Estimating the financial cost of chronic kidney disease to the NHS in England

Marion Kerr, Benjamin Bray, James Medcalf, Donal J O'Donoghue, Beverley Matthews, Marion Kerr, Benjamin Bray, James Medcalf, Donal J O'Donoghue, Beverley Matthews

Abstract

Background: Chronic kidney disease (CKD) is a major challenge for health care systems around the world, and the prevalence rates appear to be increasing. We estimate the costs of CKD in a universal health care system.

Methods: Economic modelling was used to estimate the annual cost of Stages 3-5 CKD to the National Health Service (NHS) in England, including CKD-related prescribing and care, renal replacement therapy (RRT), and excess strokes, myocardial infarctions (MIs) and Methicillin-Resistant Staphylococcus Aureus (MRSA) infections in people with CKD.

Results: The cost of CKD to the English NHS in 2009-10 is estimated at £ 1.44 to £ 1.45 billion, which is ≈ 1.3% of all NHS spending in that year. More than half this sum was spent on RRT, which was provided for 2% of the CKD population. The economic model estimates that ≈ 7000 excess strokes and 12 000 excess MIs occurred in the CKD population in 2009-10, relative to an age- and gender-matched population without CKD. The cost of excess strokes and MIs is estimated at £ 174-£ 178 million.

Conclusions: The financial impact of CKD is large, with particularly high costs relating to RRT and cardiovascular complications. It is hoped that these detailed cost estimates will be useful in analysing the cost-effectiveness of treatments for CKD.

Figures

Fig. 1
Fig. 1
Distribution of costs attributable to CKD (to the nearest £million), 2009–10. Where estimates have been calculated as a range, the higher figure is shown.
Fig. 2
Fig. 2
Estimated annual cost of direct CKD care, RRT and non-RRT patients.

References

    1. Coresh J, Astor BC, Greene T, et al. Prevalence of chronic kidney disease and decreased kidney function in the adult US population: third National Health and Nutrition Examination Survey. Am J Kidney Dis. 2003;41:1–12.
    1. Hamer RA, El Nahas AM. The burden of chronic kidney disease. BMJ. 2006;332:563–564.
    1. Stevens PE, O'Donoghue DJ, de Lusignan S, et al. Chronic kidney disease management in the United Kingdom: NEOERICA project results. Kidney Int. 2007;72:92–99.
    1. de Lusignan S, Tomson C, Harris K, et al. Creatinine fluctuation has a greater effect than the formula to estimate glomerular filtration rate on the prevalence of chronic kidney disease. Nephron Clin Pract. 2011;117:c213–c224.
    1. Roth M, Roderick P, Mindell J. Kidney disease and renal function. In: Craig R, Mindell J, editors. Health Survey for England. 2010: England, UK: The Health and Social Care Information Centre; 2011.
    1. Ansell D, Feest T. The Third Annual Report. Bristol, UK: The UK Renal Registry; 2000.
    1. Bristol, UK: The UK Renal Registry; 2010. The Thirteenth Annual Report.
    1. Wanless D. London, UK: HM Treasury; 2002. Securing our Future Health: Taking a Long-term View Final Report; pp. 13–34.
    1. Programme Budgeting Tools and Data. National expenditure data. London, UK: Department of Health; . (2 December 2011, date last accessed)
    1. National Collaborating Centre for Chronic Conditions. Chronic Kidney Disease: National Clinical Guideline for Early Identification and Management in Adults in Primary and Secondary Care. London: Royal College of Physicians; 2008.
    1. Go AS, Chertow GM, Fan D, et al. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351:1296–1305.
    1. Weiner DE, Tighiouart H, Amin GM, et al. Chronic Kidney Disease as a Risk Factor for Cardiovascular Disease and All-Cause Mortality: a pooled analysis of community-based studies. J Am Soc Nephrol. 2004;15:1307–1315.
    1. NHS Information Centre for Health and Social Care QOF 2009–10. . (2 December 2011, date last accessed)
    1. NHS Reference Costs 2009–10. London, UK: Department of Health; 2011. . 1 December 2011, date last accessed)
    1. NHS Blood and Transplant. UK: 2010. Transplant Activity in the UK Activity Report 2009–10. . (Accessed 11/12/12)
    1. Curtis L. Unit Costs of Health and Social Care PSSRU. Canterbury, UK: University of Kent; 2010.
    1. Farmer C, Irving J, Karunaratne K. 2011. What does it actually cost to improve population blood pressure control? Abstract, World Congress of Nephrology.
    1. Chaudhury M. Hypertension. In: Craig R, Mindell J, editors. Health Survey for England 2006 Volume 1 Cardiovascular Disease and Risk Factors in adults. UK: The Information Centre; 2008. pp. 43–62.
    1. Organs for Transplants: An Analysis of the Current Costs of the NHS Transplant Programme; the Costs of Alternative Medical Treatments, and the Impact of Increasing Organ Donation. NHS West Midlands Specialised Commissioning Team. UK: 2010. . (Accessed 11/12/12)
    1. NHS Kidney Care. UK: 2010. Developing robust reference costs for kidney transplantation in adults Final report. (Accessed 11/12/12)
    1. .
    1. NHS Institute for Innovation and Improvement. . (2 December 2011, date last accessed)
    1. Bristol, UK: The UK Renal Registry; 2009. The Twelfth Annual Report.
    1. Plowman R, Graves N, Griffin M, et al. The Socio-economic Burden of Hospital Acquired Infection. UK: Public Health Laboratory Service; 1999.
    1. KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease–mineral and bone disorder (CKD–MBD) Kidney Int. 2009;76:S1–130.
    1. Cumming AD, et al. Diarrhoea due to Clostridium difficile associated with antibiotic treatment in patients receiving dialysis; the role of cross infection. BMJ. 1986;292:238–239.
    1. Cunney RJ, et al. Clostridium difficile colitis associated with chronic renal failure. Nephrol Dial Transplant. 1998;13:2842–2846.
    1. US Renal Data System. Bethesda, MD, USA: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2009. USRDS Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States.
    1. National Collaborating Centre for Chronic Conditions. London, UK: Royal College of Physicians; 2008. Chronic Kidney Disease: National Clinical Guideline for Early Identification and Management in Adults in Primary and Secondary Care. Appendix C Health Economic Model—Cost Effectiveness of CKD Case Finding Among People at High Risk.
    1. Jafar THJ, Schmid CH, Landa M, et al. Angiotensin-converting enzyme inhibitors and progression of nondiabetic renal disease. Ann Intern Med. 2001;135:73–87.
    1. Baboolal K, McEwan P, Sondhi S, et al. The cost of renal dialysis in a UK setting—a multicentre study. Nephrol Dial Transplant. 2008;23:1982–1989.
    1. Peritoneal Dialysis in the Treatment of Stage 5 Chronic Kidney Disease. London, UK: NICE; 2011.
    1. Kidney Dialysis—Developing Costs to Deliver an Equitable and High Quality Service. London, UK: NHS Kidney Care; 2009.
    1. Kirby L, Vale L. Dialysis for end-stage renal disease determining a cost-effective approach. Int J Technol Assess Health Care. 2001;17:181–189.
    1. Truelsen T, Piechowski-Jóźwiak B, Bonita R, et al. Stroke incidence and prevalence in Europe: a review of available data. Eur J Neurol. 2006;13:581–598.
    1. Weiner DE, Tighiouart H, Levey AS, et al. Lowest systolic blood pressure is associated with stroke in Stages 3–4 chronic kidney disease. J Am Soc Nephrol. 2007;18:960–966.
    1. Iseki K, Kinjo K, Kimura Y, et al. Evidence for high risk of cerebral hemorrhage in chronic dialysis patients. Kidney Int. 1993;44:1086–1090.
    1. National Audit Office. Reducing Brain Damage: Faster Access to Better Stroke Care. London, UK: The Stationery Office; 2005.
    1. . (28 June 2011, date last accessed)
    1. Meisinger C, Döring A, Löwel H. Chronic kidney disease and risk of incident myocardial infarction and all-cause and cardiovascular disease mortality in middle-aged men and women from the general population. Eur Heart J. 2006;27:1245–1250.
    1. National Institute for Health and Clinical Excellence. UK: 2008. Lipid Modification: Costing Report. . (Accessed 11/12/12)

Source: PubMed

3
Subskrybuj