Active Gains in brain Using Exercise During Aging (AGUEDA): protocol for a randomized controlled trial

Patricio Solis-Urra, Cristina Molina-Hidalgo, Yolanda García-Rivero, Claudia Costa-Rodriguez, Jose Mora-Gonzalez, Beatriz Fernandez-Gamez, Marcos Olvera-Rojas, Andrea Coca-Pulido, Angel Toval, Darío Bellón, Alessandro Sclafani, Isabel Martín-Fuentes, Eva María Triviño-Ibañez, Carlos de Teresa, Haiqing Huang, George Grove, Charles H Hillman, Arthur F Kramer, Andrés Catena, Francisco B Ortega, Manuel Gómez-Río, Kirk I Erickson, Irene Esteban-Cornejo, Patricio Solis-Urra, Cristina Molina-Hidalgo, Yolanda García-Rivero, Claudia Costa-Rodriguez, Jose Mora-Gonzalez, Beatriz Fernandez-Gamez, Marcos Olvera-Rojas, Andrea Coca-Pulido, Angel Toval, Darío Bellón, Alessandro Sclafani, Isabel Martín-Fuentes, Eva María Triviño-Ibañez, Carlos de Teresa, Haiqing Huang, George Grove, Charles H Hillman, Arthur F Kramer, Andrés Catena, Francisco B Ortega, Manuel Gómez-Río, Kirk I Erickson, Irene Esteban-Cornejo

Abstract

Alzheimer's disease is currently the leading cause of dementia and one of the most expensive, lethal and severe diseases worldwide. Age-related decline in executive function is widespread and plays a key role in subsequent dementia risk. Physical exercise has been proposed as one of the leading non-pharmaceutical approaches to improve executive function and ameliorate cognitive decline. This single-site, two-arm, single-blinded, randomized controlled trial (RCT) will include 90 cognitively normal older adults, aged 65-80 years old. Participants will be randomized to a 24-week resistance exercise program (3 sessions/week, 60 min/session, n = 45), or a wait-list control group (n = 45) which will be asked to maintain their usual lifestyle. All study outcomes will be assessed at baseline and at 24-weeks after the exercise program, with a subset of selected outcomes assessed at 12-weeks. The primary outcome will be indicated by the change in an executive function composite score assessed with a comprehensive neuropsychological battery and the National Institutes of Health Toolbox Cognition Battery. Secondary outcomes will include changes in brain structure and function and amyloid deposition, other cognitive outcomes, and changes in molecular biomarkers assessed in blood, saliva, and fecal samples, physical function, muscular strength, body composition, mental health, and psychosocial parameters. We expect that the resistance exercise program will have positive effects on executive function and related brain structure and function, and will help to understand the molecular, structural, functional, and psychosocial mechanisms involved.

Keywords: Alzheimer’s disease; amyloid beta; brain; executive function; exercise.

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Copyright © 2023 Solis-Urra, Molina-Hidalgo, García-Rivero, Costa-Rodriguez, Mora-Gonzalez, Fernandez-Gamez, Olvera-Rojas, Coca-Pulido, Toval, Bellón, Sclafani, Martín-Fuentes, Triviño-Ibañez, de Teresa, Huang, Grove, Hillman, Kramer, Catena, Ortega, Gómez-Río, Erickson and Esteban-Cornejo.

Figures

FIGURE 1
FIGURE 1
Visual representation of the participant flow in the AGUEDA trial. PA, physical activity; STICS-m, Modified Spanish Telephone Interview of Cognitive Status; MoCA, Montreal Cognitive Assessment; GDS, Geriatric Depression Scale; DXA, dual energy X-ray absorptiometry; MMSE, Mini-Mental State Examination; MRI, Magnetic Resonance Imaging; PET, positron emission tomography. *Wait-list control group is asked to maintain its lifestyles during the 24-week and start the exercise program after post-intervention assessment. #Post-intervention assessment includes the same outcomes that baseline assessment.

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