Effects of periarticular injection on analgesic effects and NSAID use in total knee arthroplasty and total hip arthroplasty

Wen-Rui Ban, Ery-Ang Zhang, Lei-Feng Lv, Xiao-Qian Dang, Chen Zhang, Wen-Rui Ban, Ery-Ang Zhang, Lei-Feng Lv, Xiao-Qian Dang, Chen Zhang

Abstract

Objectives: This study examined periarticular multimodal drug injection and the use of nonsteroidal anti-inflammatory drugs for an early analgesic effect after total knee arthroplasty and total hip arthroplasty. Patient satisfaction and benefits from the treatment were also assessed.

Methods: A total of 110 patients who were scheduled to undergo total knee arthroplasty and 86 patients who were scheduled to undergo total hip arthroplasty were divided into two groups, the study group and the control group. The study group received a periarticular multimodal drug injection during surgery. The control group received an equal volume of normal saline. All patients received an analgesia pump and a moderate dose of nonsteroidal anti-inflammatory drugs. Resting and motion Numeric Rating Scale scores, the Western Ontario and McMaster Universities Arthritis Index, knee or hip joint range of motion, length of postoperative hospital stay, patient satisfaction, total nonsteroidal anti-inflammatory drug consumption and side effects were recorded.

Results: Both study groups exhibited significant improvement in pain Numeric Rating Scale scores during rest and exercise several days after the surgery. The range of joint motion was greater in the study group, and the length of postoperative hospital stay was shorter than that in the control group. Patients in the study group consumed fewer nonsteroidal anti-inflammatory drugs and reported greater satisfaction with surgery.

Conclusion: Intraoperative periarticular multimodal drug injection significantly relieved pain after surgery and reduced nonsteroidal anti-inflammatory drug consumption. These patient had a better postoperative experience, including satisfaction and rehabilitation.

Conflict of interest statement

No potential conflict of interest was reported.

Figures

Figure 1
Figure 1
Subject inclusion decision tree.
Figure 2
Figure 2
The NRS scores with activity. *The average NRS score with activity in the TKA study group was lower than that in the control group at 12 h, 24 h, 48 h, and 72 h; the average NRS score in the THA group was lower than that in the control group at 12 h, 24 h, 48 h, 72 h, 4 d and 6 d.
Figure 3
Figure 3
*The NRS scores at rest. The average score in the TKA study group was lower than that in the control group at 12 h, 24 h, and 48 h, whereas the average score in the THA study group was lower than that in the control group at 12 h, 24 h, 48 h, 72 h, 4 d and 5 d.
Figure 4
Figure 4
Range of motion.
Figure 5
Figure 5
NSAID consumption.
Figure 6
Figure 6
WOMAC scores after the operation.

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