Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007

Robert S Lanciotti, Olga L Kosoy, Janeen J Laven, Jason O Velez, Amy J Lambert, Alison J Johnson, Stephanie M Stanfield, Mark R Duffy, Robert S Lanciotti, Olga L Kosoy, Janeen J Laven, Jason O Velez, Amy J Lambert, Alison J Johnson, Stephanie M Stanfield, Mark R Duffy

Abstract

Zika virus (ZIKV) is a mosquito-borne flavivirus first isolated in Uganda from a sentinel monkey in 1947. Mosquito and sentinel animal surveillance studies have demonstrated that ZIKV is endemic to Africa and Southeast Asia, yet reported human cases are rare, with <10 cases reported in the literature. In June 2007, an epidemic of fever and rash associated with ZIKV was detected in Yap State, Federated States of Micronesia. We report the genetic and serologic properties of the ZIKV associated with this epidemic.

Figures

Figure 1
Figure 1
Phylogenetic tree constructed from nucleic acid data from flavivirus nonstructural protein 5 region by the neighbor-joining algorithm in MEGA (www.megasoftware.net). Numbers to the left of the nodes are bootstrap percentages (2,000 replications) for clades. Clade numbers correspond to clades identified by Kuno et al. (16). Enc, encephalitis; ME, meningoencephalitis.
Figure 2
Figure 2
Alignment of nucleotide and amino acid sequences adjacent to the envelope (ENV)–154 glycosylation site of Zika virus strains. Dashes indicate deletions. EC, epidemic consensus.

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