Unknown unknowns - COVID-19 and potential global mortality
Victor Grech, Victor Grech
Abstract
COVID-19 (SARS-CoV-2) is currently a global pandemic. This paper will attempt to estimate global infection rates and potential resultant mortality in the absence of effective treatment and/or vaccination. Calculations are based on World Health Organisation data from Wuhan in China: 14% of infected cases are severe, 5% require intensive care and 4% die. Estimated infection rates and mortality rates at the level of continents and some individual countries (when these are of sufficient size) are tabulated. This pandemic may cause close to half a billion deaths, i.e. 6% of the global population - and potentially more. At the risk of sounding sensational, but with a sober sense of realism, healthcare risks being plunged into the Middle-Ages if the public do not do their part. Infection cannot occur in the absence of contact. The only way to mitigate these numbers is to apply social distancing and take the standard precautions so frequently reiterated by Public Health: hand washing, avoid touching the face and so on. These measures are crucial as the human cost is going to be unthinkable even in the best-case scenarios that epidemiologists are modelling.
Copyright © 2020 Elsevier B.V. All rights reserved.
References
- Juvenal. Satires vol. 6.165.
- Nassim Taleb. Penguin; London: 2013. Antifragile: Things that Gain from Disorder.
- Knight Frank Hyneman. Houghton-Mifflin Co; New York: 1921. Risk, Uncertainty and Profit. (reprinted University of Chicago Press, 1971)
- Yin Y., Wunderink R.G. MERS, SARS and other coronaviruses as causes of pneumonia. Respirology. 2018;23(2):130–137. doi: 10.1111/resp.13196.
- Chen N., Zhou M., Dong X. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507–513. doi: 10.1016/S0140-6736(20)30211-7.
- Fehr A.R., Perlman S. Coronaviruses: an overview of their replication and pathogenesis. Methods Mol. Biol. 2015;1282:1–23. doi: 10.1007/978-1-4939-2438-7_1.
- Ding Q., Lu P., Fan Y., Xia Y., Liu M. The clinical characteristics of pneumonia patients co-infected with 2019 novel coronavirus and influenza virus in Wuhan, China [published online ahead of print, 2020 Mar 20] J. Med. Virol. 2020 doi: 10.1002/jmv.25781. (doi:10.1002/jmv.25781)
- Velavan T.P., Meyer C.G. The COVID-19 epidemic. Tropical Med. Int. Health. 2020;25(3):278–280. doi: 10.1111/tmi.13383.
- World Health Organisation . 01 March 2020. Coronavirus Disease 2019. WHO Report 41.
- Remuzzi A., Remuzzi G. COVID-19 and Italy: what next? [published online ahead of print, 2020 Mar 13] Lancet. 2020 doi: 10.1016/S0140-6736(20)30627-9. S0140-6736 (20)30627-9.
- Neyman G., Irvin C.B. A single ventilator for multiple simulated patients to meet disaster surge. Acad. Emerg. Med. 2006;13(11):1246–1249. doi: 10.1197/j.aem.2006.05.009.
- Ferguson N.M., Laydon D., Nedjati-Gilani G., Imai N., Ainslie K., Baguelin M., Bhatia S., Boonyasiri A., Cucunubá Z., Cuomo-Dannenburg G., Dighe A. Imperial College; 2020. Impact of Non-pharmaceutical Interventions (NPIs) to Reduce COVID-19 Mortality and Healthcare Demand. March.
- Ayebare R.R., Flick R., Okware S., Bodo B., Lamorde M. Adoption of COVID-19 triage strategies for low-income settings [published online ahead of print, 2020 Mar 11] Lancet Respir. Med. 2020;S2213-2600(20):30114. doi: 10.1016/S2213-2600(20)30114-4.
- McEuen P.L. Science fiction: a post-pandemic wilderness. Nature. 2013;500(7463):398. Aug 21.
- Ayittey F.K., Ayittey M.K., Chiwero N.B., Kamasah J.S., Dzuvor C. Economic impacts of Wuhan 2019-nCoV on China and the world. J. Med. Virol. 2020;92(5):473–475. doi: 10.1002/jmv.25706.
Source: PubMed