The importance of nutrition in pregnancy and lactation: lifelong consequences

Nicole E Marshall, Barbara Abrams, Linda A Barbour, Patrick Catalano, Parul Christian, Jacob E Friedman, William W Hay Jr, Teri L Hernandez, Nancy F Krebs, Emily Oken, Jonathan Q Purnell, James M Roberts, Hora Soltani, Jacqueline Wallace, Kent L Thornburg, Nicole E Marshall, Barbara Abrams, Linda A Barbour, Patrick Catalano, Parul Christian, Jacob E Friedman, William W Hay Jr, Teri L Hernandez, Nancy F Krebs, Emily Oken, Jonathan Q Purnell, James M Roberts, Hora Soltani, Jacqueline Wallace, Kent L Thornburg

Abstract

Most women in the United States do not meet the recommendations for healthful nutrition and weight before and during pregnancy. Women and providers often ask what a healthy diet for a pregnant woman should look like. The message should be "eat better, not more." This can be achieved by basing diet on a variety of nutrient-dense, whole foods, including fruits, vegetables, legumes, whole grains, healthy fats with omega-3 fatty acids that include nuts and seeds, and fish, in place of poorer quality highly processed foods. Such a diet embodies nutritional density and is less likely to be accompanied by excessive energy intake than the standard American diet consisting of increased intakes of processed foods, fatty red meat, and sweetened foods and beverages. Women who report "prudent" or "health-conscious" eating patterns before and/or during pregnancy may have fewer pregnancy complications and adverse child health outcomes. Comprehensive nutritional supplementation (multiple micronutrients plus balanced protein energy) among women with inadequate nutrition has been associated with improved birth outcomes, including decreased rates of low birthweight. A diet that severely restricts any macronutrient class should be avoided, specifically the ketogenic diet that lacks carbohydrates, the Paleo diet because of dairy restriction, and any diet characterized by excess saturated fats. User-friendly tools to facilitate a quick evaluation of dietary patterns with clear guidance on how to address dietary inadequacies and embedded support from trained healthcare providers are urgently needed. Recent evidence has shown that although excessive gestational weight gain predicts adverse perinatal outcomes among women with normal weight, the degree of prepregnancy obesity predicts adverse perinatal outcomes to a greater degree than gestational weight gain among women with obesity. Furthermore, low body mass index and insufficient gestational weight gain are associated with poor perinatal outcomes. Observational data have shown that first-trimester gain is the strongest predictor of adverse outcomes. Interventions beginning in early pregnancy or preconception are needed to prevent downstream complications for mothers and their children. For neonates, human milk provides personalized nutrition and is associated with short- and long-term health benefits for infants and mothers. Eating a healthy diet is a way for lactating mothers to support optimal health for themselves and their infants.

Keywords: adolescent pregnancy; developmental origins of disease; fetal and neonatal nutrition; gestational diabetes mellitus; lactation; macronutrients; maternal nutrition; micronutrients; nutritional requirements; pregnancy; vitamin supplementation.

Conflict of interest statement

The authors report no conflict of interest.

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Figures

FIGURE 1. Dietary patterns and maternal and…
FIGURE 1. Dietary patterns and maternal and birth outcomes: systematic review results
GDM, gestational diabetes mellitus; HDP, hypertensive disorders of pregnancy; HHS, Department of Health and Human Services; NESR, Nutrition Evidence Systematic Review; USDA, US Department of Agriculture.
FIGURE 2
FIGURE 2
Fish choice guide for pregnancy
FIGURE 3
FIGURE 3
My pregnancy plate

References

    1. Barker DJ. The developmental origins of adult disease. J Am Coll Nutr 2004;23:588S–95S.
    1. World Health Organization. WHO antenatal care recommendations for a positive pregnancy experience. Nutritional interventions update: multiple micronutrient supplements during pregnancy. Geneva, Switzerland: World Health Organization; 2020.
    1. National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Food and Nutrition Board In: Harrison M, ed. Nutrition during pregnancy and lactation: exploring new evidence: proceedings of a workshop. Washington, DC: National Academies Press; 2020.
    1. Stoody EE, Spahn JM, Casavale KO. The Pregnancy and Birth to 24 Months Project: a series of systematic reviews on diet and health. Am J Clin Nutr 2019;109:685–697S.
    1. Raghavan R, Dreibelbis C, Kingshipp BL, et al. Dietary patterns before and during pregnancy and maternal outcomes: a systematic review. Am J Clin Nutr 2019;109:705–728S.
    1. Raghavan R, Dreibelbis C, Kingshipp BL, et al. Dietary patterns before and during pregnancy and birth outcomes: a systematic review. Am J Clin Nutr 2019;109:729–756S.
    1. Güngör D, Nadaud P, LaPergola CC, et al. Infant milk-feeding practices and diabetes outcomes in offspring: a systematic review. Am J Clin Nutr 2019;109:817–837S.
    1. US Department of Agriculture. US Department of Health and Human Services. Dietary Guidelines for Americans, 2020–2025. 9th Edition. Dietary Guidelines for Americans. 2020. Available at: . Accessed November 11, 2021.
    1. Dietary Guidelines Advisory Committee. Scientific report of the 2020 Dietary Guidelines Advisory Committee: advisory report to the Secretary of Agriculture and the Secretary of Health and Human Services. Dietary Guidelines for Americans. 2020. Available at: . Accessed November 11, 2021.
    1. Koletzko B, Godfrey KM, Poston L, et al. Nutrition during pregnancy, lactation and early childhood and its implications for maternal and long-term child health: the early nutrition project recommendations. Ann Nutr Metab 2019;74:93–106.
    1. Deputy NP, Sharma AJ, Kim SY, Hinkle SN. Prevalence and characteristics associated with gestational weight gain adequacy. Obstet Gynecol 2015;125:773–81.
    1. Robbins CL, Zapata LB, Farr SL, et al. Core state preconception health indicators - pregnancy risk assessment monitoring system and behavioral risk factor surveillance system, 2009. MMWR Surveill Summ 2014;63:1–62.
    1. Shin D, Lee KW, Song WO. Pre-pregnancy weight status is associated with diet quality and nutritional biomarkers during pregnancy. Nutrients 2016;8:162.
    1. Bodnar LM, Simhan HN, Parker CB, et al. Racial or ethnic and socioeconomic inequalities in adherence to national dietary guidance in a large cohort of US pregnant women. J Acad Nutr Diet 2017;117:867–77.e3.
    1. Carmichael SL, Ma C, Feldkamp ML, Shaw GM; National Birth Defects Prevention Study. Comparing usual dietary intakes among subgroups of mothers in the year before pregnancy. Public Health Rep 2019;134:155–63.
    1. Bailey RL, Pac SG, Fulgoni VL 3rd, Reidy KC, Catalano PM. Estimation of total usual dietary intakes of pregnant women in the United States. JAMA Netw Open 2019;2:e195967.
    1. Rai D, Bird JK, McBurney Ml, Chapman-Novakofski KM. Nutritional status as assessed by nutrient intakes and biomarkers among women of childbearing age—is the burden of nutrient inadequacies growing in America? Public Health Nutr 2015;18:1658–69.
    1. Almond D, Currie J. Killing me softly: the fetal origins hypothesis. J Econ Perspect 2011;25:153–72.
    1. Hytten F Nutritional requirements in pregnancy. What happens if they are not met? Midwifery 1990;6:140–5.
    1. Abrams B, Altman SL, Pickett KE. Pregnancy weight gain: still controversial. Am J Clin Nutr 2000;71:1233–1241S.
    1. Stephenson J, Heslehurst N, Hall J, et al. Before the beginning: nutrition and lifestyle in the preconception period and its importance for future health. Lancet 2018;391:1830–41.
    1. Fleming TP, Watkins AJ, Velazquez MA, et al. Origins of lifetime health around the time of conception: causes and consequences. Lancet 2018;391:1842–52.
    1. Godfrey KM, Matthews N, Glazier J, Jackson A, Wilman C, Sibley CP. Neutral amino acid uptake by the microvillous plasma membrane of the human placenta is inversely related to fetal size at birth in normal pregnancy. J Clin Endocrinol Metab 1998;83:3320–6.
    1. Institute of Medicine (US) and National Research Council (US) Committee to Reexamine IOM Pregnancy Weight Guidelines In: Rasmussen KM, Yaktine AL, eds. Weight gain during pregnancy: reexamining the guidelines. Washington (DC): National Academies Press (US); 2009.
    1. Kominiarek MA, Peaceman AM. Gestational weight gain. Am J Obstet Gynecol 2017;217:642–51.
    1. Hanson MA, Bardsley A, De-Regil LM, et al. The International Federation of Gynecology and Obstetrics (FIGO) recommendations on adolescent, preconception, and maternal nutrition: “Think Nutrition First.” Int J Gynaecol Obstet 2015;131:S213–53.
    1. Ramakrishnan U, Grant F, Goldenberg T, Zongrone A, Martorell R. Effect of women’s nutrition before and during early pregnancy on maternal and infant outcomes: a systematic review. Paediatr Perinat Epidemiol 2012;26:285–301.
    1. Lindsay KL, Buss C, Wadhwa PD, Entringer S. The interplay between nutrition and stress in pregnancy: implications for fetal programming of brain development. Biol Psychiatry 2019;85:135–49.
    1. Borge TC, Aase H, Brantsæter AL, Biele G. The importance of maternal diet quality during pregnancy on cognitive and behavioural outcomes in children: a systematic review and meta-analysis. BMJ Open 2017;7:e016777.
    1. De-Regil LM, Peña-Rosas JP, Fernández-Gaxiola AC, Rayco-Solon P. Effects and safety of periconceptional oral folate supplementation for preventing birth defects. Cochrane Database Syst Rev 2015:CD007950.
    1. Keats EC, Haider BA, Tam E, Bhutta ZA. Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database Syst Rev 2019;3:CD004905.
    1. Fall CHD, Kumaran K. Metabolic programming in early life in humans. Philos Trans R Soc Lond B Biol Sci 2019;374:20180123.
    1. Aris IM, Fleisch AF, Oken E. Developmental origins of disease: emerging prenatal risk factors and future disease risk. Curr Epidemiol Rep 2018;5:293–302.
    1. Lassance L, Haghiac M, Leahy P, et al. Identification of early transcriptome signatures in placenta exposed to insulin and obesity. Am J Obstet Gynecol 2015;212:647.e1–11.
    1. Calkins K, Devaskar SU. Fetal origins of adult disease. Curr Probl Pediatr Adolesc Health Care 2011;41:158–76.
    1. Stanner SA, Bulmer K, Andrès C, et al. Does malnutrition in utero determine diabetes and coronary heart disease in adulthood? Results from the Leningrad siege study, a cross sectional study. BMJ 1997;315:1342–8.
    1. World health Organization. Report of the Commission on Ending Childhood Obesity: implementation plan: executive summary. World Health Organization. 2017. Available at: . Accessed November 11, 2021.
    1. Hambidge KM, Bann CM, McClure EM, et al. Maternal characteristics affect fetal growth response in the women first preconception nutrition trial. Nutrients 2019;11:2534.
    1. Hambidge KM, Westcott JE, Garcés A, et al. A multicountry randomized controlled trial of comprehensive maternal nutrition supplementation initiated before conception: the Women First trial. Am J Clin Nutr 2019;109:457–69.
    1. ACOG Practice Bulletin No 156: obesity in pregnancy. Obstet Gynecol 2015;126:e112–26.
    1. Flegal KM, Kruszon-Moran D, Carroll MD, Fryar CD, Ogden CL. Trends in obesity among adults in the United States, 2005 to 2014. JAMA 2016;315:2284–91.
    1. van Elten TM, Karsten MDA, Geelen A, et al. Preconception lifestyle intervention reduces long term energy intake in women with obesity and infertility: a randomised controlled trial. Int J Behav Nutr Phys Act 2019;16:3.
    1. van Elten TM, Karsten MDA, Geelen A, et al. Effects of a preconception lifestyle intervention in obese infertile women on diet and physical activity; a secondary analysis of a randomized controlled trial. PLoS One 2018;13:e0206888.
    1. Opray N, Grivell RM, Deussen AR, Dodd JM. Directed preconception health programs and interventions for improving pregnancy outcomes for women who are overweight or obese. Cochrane Database Syst Rev 2015;7:CD010932.
    1. Catalano PM, Tyzbir ED, Allen SR, McBean JH, McAuliffe TL. Evaluation of fetal growth by estimation of neonatal body composition. Obstet Gynecol 1992;79:46–50.
    1. WHO recommendations on antenatal care for a positive pregnancy experience. Geneva, Switzerland: World Health Organization; 2016.
    1. Blencowe H, Krasevec J, de Onis M, et al. National, regional, and worldwide estimates of low birthweight in 2015, with trends from 2000: a systematic analysis. Lancet Glob Health 2019;7:e849–60.
    1. Salam RA, Das JK, Ali A, Lassi ZS, Bhutta ZA. Maternal undernutrition and intra-uterine growth restriction. Expert Rev Obstet Gynecol 2013;8:559–67.
    1. Bergmann RL, Bergmann KE, Dudenhausen JW. Undernutrition and growth restriction in pregnancy. Nestle Nutr Workshop Ser Pediatr Program 2008;61:103–21.
    1. Thorn SR, Rozance PJ, Brown LD, Hay WW Jr. The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetes. Semin Reprod Med 2011;29:225–36.
    1. Thorn SR, Brown LD, Rozance PJ, Hay WW Jr, Friedman JE. Increased hepatic glucose production in fetal sheep with intra-uterine growth restriction is not suppressed by insulin. Diabetes 2013;62:65–73.
    1. Gluckman PD, Hanson MA, Buklijas T, Low FM, Beedle AS. Epigenetic mechanisms that underpin metabolic and cardiovascular diseases. Nat Rev Endocrinol 2009;5:401–8.
    1. Ross MG, Beall MH. Adult sequelae of intrauterine growth restriction. Semin Perinatol 2008;32:213–8.
    1. Morrison JL, Regnault TR. Nutrition in pregnancy: optimising maternal diet and fetal adaptations to altered nutrient supply. Nutrients 2016;8:342.
    1. American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins—Obstetrics and the Society for Maternal-Fetal Medicine. ACOG Practice Bulletin No. 204: fetal growth restriction. Obstet Gynecol 2019;133:e97–109.
    1. Carr DJ, Wallace JM, Aitken RP, et al. Uteroplacental adenovirus vascular endothelial growth factor gene therapy increases fetal growth velocity in growth-restricted sheep pregnancies. Hum Gene Ther 2014;25:375–84.
    1. Potdar RD, Sahariah SA, Gandhi M, et al. Improving women’s diet quality preconceptionally and during gestation: effects on birth weight and prevalence of low birth weight—a randomized controlled efficacy trial in India (Mumbai Maternal Nutrition Project). Am J Clin Nutr 2014;100:1257–68.
    1. Embleton ND, Skeath T. Catch-up growth and metabolic and cognitive outcomes in adolescents born preterm. Nestlé Nutr Inst Workshop Ser 2015;81:61–71.
    1. Embleton ND, Korada M, Wood CL, Pearce MS, Swamy R, Cheetham TD. Catch-up growth and metabolic outcomes in adolescents born preterm. Arch Dis Child 2016;101:1026–31.
    1. Heude B, Thiébaugeorges O, Goua V, et al. Pre-pregnancy body mass index and weight gain during pregnancy: relations with gestational diabetes and hypertension, and birth outcomes. Matern Child Health J 2012;16:355–63.
    1. Barbour LA, Hernandez TL. Maternal lipids and fetal overgrowth: making fat from fat. Clin Ther 2018;40:1638–47.
    1. Hernandez TL, Van Pelt RE, Anderson MA, et al. A higher-complex carbohydrate diet in gestational diabetes mellitus achieves glucose targets and lowers postprandial lipids: a randomized crossover study. Diabetes Care 2014;37:1254–62.
    1. Barbour LA, Farabi SS, Friedman JE, et al. Postprandial triglycerides predict newborn fat more strongly than glucose in women with obesity in early pregnancy. Obesity (Silver Spring) 2018;26:1347–56.
    1. Kulkarni SR, Kumaran K, Rao SR, et al. Maternal lipids are as important as glucose for fetal growth: findings from the Pune Maternal Nutrition Study. Diabetes Care 2013;36:2706–13.
    1. Adank MC, Benschop L, Kors AW, et al. Maternal lipid profile in early pregnancy is associated with foetal growth and the risk of a child born large-for-gestational age: a population-based prospective cohort study : maternal lipid profile in early pregnancy and foetal growth. BMC Med 2020;18:276.
    1. Herrera E, Desoye G. Maternal and fetal lipid metabolism under normal and gestational diabetic conditions. Horm Mol Biol Clin Investig 2016;26:109–27.
    1. Kim SR, Kubo T, Kuroda Y, et al. Comparative metabolome analysis of cultured fetal and adult hepatocytes in humans. J Toxicol Sci 2014;39:717–23.
    1. Elsakr JM, Dunn JC, Tennant K, et al. Maternal western-style diet affects offspring islet composition and function in a non-human primate model of maternal over-nutrition. Mol Metab 2019;25:73–82.
    1. Carver TD, Anderson SM, Aldoretta PA, Esler AL, Hay WW Jr. Glucose suppression of insulin secretion in chronically hyperglycemic fetal sheep. Pediatr Res 1995;38:754–62.
    1. Jing YH, Song YF, Yao YM, Yin J, Wang DG, Gao LP. Retardation of fetal dendritic development induced by gestational hyperglycemia is associated with brain insulin/IGF-I signals. Int J Dev Neurosci 2014;37:15–20.
    1. Bytoft B, Knorr S, Vlachova Z, et al. Long-term cognitive implications of intrauterine hyperglycemia in adolescent offspring of women with type 1 diabetes (the EPICOM Study). Diabetes Care 2016;39:1356–63.
    1. ∅yen N, Diaz LJ, Leirgul E, et al. Prepregnancy diabetes and offspring risk of congenital heart disease: a nationwide cohort study. Circulation 2016;133:2243–53.
    1. Mackin ST, Nelson SM, Wild SH, et al. Factors associated with stillbirth in women with diabetes. Diabetologia 2019;62:1938–47.
    1. Browne K, Park BY, Goetzinger KR, Caughey AB, Yao R. The joint effects of obesity and pregestational diabetes on the risk of still-birth. J Matern Fetal Neonatal Med 2021;34:332–8.
    1. Anderson EL, Howe LD, Jones HE, Higgins JP, Lawlor DA, Fraser A. The prevalence of non-alcoholic fatty liver disease in children and adolescents: a systematic review and meta-analysis. PLoS One 2015;10:e0140908.
    1. Wesolowski SR, Kasmi KC, Jonscher KR, Friedman JE. Developmental origins of NAFLD: a womb with a clue. Nat Rev Gastroenterol Hepatol 2017;14:81–96.
    1. Brumbaugh DE, Tearse P, Cree-Green M, et al. Intrahepatic fat is increased in the neonatal offspring of obese women with gestational diabetes. J Pediatr 2013;162:930–6.e1.
    1. Hernandez TL, Farabi SS, Hirsch NM, et al. Maternal triglycerides in gestational diabetes are strongly associated with increased newborn hepatic fat independent of subcutaneous fat. Diabetes 2019;68.
    1. Newton KP, Feldman HS, Chambers CD, et al. Low and high birth weights are risk factors for nonalcoholic fatty liver disease in children. J Pediatr 2017;187:141–6.e1.
    1. Conde-Agudelo A, Belizán JM, Lammers C. Maternal-perinatal morbidity and mortality associated with adolescent pregnancy in Latin America: cross-sectional study. Am J Obstet Gynecol 2005;192:342–9.
    1. Ganchimeg T, Ota E, Morisaki N, et al. Pregnancy and childbirth outcomes among adolescent mothers: a World Health Organization multicountry study. BJOG 2014;121 (Suppl1):40–8.
    1. Neal S, Channon AA, Chintsanya J. The impact of young maternal age at birth on neonatal mortality: evidence from 45 low and middle income countries. PLoS One 2018;13:e0195731.
    1. Salihu HM, Sharma PP, Ekundayo OJ, et al. Childhood pregnancy (10–14 years old) and risk of stillbirth in singletons and twins. J Pediatr 2006;148:522–6.
    1. Marvin-Dowle K, Soltani H. A comparison of neonatal outcomes between adolescent and adult mothers in developed countries: a systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol X 2020;6:100109.
    1. Frisancho AR, Matos J, Leonard WR, Yaroch LA. Developmental and nutritional determinants of pregnancy outcome among teenagers. Am J Phys Anthropol 1985;66:247–61.
    1. Scholl TO, Hediger ML, Schall JI. Maternal growth and fetal growth: pregnancy course and outcome in the Camden Study. Ann N Y Acad Sci 1997;817:292–301.
    1. Luther J, Aitken R, Milne J, et al. Maternal and fetal growth, body composition, endocrinology, and metabolic status in undernourished adolescent sheep. Biol Reprod 2007;77:343–50.
    1. Wallace JM. Competition for nutrients in pregnant adolescents: consequences for maternal, conceptus and offspring endocrine systems. J Endocrinol 2019;242:T1–19.
    1. Wallace JM, Aitken RP, Cheyne MA. Nutrient partitioning and fetal growth in rapidly growing adolescent ewes. J Reprod Fertil 1996;107:183–90.
    1. Wallace JM, Aitken RP, Milne JS, Hay WW Jr. Nutritionally mediated placental growth restriction in the growing adolescent: consequences for the fetus. Biol Reprod 2004;71:1055–62.
    1. Wallace JM, Luther JS, Milne JS, et al. Nutritional modulation of adolescent pregnancy outcome – a review. Placenta 2006;27(SupplA):S61–8.
    1. Adam CL, Williams PA, Milne JS, Aitken RP, Wallace JM. Orexigenic gene expression in late gestation ovine foetal hypothalamus is sensitive to maternal undernutrition and realimentation. J Neuroendocrinol 2015;27:765–71.
    1. Wallace JM, Milne JS, Aitken RP, Horgan GW, Adam CL. Ovine prenatal growth restriction impacts glucose metabolism and body composition throughout life in both sexes. Reproduction 2018;156:103–19.
    1. Marvin-Dowle K, Kilner K, Burley V, Soltani H. Differences in dietary pattern by maternal age in the Born in Bradford cohort: a comparative analysis. PLoS One 2018;13:e0208879.
    1. Das JK, Salam RA, Thornburg KL, et al. Nutrition in adolescents: physiology, metabolism, and nutritional needs. Ann N Y Acad Sci 2017;1393:21–33.
    1. Krebs N, Bagby S, Bhutta ZA, et al. International summit on the nutrition of adolescent girls and young women: consensus statement. Ann N Y Acad Sci 2017;1400:3–7.
    1. Goldstein RF, Abell SK, Ranasinha S, et al. Association of gestational weight gain with maternal and infant outcomes: a systematic review and meta-analysis. JAMA 2017;317:2207–25.
    1. da Silva Lopes K, Ota E, Shakya P, et al. Effects of nutrition interventions during pregnancy on low birth weight: an overview of systematic reviews. BMJ Glob Health 2017;2:e000389.
    1. Dhaded SM, Hambidge KM, Ali SA, et al. Preconception nutrition intervention improved birth length and reduced stunting and wasting in newborns in South Asia: the Women First randomized controlled trial. PLoS One 2020;15:e0218960.
    1. Patton GC, Sawyer SM, Santelli JS, et al. Our future: a Lancet commission on adolescent health and wellbeing. Lancet 2016;387:2423–78.
    1. Christian P, Smith ER. Adolescent undernutrition: global burden, physiology, and nutritional risks. Ann Nutr Metab 2018;72:316–28.
    1. Marvin-Dowle K, Burley VJ, Soltani H. Nutrient intakes and nutritional biomarkers in pregnant adolescents: a systematic review of studies in developed countries. BMC Pregnancy Childbirth 2016;16:268.
    1. Hoellen F, Hornemann A, Haertel C, et al. Does maternal underweight prior to conception influence pregnancy risks and outcome? In Vivo 2014;28:1165–70.
    1. Mestman JH. Historical notes on diabetes and pregnancy. Endocrinologist 2002;12:224–42.
    1. Hernandez TL, Brand-Miller JC. Nutrition therapy in gestational diabetes mellitus: time to move forward. Diabetes Care 2018;41:1343–5.
    1. Freinkel N Banting Lecture 1980. Of pregnancy and progeny. Diabetes 1980;29:1023–35.
    1. Hernandez TL. Glycemic targets in pregnancies affected by diabetes: historical perspective and future directions. Curr Diab Rep 2015;15:565.
    1. Hernandez TL. Carbohydrate content in the GDM diet: two views: view 1: nutrition therapy in gestational diabetes: the case for complex carbohydrates. Diabetes Spectr 2016;29:82–8.
    1. Hernandez TL, Friedman JE, Barbour LA. Insulin resistance in pregnancy: implications for mother and offspring. Cham, Switzerland: Springer Nature Switzerland AG; 2019.
    1. Barbour LA, Hernandez TL. Maternal non-glycemic contributors to fetal growth in obesity and gestational diabetes: spotlight on lipids. Curr Diab Rep 2018;18:37.
    1. Metzger BE, Buchanan TA, Coustan DR, et al. Summary and recommendations of the Fifth International Workshop-Conference on Gestational Diabetes Mellitus. Diabetes Care 2007;30(Suppl2):S251–60.
    1. Han S, Middleton P, Shepherd E, Van Ryswyk E, Crowther CA. Different types of dietary advice for women with gestational diabetes mellitus. Cochrane Database Syst Rev 2017;2:CD009275.
    1. Tsirou E, Grammatikopoulou MG, Theodoridis X, et al. Guidelines for medical nutrition therapy in gestational diabetes mellitus: systematic review and critical appraisal. J Acad Nutr Diet 2019;119:1320–39.
    1. Hernandez TL, Mande A, Barbour LA. Nutrition therapy within and beyond gestational diabetes. Diabetes Res Clin Pract 2018;145:39–50.
    1. Barbour LA, Hernandez TL, Friedman JE. Metabolic changes during normal, obese, and GDM pregnancies. In Reece A, Coustan D, ed. Diabetes and obesity in women. Philadelphia, PA: Wolters Kluwer. . Accessed September 26, 2018.
    1. Barbour LA. Metabolic culprits in obese pregnancies and gestational diabetes mellitus: big babies, big twists, big picture: the 2018 Norbert Freinkel award lecture. Diabetes Care 2019;42:718–26.
    1. Simmons D Prevention of gestational diabetes mellitus: where are we now? Diabetes Obes Metab 2015;17:824–34.
    1. García-Patterson A, Balsells M, Yamamoto JM, et al. Usual dietary treatment of gestational diabetes mellitus assessed after control diet in randomized controlled trials: subanalysis of a systematic review and meta-analysis. Acta Diabetol 2019;56:237–40.
    1. Hernandez TL, Farabi SS, Jaron A, et al. 97-OR: randomization to a higher–complex carbohydrate vs. conventional diet in GDM improves glucose tolerance and results in similar cord blood insulin and newborn adiposity. Diabetes 2020;69.
    1. Yamamoto JM, Kellett JE, Balsells M, et al. Gestational diabetes mellitus and diet: a systematic review and meta-analysis of randomized controlled trials examining the impact of modified dietary interventions on maternal glucose control and neonatal birth weight. Diabetes Care 2018;41:1346–61.
    1. Courcoulas AP, King WC, Belle SH, et al. Seven-year weight trajectories and health outcomes in the longitudinal assessment of bariatric surgery (LABS) study. JAMA Surg 2018;153:427–34.
    1. Kwong W, Tomlinson G, Feig DS. Maternal and neonatal outcomes after bariatric surgery; a systematic review and meta-analysis: do the benefits outweigh the risks? Am J Obstet Gynecol 2018;218:573–80.
    1. Dutton H, Borengasser SJ, Gaudet LM, Barbour LA, Keely EJ. Obesity in pregnancy: optimizing outcomes for mom and baby. Med Clin North Am 2018;102:87–106.
    1. Burton GJ, Yung HW, Murray AJ. Mitochondrial - endoplasmic reticulum interactions in the trophoblast: stress and senescence. Placenta 2017;52:146–55.
    1. Chesly LC. Hyperensive disorders of pregnancy. New York, NY: Appleton-Century-Crofts; 1978.
    1. Brewer T Metabolic toxemia of late pregnancy: a disease entity. Gynaecologia 1969;167:1–8.
    1. Chesley LC. Hypertensive disorders in pregnancy. J Nurse Midwifery 1985;30:99–104.
    1. Robinson M Salt in pregnancy. Lancet 1958;1:178–81.
    1. Hofmeyr GJ, Lawrie TA, Atallah AN, Torloni MR. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev 2018;10:CD001059.
    1. Rumbold A, Ota E, Hori H, Miyazaki C, Crowther CA. Vitamin E supplementation in pregnancy. Cochrane Database Syst Rev 2015;9:CD004069.
    1. Rumbold A, Ota E, Nagata C, Shahrook S, Crowther CA. Vitamin C supplementation in pregnancy. Cochrane Database Syst Rev 2015;2015:CD004072.
    1. Bulloch RE, Lovell AL, Jordan VMB, McCowan LME, Thompson JMD, Wall CR. Maternal folic acid supplementation for the prevention of preeclampsia: a systematic review and meta-analysis. Paediatr Perinat Epidemiol 2018;32:346–57.
    1. Achamrah N, Ditisheim A. Nutritional approach to preeclampsia prevention. Curr Opin Clin Nutr Metab Care 2018;21:168–73.
    1. Wilson RL, Grieger JA, Bianco-Miotto T, Roberts CT. Association between maternal zinc status, dietary zinc intake and pregnancy complications: a systematic review. Nutrients 2016;8:641.
    1. Xiao Y, Sun H, Li C, et al. Effect of iodine nutrition on pregnancy outcomes in an iodine-sufficient area in China. Biol Trace Elem Res 2018;182:231–7.
    1. Kinshella MW, Omar S, Scherbinsky K, et al. Effects of maternal nutritional supplements and dietary interventions on placental complications: an umbrella review, meta-analysis and evidence map. Nutrients 2021;13:472.
    1. Smeeth L, Williams D. Can a dietary supplement prevent pre-eclampsia? BMJ 2011;342:d2777.
    1. Bodnar LM, Tang G, Ness RB, Harger G, Roberts JM. Periconceptional multivitamin use reduces the risk of preeclampsia. Am J Epidemiol 2006;164:470–7.
    1. Catov JM, Nohr EA, Bodnar LM, Knudson VK, Olsen SF, Olsen J. Association of periconceptional multivitamin use with reduced risk of preeclampsia among normal-weight women in the Danish National Birth Cohort. Am J Epidemiol 2009;169:1304–11.
    1. Vanderlelie J, Scott R, Shibl R, Lewkowicz J, Perkins A, Scuffham PA. First trimester multivitamin/mineral use is associated with reduced risk of pre-eclampsia among overweight and obese women. Matern Child Nutr 2016;12:339–48.
    1. Ormesher L, Myers JE, Chmiel C, et al. Effects of dietary nitrate supplementation, from beetroot juice, on blood pressure in hypertensive pregnant women: a randomised, double-blind, placebo-controlled feasibility trial. Nitric Oxide 2018;80:37–44.
    1. Rakova N, Muller DN, Staff AC, Luft FC, Dechend R. Novel ideas about salt, blood pressure, and pregnancy. J Reprod Immunol 2014;101–102:135–9.
    1. Cindrova-Davies T The therapeutic potential of antioxidants, ER chaperones, NO and H2S donors, and statins for treatment of preeclampsia. Front Pharmacol 2014;5:119.
    1. Kar S, Wong M, Rogozinska E, Thangaratinam S. Effects of omega-3 fatty acids in prevention of early preterm delivery: a systematic review and meta-analysis of randomized studies. Eur J Obstet Gynecol Reprod Biol 2016;198:40–6.
    1. Amati F, Hassounah S, Swaka A. The impact of Mediterranean dietary patterns during pregnancy on maternal and offspring health. Nutrients 2019;11:1098.
    1. Biagi C, Nunzio MD, Bordoni A, Gori D, Lanari M. Effect of adherence to Mediterranean diet during pregnancy on children’s health: a systematic review. Nutrients 2019;11:997.
    1. Chen X, Zhao D, Mao X, Xia Y, Baker PN, Zhang H. Maternal dietary patterns and pregnancy outcome. Nutrients 2016;8:351.
    1. Kibret KT, Chojenta C, Gresham E, Tegegne TK, Loxton D. Maternal dietary patterns and risk of adverse pregnancy (hypertensive disorders of pregnancy and gestational diabetes mellitus) and birth (preterm birth and low birth weight) outcomes: a systematic review and meta-analysis. Public Health Nutr 2018:1–15.
    1. Zhang Y, Lin J, Fu W, Liu S, Gong C, Dai J. Mediterranean diet during pregnancy and childhood for asthma in children: a systematic review and meta-analysis of observational studies. Pediatr Pulmonol 2019;54:949–61.
    1. Vujkovic M, de Vries JH, Lindemans J, et al. The preconception Mediterranean dietary pattern in couples undergoing in vitro fertilization/intracytoplasmic sperm injection treatment increases the chance of pregnancy. Fertil Steril 2010;94:2096–101.
    1. US Food and Drug Administration. FDA issues revised “Advice about eating fish: for women who are or might become pregnant, breastfeeding mothers, and young children.” Food and Drug Administration. 2019. Available at: . Accessed November 11, 2021.
    1. Vlaardingerbroek H Unusual cause of congenital hypothyroidism in a term infant. BMJ Case Rep 2021;14:e237930.
    1. Mise N, Ohtsu M, Ikegami A, et al. Hijiki seaweed consumption elevates levels of inorganic arsenic intake in Japanese children and pregnant women. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2019;36:84–95.
    1. Desrosiers TA, Siega-Riz AM, Mosley BS, Meyer RE. National Birth Defects Prevention Study. Low carbohydrate diets may increase risk of neural tube defects. Birth Defects Res 2018;110:901–9.
    1. Hernandez TL, Van Pelt RE, Anderson MA, et al. Women with gestational diabetes mellitus randomized to a higher-complex carbohydrate/low-fat diet manifest lower adipose tissue insulin resistance, inflammation, glucose, and free fatty acids: a pilot study. Diabetes Care 2016;39:39–42.
    1. Godfrey KM, Sheppard A, Gluckman PD, et al. Epigenetic gene promoter methylation at birth is associated with child’s later adiposity. Diabetes 2011;60:1528–34.
    1. Barker DJP, Thornburg KL. The obstetric origins of health for a lifetime. Clin Obstet Gynecol 2013;56:511–9.
    1. Holme AM, Roland MC, Lorentzen B, Michelsen TM, Henriksen T. Placental glucose transfer: a human in vivo study. PLoS One 2015;10:e0117084.
    1. Lavie M, Lavie I, Maslovitz S. Paleolithic diet during pregnancy-a potential beneficial effect on metabolic indices and birth weight. Eur J Obstet Gynecol Reprod Biol 2019;242:7–11.
    1. Shapiro ALB, Kaar JL, Crume TL, et al. Maternal diet quality in pregnancy and neonatal adiposity: the Healthy Start Study. Int J Obes (Lond) 2016;40:1056–62.
    1. LifeCycle Project-Maternal Obesity and Childhood Outcomes Study Group, Voerman E, Santos S, et al. Association of gestational weight gain with adverse maternal and infant outcomes. JAMA 2019;321:1702–15.
    1. Rogozińska E, Zamora J, Marlin N, et al. Gestational weight gain outside the Institute of Medicine recommendations and adverse pregnancy outcomes: analysis using individual participant data from randomised trials. BMC Pregnancy Childbirth 2019;19:322.
    1. Nicklas JM, Barbour LA. Optimizing weight for maternal and infant health - tenable, or too late? Expert Rev Endocrinol Metab 2015;10:227–42.
    1. Scott C, Andersen CT, Valdez N, et al. No global consensus: a cross-sectional survey of maternal weight policies. BMC Pregnancy Childbirth 2014;14:167.
    1. Deputy NP, Sharma AJ, Kim SY, Olson CK. Achieving appropriate gestational weight gain: the role of healthcare provider advice. J Womens Health (Larchmt) 2018;27:552–60.
    1. Rogerson D, Soltani H, Copeland R. Undergraduate UK nutrition education might not adequately address weight management. Public Health Nutr 2016;19:371–81.
    1. Kominiarek MA, Seligman NS, Dolin C, et al. Gestational weight gain and obesity: is 20 pounds too much? Am J Obstet Gynecol 2013;209:214.e1–11.
    1. Bodnar LM, Pugh SJ, Lash TL, et al. Low gestational weight gain and risk of adverse perinatal outcomes in obese and severely obese women. Epidemiology 2016;27:894–902.
    1. Catalano PM, Mele L, Landon MB, et al. Inadequate weight gain in overweight and obese pregnant women: what is the effect on fetal growth? Am J Obstet Gynecol 2014;211:137. e1–7.
    1. Bodnar LM, Siminerio LL, Himes KP, et al. Maternal obesity and gestational weight gain are risk factors for infant death. Obesity (Silver Spring) 2016;24:490–8.
    1. Faucher MA, Barger MK. Gestational weight gain in obese women by class of obesity and select maternal/newborn outcomes: a systematic review. Women Birth 2015;28:e70–9.
    1. Cantor AG, Jungbauer RM, McDonagh M, et al. Counseling and behavioral interventions for healthy weight and weight gain in pregnancy: evidence report and systematic review for the US Preventive Services Task Force. JAMA 2021;325:2094–109.
    1. US Preventive Services Task Force, Davidson KW, Barry MJ, et al. Behavioral counseling interventions for healthy weight and weight gain in pregnancy: US Preventive Services Task Force recommendation statement. JAMA 2021;325:2087–93.
    1. Bauserman MS, Bann CM, Hambidge KM, et al. Gestational weight gain in 4 low- and middle-income countries and associations with birth outcomes: a secondary analysis of the Women First Trial. Am J Clin Nutr 2021;114:804–12.
    1. Bartick MC, Schwarz EB, Green BD, et al. Suboptimal breastfeeding in the United States: maternal and pediatric health outcomes and costs. Matern Child Nutr 2017;13:e12366.
    1. Section on Breastfeeding. Breastfeeding and the use of human milk. Pediatrics 2012;129:e827–41.
    1. Rasmussen KM. The influence of maternal nutrition on lactation. Annu Rev Nutr 1992;12:103–17.
    1. John A, Sun R, Maillart L, Schaefer A, Hamilton Spence E, Perrin MT. Macronutrient variability in human milk from donors to a milk bank: implications for feeding preterm infants. PLoS One 2019;14:e0210610.
    1. Perrin MT, Fogleman AD, Newburg DS, Allen JC. A longitudinal study of human milk composition in the second year postpartum: implications for human milk banking. Matern Child Nutr 2017;13.
    1. Khan S, Hepworth AR, Prime DK, Lai CT, Trengove NJ, Hartmann PE. Variation in fat, lactose, and protein composition in breast milk over 24 hours: associations with infant feeding patterns. J Hum Lact 2013;29:81–9.
    1. Del Prado M, Villalpando S, Elizondo A, Rodríguez M, Demmelmair H, Koletzko B. Contribution of dietary and newly formed arachidonic acid to human milk lipids in women eating a low-fat diet. Am J Clin Nutr 2001;74:242–7.
    1. Khodabakhshi A, Mehrad-Majd H, Vahid F, Safarian M. Association of maternal breast milk and serum levels of macronutrients, hormones, and maternal body composition with infant’s body weight. Eur J Clin Nutr 2018;72:394–400.
    1. Spahn JM, Callahan EH, Spill MK, et al. Influence of maternal diet on flavor transfer to amniotic fluid and breast milk and children’s responses: a systematic review. Am J Clin Nutr 2019;109:1003–1026S.
    1. Rudolph MC, Young BE, Lemas DJ, et al. Early infant adipose deposition is positively associated with the n-6 to n-3 fatty acid ratio in human milk independent of maternal BMI. Int J Obes (Lond) 2017;41:510–7.
    1. Lemas DJ, Young BE, Baker PR 2nd, et al. Alterations in human milk leptin and insulin are associated with early changes in the infant intestinal microbiome. Am J Clin Nutr 2016;103:1291–300.
    1. Rodel RL, Carli JM, Hirsch NM, et al. Human milk composition in type 2 diabetes imparts higher insulin exposure. Diabetes 2019;68(Suppl1). 1422–P.
    1. Gunderson EP, Hurston SR, Ning X, et al. Lactation and progression to type 2 diabetes mellitus after gestational diabetes mellitus: a prospective cohort study. Ann Intern Med 2015;163:889–98.
    1. Gunderson EP, Lewis CE, Lin Y, et al. Lactation duration and progression to diabetes in women across the childbearing years: the 30-year CARDIA study. JAMA Intern Med 2018;178:328–37.
    1. Choi SR, Kim YM, Cho MS, Kim SH, Shim YS. Association between duration of breast feeding and metabolic syndrome: the Korean National Health and Nutrition Examination Surveys. J Womens Health (Larchmt) 2017;26:361–7.
    1. Peters SAE, Yang L, Guo Y, et al. Breastfeeding and the risk of maternal cardiovascular disease: a prospective study of 300 000 Chinese women. J Am Heart Assoc 2017;6:e006081.
    1. Chowdhury R, Sinha B, Sankar MJ, et al. Breastfeeding and maternal health outcomes: a systematic review and meta-analysis. Acta Paediatr 2015;104:96–113.
    1. Marshall NE, Lau B, Purnell JQ, Thornburg KL. Impact of maternal obesity and breastfeeding intention on lactation intensity and duration. Matern Child Nutr 2019;15:e12732.
    1. Wilson RD, Genetics Committee, Wilson RD, et al. Pre-conception folic acid and multivitamin supplementation for the primary and secondary prevention of neural tube defects and other folic acid-sensitive congenital anomalies. J Obstet Gynaecol Can 2015;37:534–52.
    1. Guinotte CL, Burns MG, Axume JA, et al. Methylenetetrahydrofolate reductase 677C-> T variant modulates folate status response to controlled folate intakes in young women. J Nutr 2003;133:1272–80.
    1. Institute of Medicine (US) Committee on Nutritional Status During Pregnancy and Lactation. Nutrition during pregnancy: part I weight gain: part II nutrient supplements. Washington, DC: National Academies Press (US); 1990.
    1. Le CH. The prevalence of anemia and moderate-severe anemia in the US population (NHANES 2003–2012). PLoS One 2016;11:e0166635.
    1. Stevens GA, Finucane MM, De-Regil LM, et al. Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995–2011: a systematic analysis of population-representative data. Lancet Glob Health 2013;1:e16–25.
    1. Dewey KG, Oaks BM. U-shaped curve for risk associated with maternal hemoglobin, iron status, or iron supplementation. Am J Clin Nutr 2017;106(Suppl6):1694–1702S.
    1. Smith ER, Shankar AH, Wu LS, et al. Modifiers of the effect of maternal multiple micronutrient supplementation on stillbirth, birth outcomes, and infant mortality: a meta-analysis of individual patient data from 17 randomised trials in low-income and middle-income countries. Lancet Glob Health 2017;5:e1090–100.
    1. Caudill MA, Strupp BJ, Muscalu L, Nevins JEH, Canfield RL. Maternal choline supplementation during the third trimester of pregnancy improves infant information processing speed: a randomized, double-blind, controlled feeding study. FASEB J 2018;32:2172–80.
    1. Jacobson SW, Carter RC, Molteno CD, et al. Efficacy of maternal choline supplementation during pregnancy in mitigating adverse effects of prenatal alcohol exposure on growth and cognitive function: a randomized, double-blind, placebo-controlled clinical trial. Alcohol Clin Exp Res 2018;42:1327–41.
    1. Derbyshire E, Obeid R. Choline, neurological development and brain function: a systematic review focusing on the first 1000 days. Nutrients 2020:12:1731.
    1. Freedman R, Hunter SK, Law AJ, et al. Higher gestational choline levels in maternal infection are protective for infant brain development. J Pediatr 2019;208:198–206.e2.
    1. World Health Organization and knowledge translation in maternal, newborn, child and adolescent health and nutrition, Arch Dis Child 2021. Dec 30, 10.1136/archdischild-2021-323102.
    1. Gernand AD, Schulze KJ, Stewart CP, West KP Jr, Christian P. Micronutrient deficiencies in pregnancy worldwide: health effects and prevention. Nat Rev Endocrinol 2016;12:274–89.
    1. Most J, Dervis S, Haman F, Adamo KB, Redman LM. Energy intake requirements in pregnancy. Nutrients 2019;11:1812.
    1. Darnton-Hill I, Mkparu UC. Micronutrients in pregnancy in low- and middle-income countries. Nutrients 2015;7:1744–68.
    1. Pearce EN, Lazarus JH, Moreno-Reyes R, Zimmermann MB. Consequences of iodine deficiency and excess in pregnant women: an overview of current knowns and unknowns. Am J Clin Nutr 2016;104:918–923S.
    1. Alexander EK, Pearce EN, Brent GA, et al. 2017 Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid 2017;27:315–89.
    1. Miranda A, Sousa N. Maternal hormonal milieu influence on fetal brain development. Brain Behav 2018;8:e00920.
    1. Vermiglio F, Lo Presti VP, Moleti M, et al. Attention deficit and hyperactivity disorders in the offspring of mothers exposed to mild-moderate iodine deficiency: a possible novel iodine deficiency disorder in developed countries. J Clin Endocrinol Metab 2004;89:6054–60.
    1. Krebs-Smith SM, Pannucci TE, Subar AF, et al. Update of the healthy eating index: HEI-2015. J Acad Nutr Diet 2018;118:1591–602.
    1. Tahir MJ, Haapala JL, Foster LP, et al. Higher maternal diet quality during pregnancy and lactation is associated with lower infant weight-for-length, body fat percent, and fat mass in early postnatal life. Nutrients 2019;11:632.
    1. Sen S, Rifas-Shiman SL, Shivappa N, et al. Associations of prenatal and early life dietary inflammatory potential with childhood adiposity and cardiometabolic risk in Project Viva. Pediatr Obes 2018;13:292–300.
    1. Widen E, Siega-Riz AM. Prenatal nutrition: a practical guide for assessment and counseling. J Midwifery Womens Health 2010;55:540–9.
    1. Anderson AS. Symposium on ‘nutritional adaptation to pregnancy and lactation.’ Pregnancy as a time for dietary change? Proc Nutr Soc 2001;60:497–504.
    1. Daru J, Allotey J, Peña-Rosas JP, Khan KS. Serum ferritin thresholds for the diagnosis of iron deficiency in pregnancy: a systematic review. Transfus Med 2017;27:167–74.
    1. Harris WS, Luo J, Pottala JV, Margolis KL, Espeland MA, Robinson JG. Red blood cell fatty acids and incident diabetes mellitus in the Women’s Health Initiative memory study. PLoS One 2016;11:e0147894.
    1. Baack ML, Puumala SE, Messier SE, Pritchett DK, Harris WS. Daily enteral DHA supplementation alleviates deficiency in premature infants. Lipids 2016;51:423–33.
    1. Harris WS, Tintle NL, Etherton MR, Vasan RS. Erythrocyte long-chain omega-3 fatty acid levels are inversely associated with mortality and with incident cardiovascular disease: the Framingham Heart Study. J Clin Lipidol 2018;12:718–27.e6.
    1. Lee A, Newton M, Radcliffe J, Belski R. Pregnancy nutrition knowledge and experiences of pregnant women and antenatal care clinicians: a mixed methods approach. Women Birth 2018;31:269–77.
    1. National Institute for Health and Care Excellence. Weight management before, during and after pregnancy. National Institute for Health and Care Excellence. 2010. Available at: . Accessed November 11, 2021.
    1. Arden MA, Duxbury AM, Soltani H. Responses to gestational weight management guidance: a thematic analysis of comments made by women in online parenting forums. BMC Pregnancy Childbirth 2014;14:216.
    1. Daley AJ, Jolly K, Jebb SA, et al. Effectiveness of regular weighing, weight target setting and feedback by community midwives within routine antenatal care in preventing excessive gestational weight gain: randomised controlled trial. BMC Obes 2015;3:7.
    1. Fealy S, Davis D, Foureur M, Attia J, Hazelton M, Hure A. The return of weighing in pregnancy: a discussion of evidence and practice. Women Birth 2020;33:119–24.
    1. Percival J Promoting health: making every contact count. Nurs Stand 2014;28:37–41.
    1. Dean SV, Lassi ZS, Imam AM, Bhutta ZA. Preconception care: nutritional risks and interventions. Reprod Health 2014;11 (Suppl3):S3.
    1. Lassi ZS, Moin A, Das JK, Salam RA, Bhutta ZA. Systematic review on evidence-based adolescent nutrition interventions. Ann N Y Acad Sci 2017;1393:34–50.
    1. Sherifali D, Nerenberg KA, Wilson S, et al. The effectiveness of eHealth technologies on weight management in pregnant and postpartum women: systematic review and meta-analysis. J Med Internet Res 2017;19:e337.
    1. Gage SH, Munafò MR, Davey Smith G. Causal inference in developmental origins of health and disease (DOHaD) research. Annu Rev Psychol 2016;67:567–85.
    1. Stiemsma LT, Michels KB. The role of the microbiome in the developmental origins of health and disease. Pediatrics 2018;141:e20172437.
    1. Castanys-Muñoz E, Martin MJ, Vazquez E. Building a beneficial microbiome from birth. Adv Nutr 2016;7:323–30.
    1. Pascale A, Marchesi N, Marelli C, et al. Microbiota and metabolic diseases. Endocrine 2018;61:357–71.
    1. Peña-Romero AC, Navas-Carrillo D, Marín F, Orenes-Piñero E. The future of nutrition: nutrigenomics and nutrigenetics in obesity and cardiovascular diseases. Crit Rev Food Sci Nutr 2018;58:3030–41.
    1. Han MM, Sun JF, Su XH, et al. Probiotics improve glucose and lipid metabolism in pregnant women: a meta-analysis. Ann Transl Med 2019;7:99.
    1. Jarde A, Lewis-Mikhael AM, Moayyedi P, et al. Pregnancy outcomes in women taking probiotics or prebiotics: a systematic review and meta-analysis. BMC Pregnancy Childbirth 2018;18:14.
    1. Murphy HR, Rayman G, Duffield K, et al. Changes in the glycemic profiles of women with type 1 and type 2 diabetes during pregnancy. Diabetes Care 2007;30:2785–91.
    1. Feig DS, Donovan LE, Corcoy R, et al. Continuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT): a multicentre international randomised controlled trial. Lancet 2017;390:2347–59.
    1. Stewart ZA, Wilinska ME, Hartnell S, et al. Day-and-night closed-loop insulin delivery in a broad population of pregnant women with type 1 diabetes: a randomized controlled crossover trial. Diabetes Care 2018;41:1391–9.
    1. Secher AL, Ringholm L, Andersen HU, Damm P, Mathiesen ER. The effect of real-time continuous glucose monitoring in pregnant women with diabetes: a randomized controlled trial. Diabetes Care 2013;36:1877–83.
    1. Paramasivam SS, Chinna K, Singh AKK, et al. Continuous glucose monitoring results in lower HbA1c in Malaysian women with insulin-treated gestational diabetes: a randomized controlled trial. Diabet Med 2018;35:1118–29.
    1. Wallace JM, Agard JP, Horgan GW. A new customised placental weight standard redefines the relationship between maternal obesity and extremes of placental size and is more closely associated with pregnancy complications than an existing population standard. J Dev Orig Health Dis 2020;11:350–9.
    1. Stuart JJ, Bairey Merz CN, Berga SL, et al. Maternal recall of hypertensive disorders in pregnancy: a systematic review. J Womens Health (Larchmt) 2013;22:37–I7.
    1. GBD 2017 Diet Collaborators. Health effects of dietary risks in 195 countries, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2019;393:1958–72.
    1. American College of Obstetricians and Gynecologists. ACOG Committee Opinion No. 548: weight gain during pregnancy. Obstet Gynecol 2013;121:210–2.

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