Luteal phase progesterone increases live birth rate after frozen embryo transfer
Kerstin Bjuresten, Britt-Marie Landgren, Outi Hovatta, Anneli Stavreus-Evers, Kerstin Bjuresten, Britt-Marie Landgren, Outi Hovatta, Anneli Stavreus-Evers
Abstract
Objective: To see if progesterone support has a beneficial effect on live birth rate after frozen embryo transfer in natural cycles.
Design: Prospective randomized controlled trial.
Setting: University-based hospital.
Subject(s): Four hundred thirty-five women undergoing embryo transfer in natural cycles.
Intervention(s): The women received either vaginal progesterone, 400 mg twice a day from the day of embryo transfer in natural cycles, or no progesterone support.
Main outcome measure(s): Live birth rate, biochemical pregnancy rate, pregnancy rate, and spontaneous abortion rate.
Result(s): Live birth rate were significantly greater in women receiving vaginal progesterone as luteal phase support after frozen-thawed embryo transfer in natural cycles compared with those who did not take progesterone. There were no differences in biochemical pregnancy rate, pregnancy rate, or spontaneous abortion rate.
Conclusion(s): Progesterone supplementation improves live birth rate after embryo transfer in natural cycles.
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Source: PubMed