Acute Intoxication following Dimethyltryptamine Ingestion

Matthew H Bilhimer, Rachel F Schult, Kristan V Higgs, Timothy J Wiegand, Rachel M Gorodetsky, Nicole M Acquisto, Matthew H Bilhimer, Rachel F Schult, Kristan V Higgs, Timothy J Wiegand, Rachel M Gorodetsky, Nicole M Acquisto

Abstract

Ayahuasca is a hallucinogenic tea that is most commonly comprised of the vine Banisteriopsis caapi alone or in combination with other plants such as Psychotria viridis. This concoction results in an orally active form of dimethyltryptamine (DMT), a hallucinogenic amine. Despite use in South America as a medicinal agent and component in religious ceremonies, interest in its recreational use and spiritual effects has led to increased use in the United States. We describe a unique case following ingestion of ayahuasca tea in a patient with history of schizophrenia resulting in personal injury and property damage. A review of ayahuasca toxicity and evaluation of serious adverse effects is also presented.

References

    1. Araújo A. M., Carvalho F., Bastos M. D. L., Guedes de Pinho P., Carvalho M. The hallucinogenic world of tryptamines: an updated review. Archives of Toxicology. 2015;89(8):1151–1173. doi: 10.1007/s00204-015-1513-x.
    1. Winstock A. R., Kaar S., Borschmann R. Dimethyltryptamine (DMT): Prevalence, user characteristics and abuse liability in a large global sample. Journal of Psychopharmacology. 2014;28(1):49–54. doi: 10.1177/0269881113513852.
    1. Heise C. W., Brooks D. E. Ayahuasca Exposure: Descriptive Analysis of Calls to US Poison Control Centers from 2005 to 2015. Journal of Medical Toxicology. 2016
    1. Harris R., Gurel L. A study of ayahuasca use in North America. Journal of Psychoactive Drugs. 2012;44(3):209–215. doi: 10.1080/02791072.2012.703100.
    1. Domínguez-Clavé E., Soler J., Elices M., et al. Ayahuasca: Pharmacology, neuroscience and therapeutic potential. Brain Research Bulletin. 2016;126:89–101. doi: 10.1016/j.brainresbull.2016.03.002.
    1. Cunningham N. Hallucinogenic plants of abuse. EMA - Emergency Medicine Australasia. 2008;20(2):167–174. doi: 10.1111/j.1742-6723.2008.01070.x.
    1. Riba J., Rodríguez-Fornells A., Urbano G., et al. Subjective effects and tolerability of the South American psychoactive beverage Ayahuasca in healthy volunteers. Psychopharmacology. 2001;154(1):85–95. doi: 10.1007/s002130000606.
    1. Riba J., Barbanoj M. J. Bringing ayahuasca to the clinical research laboratory. Journal of Psychoactive Drugs. 2005;37(2):219–230. doi: 10.1080/02791072.2005.10399804.
    1. Warren R. J. Fatal nicotine intoxication resulting from the ingestion of, ayahuasca. Journal of Analytical Toxicology. 2004:28–287.
    1. Sklerov J., Levine B., Moore K. A., King T., Fowler D. A fatal intoxication following the ingestion of 5-methoxy-N,N- dimethyltryptamine in an ayahuasca preparation. Journal of Analytical Toxicology. 2005;29(8):838–841. doi: 10.1093/jat/29.8.838.
    1. Guimarães dos Santos R. Safety and Side Effects of Ayahuasca in Humans-An Overview Focusing on Developmental Toxicology. Journal of Psychoactive Drugs. 2013;45(1):68–78. doi: 10.1080/02791072.2013.763564.
    1. Lima F. A. S., Tófoli L. F. An epidemiological surveillance system by the UDV: mental health recommendations concerning the religious use of hoasca. In: Labate B. C., Jungaberle H., editors. The Internationalization of Ayahuasca. Zurich/Berlin: Lit Verlag; 2011. pp. 185–199.
    1. Callaway J. C., Grob C. S. Ayahuasca preparations and serotonin reuptake inhibitors: A potential combination for severe adverse interactions. Journal of Psychoactive Drugs. 1998;30(4):367–369. doi: 10.1080/02791072.1998.10399712.
    1. Joint Appendix. O Centro Espirita Beneficiente Uniao Do Vegetal et al. v. John Ashcroft, no. CV02-2323, on Writ of Certiorari to the US Court of Appeals for the 10th Circuit, New Mexico, 2002.
    1. Gable R. S. Risk assessment of ritual use of oral dimethyltryptamine (DMT) and harmala alkaloids. Addiction. 2007;102(1):24–34. doi: 10.1111/j.1360-0443.2006.01652.x.
    1. Szmulewicz A. G., Valerio M. P., Smith J. M. Switch to mania after ayahuasca consumption in a man with bipolar disorder: a case report. International Journal of Bipolar Disorders. 2015;3(1) doi: 10.1186/s40345-014-0020-y.
    1. dos Santos R. G., Osório F. L., Crippa J. A. S., Hallak J. E. C. Antidepressive and anxiolytic effects of ayahuasca: A systematic literature review of animal and human studies. Revista Brasileira de Psiquiatria. 2016;38(1):65–72. doi: 10.1590/1516-4446-2015-1701.
    1. dos Santos R. G., Osório F. L., Crippa J. A., Riba J., Zuardi A. W., Hallak J. E. Antidepressive, anxiolytic, and antiaddictive effects of ayahuasca, psilocybin and lysergic acid diethylamide (LSD): a systematic review of clinical trials published in the last 25 years. Therapeutic Advances in Psychopharmacology. 2016;6(3):193–213. doi: 10.1177/2045125316638008.
    1. Taj M. Canadian man kills Brit in psychedelic ceremony in Peru's Amazon. Reuters UK, 2015.

Source: PubMed

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