Effect of general anesthesia combined with epidural anesthesia on circulation and stress response of patients undergoing hysterectomy

Abstract

Objective: To investigate the effect of general anesthesia combined with epidural anesthesia on circulation and stress response of patients undergoing hysterectomy.

Methods: A total of 97 patients undergoing hysterectomy in our hospital from December 2017 to December 2019 were recruited as the research participants, of whom 44 patients (general anesthesia group) received general anesthesia and 53 patients (joint group) received general anesthesia combined with epidural anesthesia during operation. The hemodynamic indexes, anesthetic effect, anesthetic recovery effect, cognitive function, and stress substance levels of the two groups were compared.

Results: Compared with the general anesthesia group, the SBP and HR of the patients in the joint group were more stable, and the anesthesia effect and recovery effect in the joint group were better. The MMSE score of the joint group at 6 h and 12 h after anesthesia was significantly higher than that of the general anesthesia group (P < 0.001). There was no significant difference in the levels of adrenaline and norepinephrine between the two groups before operation (P > 0.05). The levels of stress substances in the two groups increased at 30 min after operation (P < 0.001), and those in the joint group were significantly lower than those in the control group (P < 0.001).

Conclusion: Compared with general anesthesia, general anesthesia combined with epidural anesthesia produces better anesthetic effect in hysterectomy, has less influence on patients' circulatory response and can reduce stress response.

Keywords: General anesthesia; circulatory function; epidural anesthesia; hysterectomy; stress reaction.

Conflict of interest statement

None.

AJTR Copyright © 2021.

Figures

Figure 1

Comparison of hemodynamic indexes. A. SBP changes in two groups. SBP levels in the joint group at T2 and T3 were significantly lower than those in the general anesthesia group. B. Changes of HR in the two groups. HR in the joint group was significantly higher than that in the general anesthesia group at T1 and T2. * indicates a statistical difference compared with T0; # indicates a statistical difference compared with another group.

Figure 2

Comparison of stress substance levels. A. There was no significant difference in adrenalin levels between the two groups before operation. The adrenalin levels in the two groups 30 min after operation were higher than those before operation, and the adrenalin levels in the joint group were significantly lower than those in the control group. B. There was no significant difference in norepinephrine levels between the two groups before operation. The levels of norepinephrine in the two groups 30 min after operation were higher than those before operation, and the levels of norepinephrine in the joint group were significantly lower than those in the control group. *** indicates P