[1.6% peppermint oil solution as intestinal spasmolytic in retrograde endoscopic cholangiopancreatography]
N Solà-Bonada, A M de Andrés-Lázaro, M Roca-Massa, J M Bordas-Alsina, C Codina-Jané, J Ribas-Sala, N Solà-Bonada, A M de Andrés-Lázaro, M Roca-Massa, J M Bordas-Alsina, C Codina-Jané, J Ribas-Sala
Abstract
Objectives: Intestinal peristalsis can impede explorations and interventions using retrograde endoscopic cholangiopancreatography. Systemic spasmolytics are frequently employed to reduce this phenomenon, in spite of the adverse anti-cholinergic effects they are associated with. We proposed a formula using 1.6% peppermint oil solution with local use in order to avoid these adverse side effects.
Method: We formulated a preparation of 1.6% peppermint oil solution in accordance with the medical literature. The effectiveness of the formula was evaluated in a semi-qualitative manner according to the reduction in peristalsis.
Results: We tested two different emulgents, and polysorbate provided the best results. The pilot study carried out with 8 patients demonstrated its effectiveness and safety in reducing intestinal peristalsis.
Conclusions: 1.6% peppermint oil solution constitutes an effective and safe alternative to the use of systemic spasmolytics. More studies are needed with a larger sample size in order to establish its usefulness in normal clinical practice.
Copyright © 2011 SEFH. Published by Elsevier Espana. All rights reserved.
Source: PubMed