Neurocognitive and social cognitive approaches for improving functional outcome in early psychosis: theoretical considerations and current state of evidence

Cali F Bartholomeusz, Kelly Allott, Cali F Bartholomeusz, Kelly Allott

Abstract

Improving functional outcome, in addition to alleviating psychotic symptoms, is now a major treatment objective in schizophrenia research. Given the large body of evidence suggesting pharmacological treatments generally have minimal effects on indices of functioning, research has turned to psychosocial rehabilitation programs. Among these, neurocognitive and social cognitive interventions are at the forefront of this field and are argued to target core deficits inherent to the schizophrenia illness. However, to date, research trials have primarily focused on chronic schizophrenia populations, neglecting the early psychosis groups who are often as severely impaired in social and occupational functioning. This theoretical paper will outline the rationale for investigating adjunctive cognitive-based interventions in the early phases of psychotic illness, critically examine the current approach strategies used in these interventions, and assess the evidence supporting certain training programs for improving functional outcome in early psychosis. Potential pathways for future research will be discussed.

References

    1. Buchanan RW, Davis M, Goff D, et al. A summary of the FDA-NIMH-MATRICS workshop on clinical trial design for neurocognitive drugs for schizophrenia. Schizophrenia Bulletin. 2005;31(1):5–19.
    1. Harvey PD, Bellack AS. Toward a terminology for functional recovery in schizophrenia: is functional remission a viable concept? Schizophrenia Bulletin. 2009;35(2):300–306.
    1. Birchwood M, Todd P, Jackson C. Early intervention in psychosis: the critical period hypothesis. British Journal of Psychiatry. 1998;172(33):53–59.
    1. Jablensky A. Epidemiology of schizophrenia: the global burden of disease and disability. European Archives of Psychiatry and Clinical Neuroscience. 2000;250(6):274–285.
    1. Yung AR, Phillips LJ, Yuen HP, et al. Psychosis prediction: 12-Month follow up of a high-risk (“prodromal”) group. Schizophrenia Research. 2003;60(1):21–32.
    1. Menezes NM, Arenovich T, Zipursky RB. A systematic review of longitudinal outcome studies of first-episode psychosis. Psychological Medicine. 2006;36(10):1349–1362.
    1. Malla A, Payne J. First-episode psychosis: psychopathology, quality of life, and functional outcome. Schizophrenia Bulletin. 2005;31(3):650–671.
    1. Garety PA, Craig TKJ, Dunn G, et al. Specialised care for early psychosis: symptoms, social functioning and patient satisfaction—randomised controlled trial. British Journal of Psychiatry. 2006;188:37–45.
    1. Thorup A, Petersen L, Jeppesen P, et al. Integrated treatment ameliorates negative symptoms in first episode psychosis—results from the Danish OPUS trial. Schizophrenia Research. 2005;79(1):95–105.
    1. Killackey E, Yung AR. Effectiveness of early intervention in psychosis. Current Opinion in Psychiatry. 2007;20(2):121–125.
    1. McGorry PD, Edwards J, Mihalopoulos C, Harrigan SM, Jackson HJ. EPPIC: an evolving system of early detection and optimal management. Schizophrenia Bulletin. 1996;22(2):305–326.
    1. Bilder RM. The neuropsychology of schizophrenia circa 2009. Neuropsychology Review. 2009;19(3):277–279.
    1. Bartholomeusz CF, Killackey E, Thompson A, et al. Interventions targeting social and vocational dysfunction in individuals with a schizophrenia spectrum disorder. In: Ritsner M, editor. Handbook of Schizophrenia Spectrum Disorders. Vol. 3. New York, NY, USA: Springer; 2011.
    1. Couture SM, Penn DL, Roberts DL. The functional significance of social cognition in schizophrenia: a review. Schizophrenia bulletin. 2006;32:S44–S63.
    1. Blakemore SJ. Development of the social brain during adolescence. Quarterly Journal of Experimental Psychology. 2008;61(1):40–49.
    1. Paus T. Mapping brain maturation and cognitive development during adolescence. Trends in Cognitive Sciences. 2005;9(2):60–68.
    1. Gogtay N, Giedd JN, Lusk L, et al. Dynamic mapping of human cortical development during childhood through early adulthood. Proceedings of the National Academy of Sciences of the United States of America. 2004;101(21):8174–8179.
    1. Steinberg L. Cognitive and affective development in adolescence. Trends in Cognitive Sciences. 2005;9(2):69–74.
    1. Steinberg L, Morris AS. Adolescent development. Annual Review of Psychology. 2001;52:83–110.
    1. Paus T, Keshavan M, Giedd JN. Why do many psychiatric disorders emerge during adolescence? Nature Reviews Neuroscience. 2008;9(12):947–957.
    1. Australian Bureau of Statistics. National survey of mental health and wellbeing: summary of results. Sydney, Australia: Australain Bureau of Statistics,; 2007.
    1. Morgan V, Waterreus A, Jablensky A, et al. People living with psychotic illness 2010: report on the second Australian national survey. Canberra, Australia: Department of Health and Aging; 2011.
    1. Pantelis C, Yücel M, Bora E, et al. Neurobiological markers of illness onset in psychosis and schizophrenia: the search for a moving target. Neuropsychology Review. 2009;19(3):385–398.
    1. Mesholam-Gately RI, Giuliano AJ, Goff KP, Faraone SV, Seidman LJ. Neurocognition in first-episode Schizophrenia: a meta-analytic review. Neuropsychology. 2009;23(3):315–336.
    1. Dickinson D, Ragland JD, Gold JM, Gur RC. General and specific cognitive deficits in schizophrenia: Goliath defeats David? Biological Psychiatry. 2008;64(9):823–827.
    1. Bozikas VP, Andreou C. Longitudinal studies of cognition in first episode psychosis: a systematic review of the literature. Australian and New Zealand Journal of Psychiatry. 2011;45(2):93–108.
    1. Brewer WJ, Wood SJ, Phillips LJ, et al. Generalized and specific cognitive performance in clinical high-risk cohorts: a review highlighting potential vulnerability markers for psychosis. Schizophrenia Bulletin. 2006;32(3):538–555.
    1. Correll CU, Hauser M, Auther AM, Cornblatt BA. Research in people with psychosis risk syndrome: a review of the current evidence and future directions. Journal of Child Psychology and Psychiatry and Allied Disciplines. 2010;51(4):390–431.
    1. Fusar-Poli P, Perez J, Broome M, et al. Neurofunctional correlates of vulnerability to psychosis: a systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews. 2007;31(4):465–484.
    1. Addington J, Saeedi H, Addington D. Facial affect recognition: a mediator between cognitive and social functioning in psychosis? Schizophrenia Research. 2006;85(1–3):142–150.
    1. Edwards J, Pattison PE, Jackson HJ, Wales RJ. Facial affect and affective prosody recognition in first-episode schizophrenia. Schizophrenia Research. 2001;48(2-3):235–253.
    1. Pinkham AE, Penn DL, Perkins DO, Graham KA, Siegel M. Emotion perception and social skill over the course of psychosis: a comparison of individuals “at-risk” for psychosis and individuals with early and chronic schizophrenia spectrum illness. Cognitive Neuropsychiatry. 2007;12(3):198–212.
    1. Amminger GP, Schafer MR, Papageorgiou K, et al. Emotion recognition in individuals at clinical high-risk for Schizophrenia. Schizophrenia Bulletin. In press.
    1. Green MF, Bearden CE, Cannon TD, et al. Social cognition in Schizophrenia, Part 1: performance across phase of illness. Schizophrenia Bulletin. In press.
    1. Bertrand MC, Sutton H, Achim AM, Malla AK, Lepage M. Social cognitive impairments in first episode psychosis. Schizophrenia Research. 2007;95(1–3):124–133.
    1. Montreuil T, Bodnar M, Bertrand MC, Malla AK, Joober R, Lepage M. Social cognitive markers of short-term clinical outcome in first-episode psychosis. Clinical Schizophrenia and Related Psychoses. 2010;4(2):105–114.
    1. Inoue Y, Yamada K, Hirano M, et al. Impairment of theory of mind in patients in remission following first episode of schizophrenia. European Archives of Psychiatry and Clinical Neuroscience. 2006;256(5):326–328.
    1. Kettle JWL, O’Brien-Simpson L, Allen NB. Impaired theory of mind in first-episode schizophrenia: comparison with community, university and depressed controls. Schizophrenia Research. 2008;99(1–3):96–102.
    1. Koelkebeck K, Pedersen A, Suslow T, Kueppers KA, Arolt V, Ohrmann P. Theory of Mind in first-episode schizophrenia patients: correlations with cognition and personality traits. Schizophrenia Research. 2010;119(1–3):115–123.
    1. Krstev H, Jackson H, Maude D. An investigation of attributional style in first-episode psychosis. British Journal of Clinical Psychology. 1999;38(2):181–194.
    1. An SK, Kang JI, Park JY, Kim KR, Lee SY, Lee E. Attribution bias in ultra-high risk for psychosis and first-episode schizophrenia. Schizophrenia Research. 2010;118(1–3):54–61.
    1. Thompson AD, Bartholomeusz C, Yung AR. Social cognition deficits and the 'ultra high risk' for psychosis population: a review of literature. Early Intervention in Psychiatry. 2011;5(3):192–202.
    1. Addington J, Penn D, Woods SW, Addington D, Perkins DO. Facial affect recognition in individuals at clinical high risk for psychosis. British Journal of Psychiatry. 2008;192(1):67–68.
    1. Schloegelhofer M, Schaefer M, Papageorgiou K, et al. Emotion recognition in individuals at Ultra High Risk for psychosis. Schizophrenia Bulletin. 2006;86:S94–S95.
    1. van Rijn S, Aleman A, de Sonneville L, et al. Misattribution of facial expressions of emotion in adolescents at increased risk of psychosis: the role of inhibitory control. Psychological Medicine. 2011;41:499–508.
    1. Chung YS, Kang DH, Shin NY, Yoo SY, Kwon JS. Deficit of theory of mind in individuals at ultra-high-risk for schizophrenia. Schizophrenia Research. 2008;99(1–3):111–118.
    1. Couture SM, Penn DL, Addington J, Woods SW, Perkins DO. Assessment of social judgments and complex mental states in the early phases of psychosis. Schizophrenia Research. 2008;100(1–3):237–241.
    1. Blakemore SJ. The social brain in adolescence. Nature Reviews Neuroscience. 2008;9(4):267–277.
    1. Pantelis C, Velakoulis D, Wood SJ, et al. Neuroimaging and emerging psychotic disorders: the Melbourne ultra-high risk studies. International Review of Psychiatry. 2007;19(4):373–381.
    1. Jung WH, Jang JH, Byun MS, An SK, Kwon JS. Structural brain alterations in individuals at ultra-high risk for psychosis: a review of magnetic resonance imaging studies and future directions. Journal of Korean Medical Science. 2010;25(12):1700–1709.
    1. Seiferth NY, Pauly K, Kellermann T, et al. Neuronal correlates of facial emotion discrimination in early onset schizophrenia. Neuropsychopharmacology. 2009;34(2):477–487.
    1. Seiferth NY, Pauly K, Habel U, et al. Increased neural response related to neutral faces in individuals at risk for psychosis. NeuroImage. 2008;40(1):289–297.
    1. Brüne M, Özgürdal S, Ansorge N, et al. An fMRI study of "theory of mind" in at-risk states of psychosis: comparison with manifest schizophrenia and healthy controls. NeuroImage. 2011;55(1):329–337.
    1. Boksman K, Théberge J, Williamson P, et al. A 4.0-T fMRI study of brain connectivity during word fluency in first-episode schizophrenia. Schizophrenia Research. 2005;75(2-3):247–263.
    1. Woodward ND, Waldie B, Rogers B, Tibbo P, Seres P, Purdon SE. Abnormal prefrontal cortical activity and connectivity during response selection in first episode psychosis, chronic schizophrenia, and unaffected siblings of individuals with schizophrenia. Schizophrenia Research. 2009;109(1–3):182–190.
    1. Luck D, Buchy L, Czechowska Y, et al. Fronto-temporal disconnectivity and clinical short-term outcome in first episode psychosis: a DTI-tractography study. Journal of Psychiatric Research. 2011;45(3):369–377.
    1. Crossley NA, Mechelli A, Fusar-Poli P, et al. Superior temporal lobe dysfunction and frontotemporal dysconnectivity in subjects at risk of psychosis and in first-episode psychosis. Human Brain Mapping. 2009;30(12):4129–4137.
    1. Green MF, Kern RS, Braff DL, Mintz J. Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the “right stuff”? Schizophrenia Bulletin. 2000;26(1):119–136.
    1. Fett AKJ, Viechtbauer W, Dominguez MDG, Penn DL, van Os J, Krabbendam L. The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis. Neuroscience and Biobehavioral Reviews. 2011;35(3):573–588.
    1. Allott K, Liu P, Proffitt TM, Killackey E. Cognition at illness onset as a predictor of later functional outcome in early psychosis: systematic review and methodological critique. Schizophrenia Research. 2011;125:221–235.
    1. Bell M, Tsang HWH, Greig TC, Bryson GJ. Neurocognition, social cognition, perceived social discomfort, and vocational outcomes in schizophrenia. Schizophrenia Bulletin. 2009;35(4):738–747.
    1. Brüne M. Emotion recognition, “theory of mind,” and social behavior in schizophrenia. Psychiatry Research. 2005;133(2-3):135–147.
    1. Pinkham AE, Penn DL. Neurocognitive and social cognitive predictors of interpersonal skill in schizophrenia. Psychiatry Research. 2006;143(2-3):167–178.
    1. Allen DN, Strauss GP, Donohue B, van Kammen DP. Factor analytic support for social cognition as a separable cognitive domain in schizophrenia. Schizophrenia Research. 2007;93(1–3):325–333.
    1. Williams LM, Whitford TJ, Flynn G, et al. General and social cognition in first episode schizophrenia: identification of separable factors and prediction of functional outcome using the IntegNeuro test battery. Schizophrenia Research. 2008;99(1–3):182–191.
    1. Addington J, Girard TA, Christensen BK, Addington D. Social cognition mediates illness-related and cognitive influences on social function in patients with schizophrenia-spectrum disorders. Journal of Psychiatry and Neuroscience. 2010;35(1):49–54.
    1. Sergi MJ, Rassovsky Y, Nuechterlein KH, Green MF. Social perception as a mediator of the influence of early visual processing on functional status in schizophrenia. American Journal of Psychiatry. 2006;163(3):448–454.
    1. Vauth R, Rüsch N, Wirtz M, Corrigan PW. Does social cognition influence the relation between neurocognitive deficits and vocational functioning in schizophrenia? Psychiatry Research. 2004;128(2):155–165.
    1. Brekke J, Kay DD, Lee KS, Green MF. Biosocial pathways to functional outcome in schizophrenia. Schizophrenia Research. 2005;80(2-3):213–225.
    1. Addington J, Saeedi H, Addington D. Influence of social perception and social knowledge on cognitive and social functioning in early psychosis. British Journal of Psychiatry. 2006;189:373–378.
    1. Horan WP, Green MF, Degroot M, et al. Social cognition in Schizophrenia, Part 2: 12-month stability and prediction of functional outcome in first-episode patients. Schizophrenia Bulletin. In press.
    1. Wykes T, Huddy V, Cellard C, McGurk SR, Czobor P. A meta-analysis of cognitive remediation for schizophrenia: methodology and effect sizes. American Journal of Psychiatry. 2011;168(5):472–485.
    1. Medalia A, Choi J. Cognitive remediation in schizophrenia. Neuropsychology Review. 2009;19(3):353–364.
    1. Fisher M, Holland C, Merzenich MM, Vinogradov S. Using neuroplasticity-based auditory training to improve verbal memory in schizophrenia. American Journal of Psychiatry. 2009;166(7):805–811.
    1. McGurk SR, Twamley EW, Sitzer DI, McHugo GJ, Mueser KT. A meta-analysis of cognitive remediation in schizophrenia. American Journal of Psychiatry. 2007;164(12):1791–1802.
    1. Kurtz MM, Richardson CL. Social cognitive training for schizophrenia: a meta-analytic investigation of controlled research. Schizophrenia Bulletin. In press.
    1. Horan WP, Kern RS, Tripp C, et al. Efficacy and specificity of social cognitive skills training for outpatients with psychotic disorders. Journal of Psychiatric Research. 2011;45(8):1113–1122.
    1. Roder V, Mueller DR, Mueser KT, Brenner HD. Integrated psychological therapy (IPT) for schizophrenia: is it effective? Schizophrenia bulletin. 2006;32:S81–S93.
    1. Rauchensteiner S, Kawohl W, Ozgurdal S, et al. Test-performance after cognitive training in persons at risk mental state of schizophrenia and patients with schizophrenia. Psychiatry Research. 2011;185:334–339.
    1. McGurk SR, Mueser KT. Response to cognitive rehabilitation in older versus younger persons with severe mental illness. American Journal of Psychiatric Rehabilitation. 2008;11(1):90–105.
    1. Wykes T, Reeder C, Landau S, Matthiasson P, Haworth E, Hutchinson C. Does age matter? Effects of cognitive rehabilitation across the age span. Schizophrenia Research. 2009;113(2-3):252–258.
    1. Hogarty GE, Flesher S, Ulrich R, et al. Cognitive enhancement therapy for schizophrenia: effects of a 2-year randomized trial on cognition and behavior. Archives of General Psychiatry. 2004;61(9):866–876.
    1. Green MF. Cognitive remediation in schizophrenia: is it time yet? American Journal of Psychiatry. 1993;150(2):178–187.
    1. Fisher M, Holland C, Subramaniam K, Vinogradov S. Neuroplasticity-based cognitive training in schizophrenia: an interim report on the effects 6 months later. Schizophrenia Bulletin. 2010;36(4):869–879.
    1. Medalia A, Freilich B. The Neuropsychological Educational Approach to Cognitive Remediation (NEAR) model: practice principles and outcome studies. American Journal of Psychiatric Rehabilitation. 2008;11(2):123–143.
    1. Twamley EW, Jeste DV, Bellack AS. A review of cognitive training in schizophrenia. Schizophrenia Bulletin. 2003;29(2):359–382.
    1. Wykes T, Reeder C. Cognitive Remediation Therapy for Schizophrenia: Theory and Practice. London, UK: Routledge; 2005.
    1. Delahunty A, Morice R. A training programme for the remediation of cognitive deficits in schizophrenia. Albury, Australia: Department of Health; 1993.
    1. Twamley EW, Savla GN, Zurhellen CH, Heaton RK, Jeste DV. Development and pilot testing of a novel compensatory cognitive training intervention for people with psychosis. American Journal of Psychiatric Rehabilitation. 2008;11(2):144–163.
    1. Pijnenborg GHM, Withaar FK, Evans JJ, Van Den Bosch RJ, Brouwer WH. SMS text messages as a prosthetic aid in the cognitive rehabilitation of schizophrenia. Rehabilitation Psychology. 2007;52(2):236–240.
    1. Velligan DI, Bow-Thomas CC, Huntzinger C, et al. Randomized controlled trial of the use of compensatory strategies to enhance adaptive functioning in outpatients with schizophrenia. American Journal of Psychiatry. 2000;157(8):1317–1323.
    1. Bellack AS, Gold JM, Buchanan RW. Cognitive rehabilitation for schizophrenia: problems, prospects, and strategies. Schizophrenia Bulletin. 1999;25(2):257–274.
    1. Velligan DI, Ritch JL, Maples NJ. Cognitive Adaptation Training: The Use of Compensatory Strategies in the Psychosocial Rehabilitation of Patients with Schizophrenia. 2nd edition. San Antonio, Tex, USA: UTHSC, Department of Psychiatry; 2010.
    1. Twamley EW, Burton CZ, Vella L. Compensatory cognitive training for psychosis: who benefits? who stays in treatment? Schizophrenia Bulletin. 2011;37(supplement 2):S55–S62.
    1. Velligan DI, Kern RS, Gold JM. Cognitive rehabilitation for schizophrenia and the putative role of motivation and expectancies. Schizophrenia Bulletin. 2006;32(3):474–485.
    1. Kern RS, Green MF, Mintz J, Liberman RP. Does “errorless learning” compensate for neurocognitive impairments in the work rehabilitation of persons with schizophrenia? Psychological Medicine. 2003;33(3):433–442.
    1. Pope JW, Kern RS. An "errorful" learning deficit in schizophrenia? Journal of Clinical and Experimental Neuropsychology. 2006;28(1):101–110.
    1. O’Carroll RE, Russell HH, Lawrie SM, Johnstone EC. Errorless learning and the cognitive rehabilitation of memory-impaired schizophrenic patients. Psychological Medicine. 1999;29(1):105–112.
    1. Kern RS, Green MF, Mitchell S, Kopelowicz A, Mintz J, Liberman RP. Extensions of errorless learning for social problem-solving deficits in schizophrenia. American Journal of Psychiatry. 2005;162(3):513–519.
    1. Kern RS, Liberman RP, Becker DR, Drake RE, Sugar CA, Green MF. Errorless learning for training individuals with schizophrenia at a community mental health setting providing work experience. Schizophrenia Bulletin. 2009;35(4):807–815.
    1. Silverstein SM. Bridging the gap between extrinsic and intrinsic motivation in the cognitive remediation of schizophrenia. Schizophrenia Bulletin. 2010;36(5):949–956.
    1. Krabbendam L, Aleman A. Cognitive rehabilitation in schizophrenia: a quantitative analysis of controlled studies. Psychopharmacology. 2003;169(3-4):376–382.
    1. Bell M, Bryson G, Greig T, Corcoran C, Wexler BE. Neurocognitive enhancement therapy with work therapy: effects on neuropsychological test performance. Archives of General Psychiatry. 2001;58(8):763–768.
    1. McGurk SR, Mueser KT, Pascaris A. Cognitive training and supported employment for persons with severe mental illness: one-year results from a randomized controlled trial. Schizophrenia Bulletin. 2005;31(4):898–909.
    1. Silverstein SM, Spaulding WD, Menditto AA, et al. Attention shaping: a reward-based learning method to enhance skills training outcomes in schizophrenia. Schizophrenia Bulletin. 2009;35(1):222–232.
    1. Wykes T, Reeder C, Williams C, Corner J, Rice C, Everitt B. Are the effects of cognitive remediation therapy (CRT) durable? Results from an exploratory trial in schizophrenia. Schizophrenia Research. 2003;61(2-3):163–174.
    1. Davis LW, Lysaker PH. Cognitive behavioral therapy and functional and metacognitive outcomes in schizophrenia: a single case study. Cognitive and Behavioral Practice. 2005;12(4):468–478.
    1. Moritz S, Burlon M, Woodward TS. Metacognitive Skills Training for Patients with Schizophrenia (MCT). Version 3.2. Hamburg, Germany: VanHam Campus Press; 2005.
    1. Koren D, Seidman LJ, Goldsmith M, Harvey PD. Real-world cognitive—and metacognitive—dysfunction in schizophrenia: a new approach for measuring (and remediating) more ‘right stuff’. Schizophrenia Bulletin. 2006;32(2):310–326.
    1. Bellack AS, Brown CH, Thomas-Lohrman S. Psychometric characteristics of role-play assessments of social skill in schizophrenia. Behavior Therapy. 2006;37(4):339–352.
    1. Combs DR, Adams SD, Penn DL, Roberts D, Tiegreen J, Stem P. Social Cognition and Interaction Training (SCIT) for inpatients with schizophrenia spectrum disorders: preliminary findings. Schizophrenia Research. 2007;91(1–3):112–116.
    1. Carr L, Iacoboni M, Dubeaut MC, Mazziotta JC, Lenzi GL. Neural mechanisms of empathy in humans: a relay from neural systems for imitation to limbic areas. Proceedings of the National Academy of Sciences of the United States of America. 2003;100(9):5497–5502.
    1. Oberman LM, Ramachandran VS. The simulating social mind: the role of the mirror neuron system and simulation in the social and communicative deficits of autism spectrum disorders. Psychological Bulletin. 2007;133(2):310–327.
    1. Singh JS, Hope DA. Cognitive-behavioral approaches to the treatment of social anxiety disorder. Israel Journal of Psychiatry and Related Sciences. 2009;46(1):62–69.
    1. Wolpe J. The Practice of Behaviour Therapy. 2nd edition. New York, NY, USA: Pergamon; 1969.
    1. Ponniah K, Hollon SD. Empirically supported psychological interventions for social phobia in adults: a qualitative review of randomized controlled trials. Psychological Medicine. 2008;38(1):3–14.
    1. Ponniah K, Hollon SD. Empirically supported psychological interventions for social phobia in adults: a qualitative review of randomized controlled trials. Psychological Medicine. 2008;38(1):3–14.
    1. Roberts D, Penn D, Combs D. Social Cognition and Interaction Training (SCIT) Treatment Manual. 2010.
    1. Hogarty GE, Greenwald DP. Cognitive Enhancement Therapy: The Training Manual. Pittsburgh, Pa, USA: University of Pittsburgh Medical Center; 2006.
    1. Vinogradov S, Loewy R, Fisher M, et al. Neuroplasticity-based cognitive training in early psychosis (Abstract) Biological Psychiatry. 2010;67:S188–S189.
    1. Lin A, Wood SJ, Nelson B, et al. Neurocognitive predictors of functional outcome two to 13 years after identification as ultra-high risk for psychosis. Schizophrenia Research. 2011;132(1):1–7.
    1. Niendam TA, Bearden CE, Johnson JK, et al. Neurocognitive performance and functional disability in the psychosis prodrome. Schizophrenia Research. 2006;84(1):100–111.
    1. Ueland T, Rund BR. A controlled randomized treatment study: the effects of a cognitive remediation program on adolescents with early onset psychosis. Acta Psychiatrica Scandinavica. 2004;109(1):70–74.
    1. Ueland T, Rund BR. Cognitive remediation for adolescents with early onset psychosis: a 1-year follow-up study. Acta Psychiatrica Scandinavica. 2005;111(3):193–201.
    1. Wykes T, Newton E, Landau S, Rice C, Thompson N, Frangou S. Cognitive remediation therapy (CRT) for young early onset patients with schizophrenia: an exploratory randomized controlled trial. Schizophrenia Research. 2007;94(1–3):221–230.
    1. Eack SM, Greenwald DP, Hogarty SS, et al. Cognitive enhancement therapy for early-course schizophrenia: effects of a two-year randomized controlled trial. Psychiatric Services. 2009;60(11):1468–1476.
    1. Eack SM, Hogarty GE, Greenwald DP, Hogarty SS, Keshavan MS. Effects of cognitive enhancement therapy on employment outcomes in early schizophrenia: results from a 2-year randomized trial. Research on Social Work Practice. 2011;21(1):32–42.
    1. Eack SM, Greenwald DP, Hogarty SS, Keshavan MS. One-year durability of the effects of cognitive enhancement therapy on functional outcome in early schizophrenia. Schizophrenia Research. 2010;120(1–3):210–216.
    1. Wykes T, Spaulding WD. Thinking about the future cognitive remediation therapy-what works and could we do better? Schizophrenia Bulletin. 2011;37(supplement 2):S80–S90.
    1. Penn DL, Roberts DL, Combs D, Sterne A. The development of the social cognition and interaction training program for schizophrenia spectrum disorders. Psychiatric Services. 2007;58(4):449–451.
    1. Birchwood M, Smith J, Cochrane R, Wetton S, Copestake S. The Social Functioning Scale. The development and validation of a new scale of social adjustment for use in family intervention programmes with schizophrenic patients. British Journal of Psychiatry. 1990;157:853–859.
    1. Roberts DL, Penn DL. Social cognition and interaction training (SCIT) for outpatients with schizophrenia: a preliminary study. Psychiatry Research. 2009;166(2-3):141–147.
    1. Roberts DL, Penn DL, Labate D, Margolis SA, Sterne A. Transportability and feasibility of Social Cognition and Interaction Training (SCIT) in community settings. Behavioural and Cognitive Psychotherapy. 2010;38(1):35–47.
    1. Mazza M, Lucci G, Pacitti F, et al. Could schizophrenic subjects improve their social cognition abilities only with observation and imitation of social situations? Neuropsychological Rehabilitation. 2010;20(5):675–703.
    1. Gallese V. Mirror neurons, embodied simulation, and the neural basis of social identification. Psychoanalytic Dialogues. 2009;19(5):519–536.
    1. Kwon JH. Social Cognition Enhancement Rehabilitation Program. Seoul, Korea: Hakjisa; 2003.
    1. Choi KH, Kwon JH. Social cognition enhancement training for schizophrenia: a preliminary randomized controlled trial. Community Mental Health Journal. 2006;42(2):177–187.
    1. Roncone R, Mazza M, Frangou I, et al. Rehabilitation of theory of mind deficit in schizophrenia: a pilot study of metacognitive strategies in group treatment. Neuropsychological Rehabilitation. 2004;14(4):421–435.
    1. Wölwer W, Frommann N, Halfmann S, Piaszek A, Streit M, Gaebel W. Remediation of impairments in facial affect recognition in schizophrenia: efficacy and specificity of a new training program. Schizophrenia Research. 2005;80(2-3):295–303.
    1. Russell TA, Green MJ, Simpson I, Coltheart M. Remediation of facial emotion perception in schizophrenia: concomitant changes in visual attention. Schizophrenia Research. 2008;103(1–3):248–256.
    1. Bio DS, Gattaz WF. Vocational rehabilitation improves cognition and negative symptoms in schizophrenia. Schizophrenia Research. 2011;126(1–3):265–269.
    1. Vesterager L, Christensen TT, Olsen BB, et al. Cognitive training plus a comprehensive psychosocial programme (OPUS) versus the comprehensive psychosocial programme alone for patients with first-episode schizophrenia (the NEUROCOM trial): a study protocol for a centrally randomised, observer-blinded multi-centre clinical trial. Trials. 2011;12, article 35
    1. Breitborde NJK, Moreno FA, Mai-Dixon N, et al. Multifamily group psychoeducation and cognitive remediation for first-episode psychosis: a randomized controlled trial. BMC Psychiatry. 2011;11, article 9
    1. Brenner HD. The treatment of basic psychological dysfunctions from a systemic point of view. British Journal of Psychiatry. 1989;155(5):74–83.
    1. Brenner HD, Hodel B, Roder V, Corrigan P. Treatment of cognitive dysfunctions and behavioral deficits in schizophrenia. Schizophrenia Bulletin. 1992;18(1):21–26.
    1. Roder V, Mueller DR, Mueser KT, Brenner HD. Integrated psychological therapy (IPT) for schizophrenia: is it effective? Schizophrenia bulletin. 2006;32(supplement1):S81–93.
    1. Velligan DI, Diamond PM, Mintz J, et al. The use of individually tailored environmental supports to improve medication adherence and outcomes in schizophrenia. Schizophrenia Bulletin. 2008;34(3):483–493.
    1. Horan WP, Kern RS, Shokat-Fadai K, Sergi MJ, Wynn JK, Green MF. Social cognitive skills training in schizophrenia: an initial efficacy study of stabilized outpatients. Schizophrenia Research. 2009;107(1):47–54.
    1. Eack SM, Hogarty GE, Cho RY, et al. Neuroprotective effects of cognitive enhancement therapy against gray matter loss in early schizophrenia: results from a 2-year randomized controlled trial. Archives of General Psychiatry. 2010;67(7):674–682.
    1. Wexler BE, Anderson M, Fulbright RK, Gore JC. Preliminary evidence of improved verbal working memory performance and normalization of task-related frontal lobe activation in schizophrenia following cognitive exercises. American Journal of Psychiatry. 2000;157(10):1694–1697.
    1. Vinogradov S, Fisher M, Holland C, Shelly W, Wolkowitz O, Mellon SH. Is serum brain-derived neurotrophic factor a biomarker for cognitive enhancement in schizophrenia? Biological Psychiatry. 2009;66(6):549–553.

Source: PubMed

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