Cerebral Salt-wasting Syndrome and Inappropriate Antidiuretic Hormone Syndrome after Subarachnoid Hemorrhaging

Hanako Nakajima, Hiroshi Okada, Kazuki Hirose, Toru Murakami, Yayoi Shiotsu, Mayuko Kadono, Mamoru Inoue, Goji Hasegawa, Hanako Nakajima, Hiroshi Okada, Kazuki Hirose, Toru Murakami, Yayoi Shiotsu, Mayuko Kadono, Mamoru Inoue, Goji Hasegawa

Abstract

Hyponatremia is a common finding after subarachnoid hemorrhaging (SAH) and can be caused by either cerebral salt-wasting syndrome (CSWS) or syndrome of inappropriate antidiuretic hormone (SIADH). Distinguishing between these two entities can be difficult because they have similar manifestations, including hyponatremia, serum hypo-osmolality, and high urine osmolality. We herein report the case of a 60-year-old man who suffered from SAH complicated by hyponatremia. During his initial hospitalization, he was diagnosed with CSWS. He was readmitted one week later with hyponatremia and was diagnosed with SIADH. This is the first report of SAH causing CSWS followed by SIADH. These two different sources of hyponatremia require different treatments.

Figures

Table 1
Table 1
Laboratory Data during the First and Second Hospitalizations.
Figure.
Figure.
Clinical course.

References

    1. Kurokawa Y, Uede T, Ishiguro M, et al. . Pathogenesis of hyponatremia following subarachnoid hemorrhage due to ruptured cerebral aneurysm. Surg Neurol 46: 500-507, 1996.
    1. Sherlock M, O'Sullivan E, Agha A, et al. . The incidence and pathophysiology of hyponatremia after subarachnoid hemorrhage. Clin Endocrinol 64: 250-254, 2006.
    1. Hannon MJ, Behan LA, O'Brien MM, et al. . Hyponatremia following mild/moderate subarachnoid hemorrhage is due to SIAD and glucocorticoid deficiency and not cerebral salt wasting. J Clin Endocrinol Metab 99: 291-298, 2014.
    1. Marupudi NI, Mittal S. Diagnosis and management of hyponatremia in patients with aneurysmal subarachnoid hemorrhage. J Clin Med 4: 756-767, 2015.
    1. Milionis HJ, Liamis GL, Elisaf MS. The hyponatremic patient: a systematic approach to laboratory diagnosis. CMAJ 166: 1056-1062, 2002.
    1. Al-Mufti H. Hyponatremia due to cerebral salt-wasting syndrome: combined cerebral and distal tubular lesion. Am J Med 77: 740-746, 1984.
    1. Laville M, Burst V, Peri A, Verbalis JG. Hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH): therapeutic decision-making in real-life cases. Clin Kidney J 6: 1-20, 2013.
    1. Sterns RH, Silver SM. Cerebral salt wasting versus SIADH: what difference? J Am Soc Nephrol 19: 194, 2008.
    1. Kao L, Al-Lawati Z, Vavao J, Steinberg GK, Katznelson L. Prevalence and clinical demographics of cerebral salt wasting in patients with aneurysmal subarachnoid hemorrhage. Pituitary 12: 347-351, 2009.
    1. Isotani E, Suzuki R, Tomita K, et al. . Alterations in plasma concentrations of natriuretic peptides and antidiuretic hormone after subarachnoid hemorrhage. Stroke 25: 2198-2203, 1994.
    1. Smith DM, McKenna K. Hyponatraemia. Clin Endocrinol 52: 667-678, 2000.
    1. Bitew S, Imbriano L, Miyawaki N, Fishbane S, Maesaka JK. More on renal salt wasting without cerebral disease: response to saline infusion. Clin J Am Soc Nephrol 4: 309-315, 2009.
    1. Berendes E, Walter M, Cullen P, et al. . Secretion of brain natriuretic peptide in patients with aneurysmal subarachnoid haemorrhage. Lancet 349: 245-249, 1997.
    1. Fox JL, Falik JL, Schlhoub RJ. Neurosurgical hyponatremia: the role of inappropriate antidiuresis. J Neurosurg 34: 506-514, 1971.
    1. Cogan E, Debieve MF, Pepersack T, Abramow M. Natriuresis and atrial natriuretic factor secretion during inappropriate antidiuresis. Am J Med 84: 409-418, 1998.
    1. Maesaka JK, Miyawaki N, Palaia T, Fishbane S, Durham JH. Renal salt wasting without cerebral disease: diagnostic value of urate determinations in hyponatremia. Kidney Int 71: 822-826, 2007.
    1. Maesaka JK, Gupta S, Fishbane S. Cerebral salt-wasting syndrome: Does it exist? Nephron 82: 100-109, 1999.
    1. Ogasawara K, Kinouchi H, Nagamine Y. Cerebral salt wasting syndrome and SIADH. No Shinkei Geka 26: 501-505, 1998(in Japanese, Abstract in English).
    1. Cerdà-Esteve M, Cuadrado-Godia E, Chillaron JJ, et al. . Cerebral salt wasting syndrome: review. Eur J Intern Med 19: 249-254, 2008.

Source: PubMed

3
Subskrybuj