Residential exposure to polychlorinated biphenyls and organochlorine pesticides and risk of childhood leukemia

Mary H Ward, Joanne S Colt, Catherine Metayer, Robert B Gunier, Jay Lubin, Vonda Crouse, Marcia G Nishioka, Peggy Reynolds, Patricia A Buffler, Mary H Ward, Joanne S Colt, Catherine Metayer, Robert B Gunier, Jay Lubin, Vonda Crouse, Marcia G Nishioka, Peggy Reynolds, Patricia A Buffler

Abstract

Background: Incidence of childhood leukemia in industrialized countries rose significantly during 1975-2004, and the reasons for the increase are not understood.

Objectives: We used carpet dust as an exposure indicator to examine the risk of childhood leukemia in relation to residential exposure to persistent organochlorine chemicals: six polychlorinated biphenyl (PCB) congeners and the pesticides alpha- and gamma-chlordane, p,p'-DDT (dichlorodiphenyltrichloroethane), p,p'-DDE (dichlorodiphenyldichloroethylene), methoxychlor, and pentachlorophenol.

Methods: We conducted a population-based case-control study in 35 counties in northern and central California in 2001-2006. The study included 184 acute lymphocytic leukemia (ALL) cases 0-7 years of age and 212 birth certificate controls matched to cases by birth date, sex, race, and Hispanic ethnicity. We collected carpet dust samples from the room where the child spent the most time before diagnosis (similar date for controls) using a specialized vacuum.

Results: Detection of any PCB congener in the dust conferred a 2-fold increased risk of ALL [odds ratio (OR) = 1.97; 95% confidence interval (CI), 1.22-3.17]. Compared with those in the lowest quartile of total PCBs, the highest quartile was associated with about a 3-fold risk (OR = 2.78; 95% CI, 1.41-5.48), and the positive trend was significant (p = 0.017). Significant positive trends in ALL risk were apparent with increasing concentrations of PCB congeners 118, 138, and 153. We observed no significant positive associations for chlordane, DDT, DDE, methoxychlor, or pentachlorophenol. The associations with PCBs were stronger among non-Hispanic whites than among Hispanics despite similar distributions of PCB levels among controls in each racial/ethnic group.

Conclusions: Our findings suggest that PCBs, which are considered probable human carcinogens and cause perturbations of the immune system, may represent a previously unrecognized risk factor for childhood leukemia.

Keywords: childhood cancer; dust; leukemia; organochlorine compounds; pesticides; polychlorinated biphenyls.

Figures

Figure 1
Figure 1
Quantile–quantile plot of summed PCB concentrations for Hispanic, non-Hispanic (NH) white, and other racial groups. The fitted line, which is based on all measurement data, represents log-normally distributed data with geometric mean of 5.63 ng/g, geometric SD of 4.65 ng/g, and arithmetic mean of 16.23 ng/g.

References

    1. Bradman A, Fenster L, Sjodin A, Jones RS, Patterson DG, Jr, Eskenazi B. Polybrominated diphenyl ether levels in the blood of pregnant women living in an agricultural community in California. Environ Health Perspect. 2007;115:71–74.
    1. Bradman MA, Harnly ME, Draper W, Seidel S, Teran S, Wakeham D, et al. Pesticide exposures to children from California’s Central Valley: results of a pilot study. J Expo Anal Environ Epidemiol. 1997;7:217–234.
    1. Brown LM, Blair A, Gibson R, Everett GD, Cantor KP, Schuman LM, et al. Pesticide exposures and other agricultural risk factors for leukemia among men in Iowa and Minnesota. Cancer Res. 1990;50:6585–6591.
    1. Buffler PA, Kwan ML, Reynolds P, Urayama KY. Environmental and genetic risk factors for childhood leukemia: appraising the evidence. Cancer Invest. 2005;23:60–75.
    1. Butte W, Heinzow B. Pollutants in house dust as indicators of indoor contamination. Rev Environ Contam Toxicol. 2002;175:1–46.
    1. Calabrese EJ, Barnes R, Stanek EJ, III, Pastides H, Gilbert CE, Veneman P, et al. How much soil do young children ingest: an epidemiologic study. Regul Toxicol Pharmacol. 1989;10:123–137.
    1. Chang JS, Selvin S, Metayer C, Crouse V, Golembesky A, Buffler PA. Parental smoking and the risk of childhood leukemia. Am J Epidemiol. 2006;163:1091–1100.
    1. Colt JS, Gunier RB, Metayer C, Nishioka MG, Bell EM, Reynolds P, et al. Household vacuum cleaners vs. the high-volume surface sampler for collection of carpet dust samples in epidemiologic studies of children. Environ Health. 2008;7:6. doi: 10.1186/1476-069X-7-6. [Online 21 February 2008]
    1. Colt JS, Severson RK, Lubin J, Rothman N, Camann D, Davis S, et al. Organochlorines in carpet dust and non-Hodgkin lymphoma. Epidemiology. 2005;16:516–525.
    1. Dalmasso P, Pastore G, Zuccolo L, Maule MM, Pearce N, Merletti F, et al. Temporal trends in the incidence of childhood leukemia, lymphomas and solid tumors in northwest Italy, 1967–2001. A report of the Childhood Cancer Registry of Piedmont. Haematologica. 2005;90:1197–1204.
    1. Daniels JL, Olshan AF, Savitz DA. Pesticides and childhood cancers. Environ Health Perspect. 1997;105:1068–1077.
    1. Davis S, Waller P, Buschbom R, Ballou J, White P. Quantitative estimates of soil ingestion in normal children between the ages of 2 and 7 years: population-based estimates using aluminum, silicon, and titanium as soil tracer elements. Arch Environ Health. 1990;45:112–122.
    1. De Roos AJ, Hartge P, Lubin JH, Colt JS, Davis S, Cerhan JR, et al. Persistent organochlorine chemicals in plasma and risk of non-Hodgkin’s lymphoma. Cancer Res. 2005;65:11214–11226.
    1. Engel LS, Lan Q, Rothman N. Polychlorinated biphenyls and non-Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev. 2007;16:373–376.
    1. Epstein SS, Ozonoff D. Leukemias and blood dyscrasias following exposure to chlordane and heptachlor. Teratog Carcinog Mutagen. 1987;7:527–540.
    1. Flower KB, Hoppin JA, Lynch CF, Blair A, Knott C, Shore DL, et al. Cancer risk and parental pesticide application in children of Agricultural Health Study participants. Environ Health Perspect. 2004;112:631–635.
    1. Furst P. Dioxins, polychlorinated biphenyls and other organohalogen compounds in human milk. Levels, correlations, trends and exposure through breastfeeding. Mol Nutr Food Res. 2006;50:922–933.
    1. Guvenius DM, Aronsson A, Ekman-Ordeberg G, Bergman A, Noren K. Human prenatal and postnatal exposure to polybrominated diphenyl ethers, polychlorinated biphenyls, polychlorobiphenylols, and pentachlorophenol. Environ Health Perspect. 2003;111:1235–1241.
    1. Harper N, Connor K, Steinberg M, Safe S. Immuno-suppressive activity of polychlorinated biphenyl mixtures and congeners: nonadditive (antagonistic) interactions. Fundam Appl Toxicol. 1995;27:131–139.
    1. Herrick RF, Lefkowitz DJ, Weymouth GA. Soil contamination from PCB-containing buildings. Environ Health Perspect. 2007;115:173–175.
    1. Herrick RF, McClean MD, Meeker JD, Baxter LK, Weymouth GA. An unrecognized source of PCB contamination in schools and other buildings. Environ Health Perspect. 2004;112:1051–1053.
    1. Hertz-Picciotto I, Park HY, Dostal M, Kocan A, Trnovec T, Sram R. Prenatal exposures to persistent and nonpersistent organic compounds and effects on immune system development. Basic Clin Pharmacol Toxicol. 2008;102:146–154.
    1. Hooper K, She J, Sharp M, Chow J, Jewell N, Gephart R, et al. Depuration of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) in breast milk from California first-time mothers (primiparae) Environ Health Perspect. 2007;115:1271–1275.
    1. Infante PF, Epstein SS, Newton WA., Jr Blood dyscrasias and childhood tumors and exposure to chlordane and heptachlor. Scand J Work Environ Health. 1978;4:137–150.
    1. Infante-Rivard C, Weichenthal S. Pesticides and childhood cancer: an update of Zahm and Ward’s 1998 review. J Toxicol Environ Health B Crit Rev. 2007;10:81–99.
    1. International Agency for Research on Cancer. Polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans. IARC Monogr Eval Carcinog Risks Hum. 1997;69:1–631.
    1. Kroll ME, Draper GJ, Stiller CA, Murphy MF. Childhood leukemia incidence in Britain, 1974–2000: time trends and possible relation to influenza epidemics. J Natl Cancer Inst. 2006;98:417–420.
    1. Laden F, Neas LM, Spiegelman D, Hankinson SE, Willett WC, Ireland K, et al. Predictors of plasma concentrations of DDE and PCBs in a group of U.S. women. Environ Health Perspect. 1999;107:75–81.
    1. Lanphear BP, Weitzman M, Winter NL, Eberly S, Yakir B, Tanner M, et al. Lead-contaminated house dust and urban children’s blood lead levels. Am J Public Health. 1996;86:1416–1421.
    1. Levin M, Morsey B, Mori C, Nambiar PR, De Guise S. Non-coplanar PCB-mediated modulation of human leukocyte phagocytosis: a new mechanism for immunotoxicity. J Toxicol Environ Health A. 2005;68:1977–1993.
    1. Lubin JH, Colt JS, Camann D, Davis S, Cerhan JR, Severson RK, et al. Epidemiologic evaluation of measurement data in the presence of detection limits. Environ Health Perspect. 2004;112:1691–1696.
    1. Ma X, Buffler PA, Layefsky M, Does MB, Reynolds P. Control selection strategies in case-control studies of childhood diseases. Am J Epidemiol. 2004;159:915–921.
    1. Ma X, Buffler PA, Wiemels JL, Selvin S, Metayer C, Loh M, et al. Ethnic difference in daycare attendance, early infections, and risk of childhood acute lymphoblastic leukemia. Cancer Epidemiol Biomarkers Prev. 2005;14:1928–1934.
    1. Monge P, Wesseling C, Guardado J, Lundberg I, Ahlbom A, Cantor KP, et al. Parental occupational exposure to pesticides and the risk of childhood leukemia in Costa Rica. Scand J Work Environ Health. 2007;33:293–303.
    1. Nishi M, Miyake H, Takeda T, Shimada M. Epidemiology of childhood leukemia in Hokkaido, Japan. Int J Cancer. 1996;67:323–326.
    1. Purdue MP, Hoppin JA, Blair A, Dosemeci M, Alavanja MC. Occupational exposure to organochlorine insecticides and cancer incidence in the Agricultural Health Study. Int J Cancer. 2007;120:642–649.
    1. Ries LAG, Melbert D, Krapcho M, Mariotto A, Miller BA, Freuer EJ, et al. SEER Cancer Statistics Review: 1975–2004. Bethesda, MD: National Cancer Institute; 2004.
    1. Ross JA, Spector LG. Cancers in children. In: Schottenfeld D, Fraumeni JF Jr, editors. Cancer Epidemiology and Prevention. New York: Oxford University Press; 2006. pp. 1251–1268.
    1. Rudel RA, Seryak LM, Brody JG. PCB-containing wood floor finish is a likely source of elevated PCBs in residents’ blood, household air and dust: a case study of exposure. Environ Health. 2008;7:2. doi: 10.1186/1476-069X-7-2. [Online 17 January 2008]
    1. Safe S. Toxicology, structure-function relationship, and human and environmental health impacts of polychlorinated biphenyls: progress and problems. Environ Health Perspect. 1993;100:259–268.
    1. Schecter A, Papke O, Tung KC, Joseph J, Harris TR, Dahlgren J. Polybrominated diphenyl ether flame retardants in the U.S. population: current levels, temporal trends, and comparison with dioxins, dibenzofurans, and polychlorinated biphenyls. J Occup Environ Med. 2005;47:199–211.
    1. Scheele J, Teufel M, Niessen KH. Chlorinated hydrocarbons in the bone marrow of children: studies on their association with leukaemia. Eur J Pediatr. 1992;151:802–805.
    1. She J, Holden A, Sharp M, Tanner M, Williams-Derry C, Hooper K. Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) in breast milk from the Pacific Northwest. Chemosphere. 2007;67:S307–S317.
    1. Thornton I, Davies DJ, Watt JM, Quinn MJ. Lead exposure in young children from dust and soil in the United Kingdom. Environ Health Perspect. 1990;89:55–60.
    1. Tryphonas H. Immunotoxicity of polychlorinated biphenyls: present status and future considerations. Exp Clin Immunogenet. 1994;11:149–162.
    1. U.S. Census Bureau. [[accessed 14 November 2007].];Census 2000 Urban and Rural Classification [Data file] . 2002 Available .
    1. U.S. Environmental Protection Agency. [[accessed 15 September 2008].];Technical Factsheet on Polychlorinated Biphenyls (PCBs) . 2005 Available .
    1. Wilson NK, Chuang JC, Lyu C. Levels of persistent organic pollutants in several child day care centers. J Expo Anal Environ Epidemiol. 2001;11:449–458.
    1. Wolff MS, Camann D, Gammon M, Stellman SD. Proposed PCB congener groupings for epidemiological studies. Environ Health Perspect. 1997;105:13–14.
    1. Zahm SH, Ward MH. Pesticides and childhood cancer. Environ Health Perspect. 1998;106(suppl 3):893–908.

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