Immunohistological characterization of lymphoid cell populations in the early human placental bed
J N Bulmer, C A Sunderland, J N Bulmer, C A Sunderland
Abstract
The distribution of leukocytes in first trimester human decidual tissue has been studied by using a panel of monoclonal antibodies in an indirect immunoperoxidase technique on acetone-fixed cryostat sections. The results indicate that bone marrow-derived cells are abundant in the placental bed and a proportion of these are HLA-DR positive. However, a major leukocyte population in the decidua of early pregnancy is of cells which carry the E-rosette receptor but which do not express peripheral pan-T cell antigens nor HLA-DR. The distribution of these cells suggests that they are endometrial granulocytes. A similar large number of cells express OKT 10, a marker of immature or activated cells. The presence of this unusual T lineage cell raises the possibility that a form of lymphocyte processing is occurring in the decidua in early pregnancy, perhaps in response to foetal antigens presented on trophoblast.
References
- Int Arch Allergy Appl Immunol. 1971;40(1):137-52
- J Reprod Fertil. 1975 Mar;42(3):431-8
- J Anat. 1977 Jul;123(Pt 3):687-96
- Cell Tissue Res. 1977 Nov 23;184(4):517-27
- Eur J Immunol. 1979 Mar;9(3):205-10
- Science. 1979 Oct 19;206(4416):347-9
- Eur J Immunol. 1980 Oct;10(10):737-44
- J Immunol. 1981 Apr;126(4):1608-13
- Cell. 1981 Mar;23(3):771-80
- J Immunol. 1981 Jun;126(6):2117-22
- Proc Natl Acad Sci U S A. 1981 Mar;78(3):1791-5
- J Exp Med. 1981 Feb 1;153(2):310-23
- J Exp Med. 1981 Apr 1;153(4):753-65
- J Immunol. 1981 Sep;127(3):1024-9
- Eur J Immunol. 1981 Oct;11(10):849-51
- J Reprod Immunol. 1981 Dec;3(6):323-31
- Eur J Immunol. 1982 Jan;12(1):81-6
- J Immunol. 1983 Jan;130(1):145-52
- Clin Haematol. 1982 Oct;11(3):531-59
- Clin Haematol. 1982 Oct;11(3):697-709
- J Reprod Immunol. 1982 Dec;4(6):355-64
- Transplantation. 1983 Apr;35(4):385-90
- Immunology. 1983 May;49(1):103-12
- Am J Reprod Immunol. 1983 Mar;3(2):65-71
- Cell Tissue Res. 1983;233(3):647-56
- J Reprod Immunol. 1983 Nov;5(6):383-7
- Am J Obstet Gynecol. 1984 Jan 1;148(1):19-26
Source: PubMed