Femilis(®) 60 Levonorgestrel-Releasing Intrauterine System-A Review of 10 Years of Clinical Experience

Abstract

Objective: The aim of this study was to update the clinical experience with the Femilis® 60 levonorgestrel-releasing intrauterine system (LNG-IUS), now up to 10 years in parous and nulliparous women, particularly with regard to ease and safety of insertion, contraceptive performance, retention, acceptability, continuation of use, impact on menstrual blood loss (MBL), and duration of action.

Study design: Using the Femilis® 60 LNG-IUS releasing 20 µg of levonorgestrel/day, the following studies were conducted: an open, prospective noncomparative contraceptive study, an MBL study, a perimenopausal study, a study for the treatment of endometrial hyperplasia, and early cancer of the uterus, a residue study.

Results: A total of 599 Femilis LNG-IUS were inserted in various clinical trials, the majority for contraceptive purposes. The total exposure in the first and second contraceptive studies, covering 558 parous and nulliparous women, was 32,717 woman-months. Femilis has high contraceptive effectiveness as only one pregnancy occurred. Expulsion of the LNG-IUS was rare with only two total and no partial expulsions (stem protruding through the cervical canal) occurred. Femilis was well tolerated, with continuation rates remaining high. Several MBL studies were conducted, totaling 80 heavy and normal menstrual bleeders, using the pictorial bleeding assessment chart method or the quantitative alkaline hematin technique. Virtually all women responded well with strongly reduced menstrual bleeding. Amenorrhea rates were high, up to 80% after three months, and ferritin levels simultaneously increased significantly. The Femilis LNG-IUS was tested in 104 symptomatic perimenopausal women for seamless transition to and through menopause, adding estrogen therapy when required. Patient tolerability appeared high as >80% requested a second and a third LNG-IUS. Twenty women presenting with nonatypical and atypical hyperplasia and one woman presenting with early endometrial carcinoma were treated with Femilis LNG-IUS. All histology specimens showed full regression, and patients remained in remission without signs of hyperplasia or cancer at yearly and ongoing follow-up examinations up to 10 years. Residual content of LNG was measured in 37 women having the Femilis LNG-IUS for up to 10 years. In 10 of the 102 women who had the Femilis 60 in situ for 10 years between 20% and 30% of the original 60 mg was recovered confirming the long duration of action of the Femilis 60 LNG-IUS.

Conclusion: These studies suggest that the Femilis 60 LNG-IUS releasing 20 µg of LNG/day is an effective, well-tolerated, and well-retained contraceptive both in parous and in nulliparous women. The design of the LNG-IUS, with flexible transverse arm(s) length of 28 mm, allows for a simplification of the insertion technique and training requirements facilitating the use by nonspecialist providers in either developed or developing countries. For nulliparous women, additional evaluation of devices with a 24 mm transverse arm(s), as it relates to tolerability, retention, and continuation of use, still needs to be undertaken.

Keywords: T-shaped intrauterine system; contraception; endometrial cancer; heavy menstrual bleeding; hormone replacement therapy; hyperplasia; levonorgestrel.

Figures

Figure 1

Femilis® LNG-IUS with drug delivery rod functioning as the stem of the IUS and horizontal transverse arms.

Figure 2

Simplified push-in insertion procedure of the Femilis LNG-IUS. Step 1: The loaded inserter is applied against the cervix. Step 2: Femilis is pushed into the uterine cavity up to the fundus. Step 3: The inserter tube is removed and the thread is trimmed. The proper positioning of the LNG-IUS in the uterine cavity is easily assessed by means of abdominal or vaginal ultrasound examination.

Figure 3

Fibroplant® LNG-IUS is frameless and anchored in the fundus uteri with a nonbiodegradable surgical knot, which is pushed into the myometrium over a controlled depth using a specially designed inserter. Due to the absence of a frame, Fibroplant fits in the cavities of every size and shape.

Figure 4

(A) Mirena LNG-IUS uses a different technique than the insertion technique of Femilis. When the LNG-IUS is pushed up against a narrow fundus, the arms may be forced in the fallopian tubes or in the muscular wall. (B) Hysteroscopic example of embedment of both arms in the cornea of the uterus.