Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor

G Conn, M L Bayne, D D Soderman, P W Kwok, K A Sullivan, T M Palisi, D A Hope, K A Thomas, G Conn, M L Bayne, D D Soderman, P W Kwok, K A Sullivan, T M Palisi, D A Hope, K A Thomas

Abstract

Glioma-derived vascular endothelial cell growth factor (GD-VEGF) is a 46-kDa dimeric glycoprotein mitogen with apparently greater specificity for vascular endothelial cells than the well-characterized fibroblast growth factors. The GD-VEGF cDNA sequence encodes a 190-amino acid residue subunit that is converted, by removal of an amino-terminal hydrophobic secretory leader sequence, to the mature 164-residue subunit characterized by direct amino acid sequencing. The GD-VEGF homodimeric subunit is homologous to the platelet-derived growth factor A and B chains and its oncogene homologue v-sis.

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