Mesenchymal stromal cells and the innate immune response
Katarina Le Blanc, Lindsay C Davies, Katarina Le Blanc, Lindsay C Davies
Abstract
Mesenchymal stromal cells (MSC) have been exploited for their immunomodulatory properties in the treatment of a number of immune-based disorders, including Graft versus Host Disease (GvHD) and type 1 diabetes. The mechanisms for inducing therapeutic effect still remain largely unknown however, with research focused on understanding how MSCs interact with individual immune cell subsets. Within this review we address what is known about the interactions of MSCs with cells of the innate immune system, how they respond to their microenvironment and how this relates to therapeutic effects we see both within in vivo animal models and in clinical trials.
Keywords: Immunomodulation; Inflammation; Innate immunity; Mesenchymal stromal cells.
Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.
Source: PubMed