BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
P Schneider, F MacKay, V Steiner, K Hofmann, J L Bodmer, N Holler, C Ambrose, P Lawton, S Bixler, H Acha-Orbea, D Valmori, P Romero, C Werner-Favre, R H Zubler, J L Browning, J Tschopp, P Schneider, F MacKay, V Steiner, K Hofmann, J L Bodmer, N Holler, C Ambrose, P Lawton, S Bixler, H Acha-Orbea, D Valmori, P Romero, C Werner-Favre, R H Zubler, J L Browning, J Tschopp
Abstract
Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family, designated BAFF (for B cell activating factor belonging to the TNF family), which is expressed by T cells and dendritic cells. Human BAFF was mapped to chromosome 13q32-34. Membrane-bound BAFF was processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. The expression of BAFF receptor appeared to be restricted to B cells. Both membrane-bound and soluble BAFF induced proliferation of anti-immunoglobulin M-stimulated peripheral blood B lymphocytes. Moreover, increased amounts of immunoglobulins were found in supernatants of germinal center-like B cells costimulated with BAFF. These results suggest that BAFF plays an important role as costimulator of B cell proliferation and function.
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References
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Source: PubMed