Black cumin (Nigella sativa) and its constituent (thymoquinone): a review on antimicrobial effects

Fatemeh Forouzanfar, Bibi Sedigheh Fazly Bazzaz, Hossein Hosseinzadeh, Fatemeh Forouzanfar, Bibi Sedigheh Fazly Bazzaz, Hossein Hosseinzadeh

Abstract

Nigella sativa seeds have wide therapeutic effects and have been reported to have significant effects against many ailments such as skin diseases, jaundice, gastrointestinal problems, anorexia, conjunctivitis, dyspepsia, rheumatism, diabetes, hypertension, intrinsic hemorrhage, paralysis, amenorrhea, anorexia, asthma, cough, bronchitis, headache, fever, influenza and eczema. Thymoquinone (TQ) is one of the most active constituent and has different beneficial properties. Focus on antimicrobial effects, different extracts of N. sativa as well as TQ, have a broad antimicrobial spectrum including Gram-negative, Gram-positive bacteria, viruses, parasites, schistosoma and fungi. The effectiveness of N. sativa seeds and TQ is variable and depends on species of target microorganisms. The present review paper tries to describe all antimicrobial activities that have been carried out by various researchers.

Keywords: Antifungal; Antimicrobial; Antiparasite; Antischistosoma; Antivirus; Nigella sativa; Thymoquinone Antibacterial.

Figures

Figure 1
Figure 1
Different effects of Nigella sativa against microorganisms

References

    1. Goreja WG. New York, NY: Amazing Herbs Press; 2003. Black seed: nature's miracle remedy.
    1. Khan MR. Chemical composition and medicinal properties of Nigella sativa Linn. Inflammo-pharmacology. 1999;7:13–35.
    1. Tembhurne SV, Feroz S, Sakarkar DM. A review on therapeutic potential of Nigella sativa (kalonji) seeds. J Med Plants Res. 2014;8:166–167.
    1. Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, et al. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac J Trop Biomed. 2013;3:337–352.
    1. Staphylakis PK, Gegiou D. The sterols of Nigella sativa seed oil. Phytochemistry. 1986;25:761–763.
    1. Enomoto S, Asano R, Iwahori Y, Narui T, Okada Y, Singab AN, et al. Hematological studies on black cumin oil from the seeds of Nigella sativa L. Biol Pharm Bull. 2001;24:307–310.
    1. Haq A, Lobo I, Al-Tufail M, Rama NR, Sedairy ST. Immunomodulatory effect of Nigella sativa proteins fractionated by ion exchange chromatography. Int J Immunopharmacol. 1999;21:283–285.
    1. Parvardeh S, Nassiri-Asl M, Mansouri MT, Hosseinzadeh H. Study on the anticonvulsant activity of thymoquinone, the major constituent of Nigella sativa L. seeds, through intracerebroventricular injection. J Med Plants. 2005;4:45–52.
    1. Hosseinzadeh H, Parvardeh S. Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice. Phytomedicine. 2004;11:56–64.
    1. Hosseinzadeh H, Parvardeh S, Nassiri-Asl M, Mansouri MT. Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. Med Sci Monit. 2005;11:BR106–BR110.
    1. Hosseinzadeh H, Taiari S, Nassiri-Asl M. Effect of thymoquinone, a constituent of Nigella sativa L. on ischemia-reperfusion in rat skeletal muscle. N-S Arch Pharmacol. 2012;385:503–508.
    1. El Gazzar M, El Mezayen R, Marecki JC, Nicolls MR, Canastar A, Dreskin SC. Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation. Int Immunopharmacol. 2006;6:1135–1142.
    1. Gali-Muhtasib H, Ocker M, Kuester D, Krueger S, El-Hajj Z, Diestel A, et al. Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models. J Cell Mol Med. 2008;12:330–342.
    1. Halawani E. Antibacterial activity of thymo-quinone and thymohydroquinone of Nigella sativa L. and their interaction with some antibiotics. Adv Biol Res. 2009;3:148–152.
    1. Abdel Azeiz AZ, Saad AH, Darweesh MF. Efficacy of thymoquinone against vaginal candidiasis in prednisolone-induced immunosuppressed mice. J Am Sci. 2013;9:155–159.
    1. Phillips JD. Medicinal plants. Biologist. 1992;39:187–191.
    1. Sayed MD. Traditional medicine in health care, J. Ethnopharmacol. 1980;2:19–22.
    1. Burits M, Bucar F. Antioxidant activity of Nigella sativa essential oil. Phytother Res. 2000;14:323–328.
    1. Rajsekhar S, Kuldeep B. Pharmacognosy and pharmacology of Nigella sativa. J Pharm Res. 2011;2:36–39.
    1. Merfort I, Wray V, Barakat HH, Hussein SAM, Nawwar MAM, Willuhn G. Flavonoid triglycerides from seeds of Nigella sativa. Phytochemistry. 1997;46:359–363.
    1. Aboutabl EA, El-Azzouny AA, Hammerschmidt FJ. Berlin, New York: Walter de Gruyter and Co; 1986. Aroma volatiles of Nigella sativa L. seeds. Progress in Essential Oil Research; pp. 49–55.
    1. Warrier PK, Nambiar VPK, Ramankutty C, Vasudevan Nair R. Telangana: Orient Longman; 2004. Indian Medicinal Plants: A Compendium of 500 Species; pp. 139–142.
    1. New Delhi: 1989. The Ayurvedic Pharmacopoeia of India, part 1, Ministry of Health and Family Welfare; pp. 119–120.
    1. Hosseinzadeh H, Moghim FF, Mansouri SMT. Effect of Nigella sativa seed extracts on ischemia-reperfusion in rat skeletal muscle. Pharmacologyonline. 2007;2:326–335.
    1. Hosseinzadeh H, Eskandari M, Ziaee T. Anti-tussive effect of thymoquinone a constituent of Nigella Sativa Seeds in guinea pigs. Pharmacology online. 2008;2:480–484.
    1. El-Abhar HS, Abdallah DM, Saleh S. Gastroprotective effect of black seed. J Ethnopharmacol. 2003;84:251–258.
    1. Bin Sayeed MS, Shams T, Fahim Hossain S, Rahman MR, Mostofa A, Fahim Kadir M, et al. Nigella sativa L. seeds modulate mood, anxiety and cognition in healthy adolescent males. J Ethnopharmacol. 2014;152:156–162.
    1. Rajkapoor B, Anandan R, Jayakar B. Anti-ulcer effect of Nigella sativa Linn against gastric ulcers in rats. Curr Sci. 2002;82:177–179.
    1. Boskabady MH, Mohsenpoor N, Takaloo L. Anti asthmatic effect of Nigella sativa in airways of asthmatic patients. Phytomedicine. 2010;17:707–713.
    1. Shafi G, Munshi A, Hasan TN, Alshatwi AA, Jyothy A, David KY. Anti cancer activity of Nigella sativa. Cancer Cell Int. 2009;9:29.
    1. Salem ML. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol. 2005;5:1749–1770.
    1. Majdalawieh AF, Hmaidan R, Carr RI. Nigella sativa modulates splenocyte proliferation, Th1/Th2 cytokine profile, macrophage function and NK anti-tumor activity. J Ethnopharmacol. 2010;131:268–275.
    1. Khan MR. Chemical composition and medicinal properties of Nigella sativa Linn. Inflammopharmacology. 1999;7:13–35.
    1. Bukhari MH, Khalil J, Qamar S, Qamar Z, Zahid M, Ansari N, et al. Comparative gastroprotective effects of natural honey Nigella sativa and cimetidine against acetylsalicylic acid induced gastric ulcer in albino rats. J Coll Physicians Surg Pak. 2011;21:151–156.
    1. Salim EI. Cancer chemopreventive potential of volatile oil from black cumin seeds, Nigella sativa L. in a rat multi-organ carcinogenesis bioassay. Oncol Lett. 2010;1:913–924.
    1. Kolahdooz M, Nasri S, Modarres SZ, Kianbakht S, Huseini HF. Effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men: A randomized, double-blind, placebo-controlled clinical trial. Phytomedicine. 2014;21:901–905.
    1. Sultan MT, Butt MS, Anjum FM, Jamil A. Influence of black cumin fixed and essential oil supplementation on markers of myocardial necrosis in normal and diabetic rats. Pak J Nutr. 2009;8:1450–1455.
    1. Hosseini M, Mohammadpour T, Karami R, Rajaei Z, Sadeghnia HR, Soukhtanloo M. Effects of the hydro-alcoholic extract of Nigella sativa on scopolamine-induced spatial memory impairment in rats and its possible mechanism. Chin J Integr Med. 2014:1–7.
    1. Hosseinzadeh H, Tafaghodi M, Mosavi MJ, Taghiabadi E. Effect of aqueous and ethanolic extracts of Nigella sativa seeds on milk production in rats. J Acupunct Meridian Stud. 2013;6:18–23.
    1. Hosseinzadeh H, Parvardeh S, Asl MN, Sadeghnia HR, Ziaee T. Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus. Phytomedicine. 2007;14:621–627.
    1. Hosseinzadeh H, Fazly Bazzaz BS, Motevaly Haghi M. Antibacterial activity of total extracts and essential oil of Nigella sativa L. seeds in mice. Pharmacol online. 2007;2:429–435.
    1. Aljabre SH, Randhawa MA, Akhtar N, Alakloby OM, Alqurashi AM, Aldossary A. Antidermatophyte activity of ether extract of Nigella sativa and its active principle, thymoquinone. J Ethnopharm. 2005;101:116–119.
    1. Salem ML, Hossain MS. Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection. Int J Immunopharmacol. 2000;22:729–740.
    1. Dorman HJ, Deans SG. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol. 2000;88:308–316.
    1. Morsi NM. Antimicrobial effect of crude extracts of Nigella sativa on multiple antibiotics-resistant bacteria. Acta Microbiol Pol. 2000;49:63–74.
    1. Hannan A, Saleem S, Chaudhary S, Barkaat M, Arshad MU. Anti-bacterial activity of Nigella sativa against clinical isolates of methicillin resistant Staphylococcus aureus. J Ayub Med Coll Abbottabad. 2008;20:72–74.
    1. Bakathir HA, Abbas NA. Detection of the antibacterial effect of Nigella sativa ground seeds with water. Afr J Tradit Compl Altern Med. 2011;8:159–164.
    1. Monika T, Sasikala P, Vijaya Bhaskara Reddy M. A investigational of antibacterial activities of Nigella sativa on mastaitis in dairy crossbred cows. Int J Adv Technical Res. 2013;3:263–272.
    1. Hanafy MS, Hatem ME. Studies on the antimicrobial activity of Nigella sativa seed (black cumin) J Ethnopharmacol. 1991;34:275–278.
    1. Nair MKM, Vasudevan P, Venkitanarayanan K. Antibacterial effect of black seed oil on Listeria monocytogenes. Food Cont. 2005;16:395–398.
    1. Chaieb K, Kouidhi B, Jrah H, Mahdouani K, Bakhrouf A. Antibacterial activity of Thymoquinone, an active principle of Nigella sativa and its potency to prevent bacterial biofilm formation. BMC Complement Altern Med. 2011;11:1–6.
    1. Harzallah HJ, Kouidhi B, Flamini G, Bakhrouf A, Mahjoub T. Chemical composition, antimicrobial potential against cariogenic bacteria and cytotoxic activity of Tunisian Nigella sativa essential oil and thymoquinone. Food Chem. 2011;129:1469–1474.
    1. Hasan NA, Nawahwi MZ, Malek HA. Anti microbial activity of Nigella sativa seed extract. Sains Malaysiana. 2013;42:143–147.
    1. Deepak SS, Sikender M, Garg V, Samim M. Entrapment of seed extract of Nigella sativa into thermosensitive (NIPAAm–Co–VP) co-polymeric micelles and its antibacterial activity. Int J Pharm Sci Drug Res. 2011;3:246–252.
    1. Evirgen O, Gokçe A, Ozturk OH, Nacar E, Onlen Y, Ozer B, et al. Effect of thymoquinone on oxidative stress in Escherichia coli-Induced Pyelonephritis in Rats. Curr Ther Res Clin Exp. 2011;72:204–215.
    1. Rogozhin EA, Oshchepkova YI, Odintsova TI, Khadeeva NV, Veshkurova ON, Egorov TA, et al. Novel antifungal defensins from Nigella sativa L. seeds. Plant Physiol Biochem. 2011;49:131–137.
    1. El-Nagerabia SA, Al-Bahryb SN, Elshafieb AE, AlHilalib S. Effect of Hibiscus sabdariffa extract and Nigella sativa oil on the growth and aflatoxin B1 production of Aspergillus flavus and Aspergillus parasiticus strains. Food Cont. 2012;25:59–63.
    1. Sunita M, Meenakshi SH. Chemical composition and antidermatophytic activity of Nigella sativa essential oil. Afr J Pharm Pharacol. 2013;7:1286–1292.
    1. Fierro IM, Barja-Fidalgo C, Cunha FQ, Ferreira SH. The involvement of nitric oxide in the anti-Candida albicans activity of rat neutrophils. Immunology. 1996;89:295–300.
    1. Khan MA, Ashfaq MK, Zuberi HS, Mahmood MS, Gilani AH. The in vivo antifungal activity of the aqueous extract from Nigella sativa seeds. Phytother Res. 2003;17:183–186.
    1. Bita A, Rosu AF, Calina D, Rosu L, Zlatian O, Dindere C, et al. An alternative treatment for Candida infections with Nigella sativa extracts. Eur J Hosp Pharm. 2012;19:162.
    1. Mahmoud MR, El-Abhar HS, Saleh S. The effect of Nigella sativa oil against the liver damage induced by Schistosoma mansoni infection in mice. J Ethnopharmacol. 2002;79:1–11.
    1. Aboul-Ela EI. Cytogenetic studies on Nigella sativa seeds extract and thymoquinone on mouse cells infected with schistosomiasis using karyotyping. Mutat Res. 2002;516:11–17.
    1. Mohamed AM, Metwally NM, Mahmoud SS. Sativa seeds against Schistosoma mansoni different stages. Mem Inst Oswaldo Cruz. 2005;100:05–211.
    1. Shenawy El Nahla S, Soliman MF, Reyad SI. The effect of antioxidant properties of aqueous garlic extract and Nigella sativa as anti- schistosomiasis agents in mice. Rev Inst Med Trop Sao Paulo. 2008;50:29–36.
    1. Peterhans E. Oxidants and antioxidants in viral diseases: disease mechanisms and metabolic regulation. J Nutr. 1997;127:962S–965S.
    1. Salem ML, Hossain MS. In vivo acute depletion of CD8 (+) T cells before murine cytomegalovirus infection upregulated innate antiviral activity of natural killer cells. Int J Immunopharmacol. 2000;22:707–718.
    1. Barakat EM, El Wakeel LM, Hagag RS. Effects of Nigella sativa on outcome of hepatitis C in Egypt. World J Gastroenterol. 2013;19:2529–2536.
    1. Akhtar MS, Riffat S. Field trial of Saussurea lappa roots against nematodes and Nigella sativa seeds against cestodes in children. J Pak Med Assoc. 1991;41:185–187.
    1. Okeola VO, Adaramoye OA, Nneji CM, Falade CO, Farombi EO, Ademowo OG. Antimalarial and antioxidant activities of methanolic extract of Nigella sativa seeds (black cumin) in mice infected with Plasmodium yoelli nigeriensis. Parasitol Res. 2011;108:1507–1512.
    1. Baghdadi HB, Al-Mathal EM. Anti-coccidial activity of Nigella sativa L. J Food Agricul Envir. 2011;9:10–17.

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