Time for better time-restricted eating trials to lessen the burden of metabolic diseases
Pam R Taub, Satchidananda Panda, Pam R Taub, Satchidananda Panda
Abstract
Optimizing the quality, quantity, and timing of nutrition holds immense potential to improve health and prevent disease. The results of a recent randomized controlled trial1 have been widely misrepresented with the incorrect interpretation that optimizing the timing of food intake imparts no health benefits.
Trial registration: ClinicalTrials.gov NCT04057339 NCT05365529.
Conflict of interest statement
Declaration of interests S.P. is the author of the books The Circadian Code and The Circadian Diabetes Code.
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
References
- Liu D., Huang Y., Huang C., Yang S., Wei X., Zhang P., Guo D., Lin J., Xu B., Li C., et al. Calorie restriction with or without time-restricted eating in weight loss. N. Engl. J. Med. 2022;386:1495–1504. doi: 10.1056/NEJMoa2114833.
- Murray C.J.L., Aravkin A.Y., Zheng P., Abbafati C., Abbas K.M., Abbasi-Kangevari M., Abd-Allah F., Abdelalim A., Abdollahi M., Abdollahpour I., et al. Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020;396:1223–1249. doi: 10.1016/S0140-6736(20)30752-2.
- Manoogian E.N., Chow L.S., Taub P.R., Laferrere B., Panda S. Time-restricted eating for the prevention and management of metabolic diseases. Endocr. Rev. 2022;43:405–436. doi: 10.1210/endrev/bnab027.
- Panda S. Circadian physiology of metabolism. Science. 2016;354:1008–1015. doi: 10.1126/science.aah4967.
- Sutton E.F., Beyl R., Early K.S., Cefalu W.T., Ravussin E., Peterson C.M. Early time-restricted feeding improves Insulin Sensitivity, blood pressure, and Oxidative stress even without weight loss in men with Prediabetes. Cell Metabol. 2018;27:1212–1221.e3. doi: 10.1016/j.cmet.2018.04.010.
- Gill S., Panda S. A Smartphone App Reveals erratic Diurnal eating patterns in humans that can Be Modulated for health benefits. Cell Metabol. 2015;22:789–798. doi: 10.1016/j.cmet.2015.09.005.
- Gabel K., Hoddy K.K., Haggerty N., Song J., Kroeger C.M., Trepanowski J.F., Panda S., Varady K.A. Effects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: a pilot study. Nutr. Healthy Aging. 2018;4:345–353. doi: 10.3233/NHA-170036.
- Hatori M., Vollmers C., Zarrinpar A., DiTacchio L., Bushong E.A., Gill S., Leblanc M., Chaix A., Joens M., Fitzpatrick J.A., et al. Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell Metabol. 2012;15:848–860. doi: 10.1016/j.cmet.2012.04.019.
- Acosta-Rodriguez V., Rijo-Ferreira F., Izumo M., Xu P., Wight-Carter M., Green C.B., Takahashi J.S. Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice. Science. 2022 doi: 10.1126/science.abk0297.
- Wilkinson M.J., Manoogian E.N.C., Zadourian A., Lo H., Fakhouri S., Shoghi A., Wang X., Fleischer J.G., Navlakha S., Panda S., Taub P.R. Ten-hour time-restricted eating reduces weight, blood pressure, and atherogenic lipids in patients with metabolic syndrome. Cell Metabol. 2020;31:92–104.e5. doi: 10.1016/j.cmet.2019.11.004.
Source: PubMed