Epigenetic regulation in antiviral innate immunity

Xiao Wang, Huawei Xia, Shengde Liu, Lili Cao, Fuping You, Xiao Wang, Huawei Xia, Shengde Liu, Lili Cao, Fuping You

Abstract

Emerging life-threatening viruses have posed great challenges to public health. It is now increasingly clear that epigenetics plays a role in shaping host-virus interactions and there is a great need for a more thorough understanding of these intricate interactions through the epigenetic lens, which may represent potential therapeutic opportunities in the clinic. In this review, we highlight the current understanding of the roles of key epigenetic regulators - chromatin remodeling and histone modification - in modulating chromatin openness during host defense against virus. We also discuss how the RNA modification m6A (N6-methyladenosine) affects fundamental aspects of host-virus interactions. We conclude with future directions for uncovering more detailed functions that epigenetic regulation exerts on both host cells and viruses during infection.

Keywords: Antiviral innate immunity; Chromatin remodeling; Epigenetics; Histone modification; m6A.

© 2021 Wiley-VCH GmbH.

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