Sorafenib Therapy Is Associated with Improved Outcomes for FMS-like Tyrosine Kinase 3 Internal Tandem Duplication Acute Myeloid Leukemia Relapsing after Allogeneic Hematopoietic Stem Cell Transplantation
Li Xuan, Yu Wang, Jia Chen, Erlie Jiang, Li Gao, Bingyi Wu, Lan Deng, Xinquan Liang, Fen Huang, Zhiping Fan, Xiaowen Tang, Jing Sun, Xi Zhang, Mingzhe Han, Depei Wu, Xiaojun Huang, Qifa Liu, Li Xuan, Yu Wang, Jia Chen, Erlie Jiang, Li Gao, Bingyi Wu, Lan Deng, Xinquan Liang, Fen Huang, Zhiping Fan, Xiaowen Tang, Jing Sun, Xi Zhang, Mingzhe Han, Depei Wu, Xiaojun Huang, Qifa Liu
Abstract
The optimal therapy for patients with acute myeloid leukemia (AML) with FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) who relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains unclear. In this study we retrospectively evaluated the efficacy of sorafenib combined with other therapeutic strategies as salvage therapy for these patients. Eighty-three AML patients with FLT3-ITD relapsing after allo-HSCT were enrolled in this study. Fifty-three patients received salvage therapy containing sorafenib and 30 patients did not. Salvage therapy containing sorafenib was superior to that without sorafenib with respect to complete remission rates, overall survival (OS), and progression-free survival (PFS) (66.0% versus 30.0%, 46.8% versus 20.0%, and 44.9% versus 16.7%, respectively; P = .002, P = .003, and P = .001). Further subgroup analysis revealed that the OS and PFS of patients who received sorafenib combined with chemotherapy followed by donor lymphocyte infusion (DLI) were superior to those receiving other therapeutic regimens, including sorafenib combined with chemotherapy, chemotherapy followed by DLI, and monochemotherapy (P = .003, P < .001). Multivariate analysis revealed that salvage therapy including sorafenib was the only protective factor for longer OS (P = .035; hazard ratio [HR], .526); salvage therapy including sorafenib and DLI were the protective factors for longer PFS (P = .011, HR, .423; P = .019, HR, .508). Our data suggest that sorafenib therapy is associated with improved outcomes for FLT3-ITD AML relapsing after allo-HSCT, and whether sorafenib combined with chemotherapy followed by DLI reveals an optimal efficacy merits further study.
Keywords: Acute myeloid leukemia; Allogeneic hematopoietic stem cell transplantation; FMS-like tyrosine kinase 3 internal tandem duplication; Relapse; Sorafenib.
Copyright © 2019 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.
Source: PubMed