1999)9:4<169::aid-da4>;2-u
    1. Birnie K., Speca M., Carlson L. E. (2010). Exploring self-compassion and empathy in the context of mindfulness-based stress reduction (MBSR). Stress Health 26 359–371. 10.1002/smi.1305
    1. Boyd J. E., Lanius R. A., McKinnon M. C. (2018). Mindfulness-based treatments for posttraumatic stress disorder: a review of the treatment literature and neurobiological evidence. J. Psychiatry Neurosci. 43 7–25. 10.1503/jpn.170021
    1. Brown K. W., Ryan R. M. (2003). The benefits of being present: mindfulness and its role in psychological well-being. J. Pers. Soc. Psychol. 84 822–848. 10.1037/0022-3514.84.4.822
    1. Bungert M., Liebke L., Thome J., Haeussler K., Bohus M., Lis S. (2015). Rejection sensitivity and symptom severity in patients with borderline personality disorder: effects of childhood maltreatment and self-esteem. Borderline Personal. Disord. Emot. Dysregul. 2:4. 10.1186/s40479-015-0025-x
    1. Carmody J., Baer R. A. (2008). Relationships between mindfulness practice and levels of mindfulness, medical and psychological symptoms and well-being in a mindfulness-based stress reduction program. J. Behav. Med. 31 23–33. 10.1007/s10865-007-9130-7
    1. Chin B., Slutsky J., Raye J., Creswell J. D. (2019). Mindfulness training reduces stress at work: a randomized controlled trial. Mindfulness 10 627–638. 10.1007/s12671-018-1022-1020
    1. Cohen S., Kamarck T., Mermelstein R. (1994). “Perceived stress scale,” in Measuring Stress: A Guide for Health and Social Scientists, ed. Kessler R. C. (Oxford: Oxford University Press; ), 235–283.
    1. Dorahy M. J., Clearwater K. (2012). Shame and guilt in men exposed to childhood sexual abuse: a qualitative investigation. J. Child Sex Abuse 21 155–175. 10.1080/10538712.2012.659803
    1. Dunkley D. M., Masheb R. M., Grilo C. M. (2010). Childhood maltreatment, depressive symptoms, and body dissatisfaction in patients with binge eating disorder: the mediating role of self-criticism. In. J. Eat. Disord. 43 274–281. 10.1002/eat.20796
    1. Evans S., Ferrando S., Findler M., Stowell C., Smart C., Haglin D. (2008). Mindfulness-based cognitive therapy for generalized anxiety disorder. J. Anxiety Disord. 22 716–721. 10.1016/j.janxdis.2007.07.005
    1. Felitti V. J., Anda R. F., Nordenberg D., Williamson D. F., Spitz A. M., Edwards V., et al. (1998). Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults: the adverse childhood experiences (ACE) study. Am. J. Prev. Med. 14 245–258. 10.1016/s0749-3797(98)00017-8
    1. Follette V., Palm K. M., Pearson A. N. (2006). Mindfulness and trauma: implications for treatment. J. Ration Emot. Cogn. Behav. Ther. 24 45–61. 10.1007/s10942-006-0025-2
    1. Gard T., Brach N., Hölzel B. K., Noggle J. J., Conboy L. A., Lazar S. W. (2012). Effects of a yoga-based intervention for young adults on quality of life and perceived stress: the potential mediating roles of mindfulness and self-compassion. J. Posit. Psychol. 7 165–175. 10.1080/17439760.2012.667144
    1. Goldin P. R., Gross J. J. (2010). Effects of mindfulness-based stress reduction (MBSR) on emotion regulation in social anxiety disorder. Emotion 10 83–91. 10.1037/a0018441
    1. Greenberg J., Datta T., Shapero B. G., Sevinc G., Mischoulon D., Lazar S. W. (2018). Compassionate hearts protect against wandering minds: self-compassion moderates the effect of mind-wandering on depression. Spiritual. Clin. Pract. 5 155–169. 10.1037/scp0000168
    1. Harkness K. L., Bagby R. M., Kennedy S. H. (2012). Childhood maltreatment and differential treatment response and recurrence in adult major depressive disorder. J. Consult Clin. Psychol. 80 342–353. 10.1037/a0027665
    1. Harris P. A., Taylor R., Thielke R., Payne J., Gonzalez N., Conde J. G. (2009). Research electronic data capture (REDCap)—A metadata-driven methodology and workflow process for providing translational research informatics support. J. Biomed. Inform. 42 377–381. 10.1016/j.jbi.2008.08.010
    1. Herman J. L., Perry C., Van der Kolk B. A. (1989). Childhood trauma in borderline personality disorder. Am. J. Psychiatry 146 490–495. 10.1176/ajp.146.4.490
    1. Hoglund C. L., Nicholas K. B. (1995). Shame, guilt, and anger in college students exposed to abusive family environments. J. Fam. Violence 10 141–157. 10.1007/bf02110597
    1. Johnson J. G., Cohen P., Brown J., Smailes E. M., Bernstein D. P. (1999). Childhood maltreatment increases risk for personality disorders during early adulthood. Arch. Gen. Psychiatry 56 600–606.
    1. Kabat-Zinn J. (1990). Full Catastrophe Living: Using the Wisdom of Your Body and Mind in Everyday Life. New York, NY: Delacorte.
    1. Keller M. B., Lavori P. W., Friedman B., Nielsen E., Endicott J., McDonald-Scott P., et al. (1987). The longitudinal interval follow-up evaluation: a comprehensive method for assessing outcome in prospective longitudinal studies. Arch. Gen. Psychiatry 44 540–548. 10.1001/archpsyc.1987.01800180050009
    1. Khan A., McCormack H. C., Bolger E. A., McGreenery C. E., Vitaliano G., Polcari A., et al. (2015). Childhood maltreatment, depression, and suicidal ideation: critical importance of parental and peer emotional abuse during developmental sensitive periods in males and females. Front. Psychiatry 6:42. 10.3389/fpsyt.2015.00042
    1. King A. P., Erickson T. M., Giardino N. D., Favorite T., Rauch S. A., Robinson E., et al. (2013). A pilot study of group mindfulness-based cognitive therapy (MBCT) for combat veterans with posttraumatic stress disorder (PTSD). Depress. Anxiety 30 638–645. 10.1002/da.22104
    1. Kuyken W., Warren F. C., Taylor R. S., Whalley B., Crane C., Bondolfi G., et al. (2016). Efficacy of mindfulness-based cognitive therapy in prevention of depressive relapse: an individual patient data meta-analysis from randomized trials. JAMA Psychiatry 73 565–574. 10.1001/jamapsychiatry.2016.0076
    1. Lang A. J., Strauss J. L., Bomyea J., Bormann J. E., Hickman S. D., Good R. C., et al. (2012). The theoretical and empirical basis for meditation as an intervention for PTSD. Behav. Modif. 36 759–786. 10.1177/0145445512441200
    1. Lindstrom M. J., Bates D. M. (1988). Newton-Raphson and EM algorithms for linear mixed-effects models for repeated-measures data. J. Am. Stat. Assoc. 83 1014–1022. 10.1080/01621459.1988.10478693
    1. Linehan M. M., Schmidt H., Dimeff L. A., Craft J. C., Kanter J., Comtois K. A. (1999). Dialectical behavior therapy for patients with borderline personality disorder and drug-dependence. Am. J. Addict. 8 279–292. 10.1080/105504999305686
    1. Ma S. H., Teasdale J. D. (2004). Mindfulness-based cognitive therapy for depression: replication and exploration of differential relapse prevention effects. J. Consult. Clin. Psychol. 72 31–40. 10.1037/0022-006x.72.1.31
    1. McEvoy P. M. (2019). Metacognitive therapy for anxiety disorders: a review of recent advances and future research directions. Curr. Psychiatry Rep. 21:29. 10.1007/s11920-019-1014-3
    1. McLaughlin K. A., Borkovec T. D., Sibrava N. J. (2007). The effects of worry and rumination on affect states and cognitive activity. Behav. Ther. 38 23–38. 10.1016/j.beth.2006.03.003
    1. Moran L. R., Kaplan C., Aguirre B., Galen G., Stewart J. G., Tarlow N., et al. (2018). Treatment effects following residential dialectical behavior therapy for adolescents with borderline personality disorder. Evid. Based Pract. Child Adolesc. Ment. Health 3 117–128. 10.1080/23794925.2018.1476075
    1. Nanni V., Uher R., Danese A. (2012). Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: a meta-analysis. Am. J. Psychiatry 169 141–151. 10.1176/appi.ajp.2011.11020335
    1. Neff K. D. (2003). The development and validation of a scale to measure self-compassion. Self Identity 2 223–250. 10.1080/15298860309027
    1. Neff K. D. (2016). The self-compassion scale is a valid and theoretically coherent measure of self-compassion. Mindfulness 7 264–274. 10.1007/s12671-015-0479-3
    1. Neff K. D., Germer C. K. (2013). A pilot study and randomized controlled trial of the mindful self-compassion program. J. Clin. Psychol. 69 28–44. 10.1002/jclp.21923
    1. Pietrek C., Elbert T., Weierstall R., Müller O., Rockstroh B. (2013). Childhood adversities in relation to psychiatric disorders. Psychiatry Res. 206 103–110. 10.1016/j.psychres.2012.11.003
    1. Rodrigues M. F., Campos C., Pelucio L., Barreto I., Machado S., Appolinario J. C., et al. (2019). Patients’ comprehension of mindfulness-based cognitive behavioral therapy in an outpatient clinic for resistant depression: a cross-sectional study. Front. Psychol. 10:271. 10.3389/fpsyg.2019.00271
    1. Roemer L., Orsillo S. M. (2002). Expanding our conceptualization of and treatment for generalized anxiety disorder: integrating mindfulness/acceptance-based approaches with existing cognitive-behavioral models. Clin. Psychol. 9 54–68. 10.1093/clipsy.9.1.54
    1. Santorelli S. F., Kabat-Zinn J., Blacker M., Meleo-Meyer F., Koerbel L. (2017). “Mindfulness-based stress reduction (MBSR) authorized curriculum guide,” in Center for Mindfulness in Medicine, Health Care, and Society (CFM), (Worcester, MA: University of Massachusetts Medical School; ).
    1. Shamseddeen W., Asarnow J. R., Clarke G., Vitiello B., Wagner K. D., Birmaher B., et al. (2011). Impact of physical and sexual abuse on treatment response in the treatment of resistant depression in adolescent study (TORDIA). J. Am. Acad. Child Adolesc. Psychiatry 50 293–301. 10.1016/j.jaac.2010.11.019
    1. Shapiro S. L., Astin J. A., Bishop S. R., Cordova M. (2005). Mindfulness-based stress reduction for health care professionals: results from a randomized trial. Int. J. Stress Manag. 12 164–176. 10.1037/1072-5245.12.2.164
    1. Shapiro S. L., Brown K. W., Biegel G. M. (2007). Teaching self-care to caregivers: effects of mindfulness-based stress reduction on the mental health of therapists in training. Train. Educ. Prof. Psychol. 1 105–115. 10.1037/1931-3918.1.2.105
    1. Soler J., Valdepérez A., Feliu-Soler A., Pascual J. C., Portella M. J., Martín-Blanco A., et al. (2012). Effects of the dialectical behavioral therapy-mindfulness module on attention in patients with borderline personality disorder. Behav. Res. Therapy 50 150–157. 10.1016/j.brat.2011.12.002
    1. Spielberger C. D., Sydeman S. J. (1994). “State-Trait anxiety inventory and state-trait anger expression inventory,” in The Use of Psychological Testing for Treatment Planning and Outcome Assessment, ed. Maruish M. (Hillsdale, NJ: Lawrence Erlbaum Associates; ).
    1. Stein J. A., Leslie M. B., Nyamathi A. (2002). Relative contributions of parent substance use and childhood maltreatment to chronic homelessness, depression, and substance abuse problems among homeless women: mediating roles of self-esteem and abuse in adulthood. Child Abuse Neglect 26 1011–1027. 10.1016/s0145-2134(02)00382-4
    1. Stuewig J., McCloskey L. A. (2005). The relation of child maltreatment to shame and guilt among adolescents: psychological routes to depression and delinquency. Child Maltreat. 10 324–336. 10.1177/1077559505279308
    1. Tanaka M., Wekerle C., Schmuck M. L., Paglia-Boak A., Team M. R. (2011). The linkages among childhood maltreatment, adolescent mental health, and self-compassion in child welfare adolescents. Child Abuse Neglect 35 887–898. 10.1016/j.chiabu.2011.07.003
    1. Teicher M. H., Anderson C. M., Polcari A. (2012). Childhood maltreatment is associated with reduced volume in the hippocampal subfields CA3, dentate gyrus, and subiculum. Proc. Natl. Acad. Sci. U.S.A. 109 E563–E572. 10.1073/pnas.1115396109
    1. Teicher M. H., Parigger A. (2015). The ‘maltreatment and abuse chronology of exposure’(MACE) scale for the retrospective assessment of abuse and neglect during development. PLoS One 10:e0117423. 10.1371/journal.pone.0117423
    1. Tingley D., Yamamoto T., Hirose K., Keele L., Imai K. (2014). Mediation: R package for causal mediation analysis. J. Stat. Softw. 59 10.18637/jss.v059.i05
    1. Tunnard C., Rane L. J., Wooderson S. C., Markopoulou K., Poon L., Fekadu A., et al. (2014). The impact of childhood adversity on suicidality and clinical course in treatment-resistant depression. J. Affect. Disord. 152 122–130. 10.1016/j.jad.2013.06.037
    1. Van Dam N. T., Sheppard S. C., Forsyth J. P., Earleywine M. (2011). Self-compassion is a better predictor than mindfulness of symptom severity and quality of life in mixed anxiety and depression. J. Anxiety Disord. 25 123–130. 10.1016/j.janxdis.2010.08.011
    1. Verheul R., Van Den Bosch L. M., Koeter M. W., De Ridder M. A., Stijnen T., Van Den Brink W. (2003). Dialectical behaviour therapy for women with borderline personality disorder: 12-month, randomised clinical trial in the Netherlands. Br. J. Psychiatry 182 135–140. 10.1192/bjp.182.2.135
    1. Vettese L. C., Dyer C. E., Li W. L., Wekerle C. (2011). Does self-compassion mitigate the association between childhood maltreatment and later emotion regulation difficulties? a preliminary investigation. Int. J. Ment. Health Addict. 9 480–491. 10.1007/s11469-011-9340-7
    1. Williams J. M., Crane C., Barnhofer T., Brennan K., Duggan D. S., Fennell M. J., et al. (2014). Mindfulness-based cognitive therapy for preventing relapse in recurrent depression: a randomized dismantling trial. J. Consult Clin. Psychol. 82 275–286. 10.1037/a0035036
    1. World Health Organization (2016). Child Maltreatment [Online] Available: (accessed July 16, 2019).

Source: PubMed

3
Subskrybuj