Frequency of gestational diabetes mellitus at collaborating centers based on IADPSG consensus panel-recommended criteria: the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study
David A Sacks, David R Hadden, Michael Maresh, Chaicharn Deerochanawong, Alan R Dyer, Boyd E Metzger, Lynn P Lowe, Donald R Coustan, Moshe Hod, Jeremy J N Oats, Bengt Persson, Elisabeth R Trimble, HAPO Study Cooperative Research Group, David A Sacks, David R Hadden, Michael Maresh, Chaicharn Deerochanawong, Alan R Dyer, Boyd E Metzger, Lynn P Lowe, Donald R Coustan, Moshe Hod, Jeremy J N Oats, Bengt Persson, Elisabeth R Trimble, HAPO Study Cooperative Research Group
Abstract
Objective: To report frequencies of gestational diabetes mellitus (GDM) among the 15 centers that participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study using the new International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria.
Research design and methods: All participants underwent a 75-g oral glucose tolerance test between 24 and 32 weeks' gestation. GDM was retrospectively classified using the IADPSG criteria (one or more fasting, 1-h, or 2-h plasma glucose concentrations equal to or greater than threshold values of 5.1, 10.0, or 8.5 mmol/L, respectively).
Results: Overall frequency of GDM was 17.8% (range 9.3-25.5%). There was substantial center-to-center variation in which glucose measures met diagnostic thresholds.
Conclusions: Although the new diagnostic criteria for GDM apply globally, center-to-center differences occur in GDM frequency and relative diagnostic importance of fasting, 1-h, and 2-h glucose levels. This may impact strategies used for the diagnosis of GDM.
References
- Metzger BE, Lowe LP, Dyer AR, et al. ; HAPO Study Cooperative Research Group. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 2008;358:1991–2002
- HAPO Study Cooperative Research Group. Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: associations with neonatal anthropometrics. Diabetes 2009;58:453–459
- Metzger BE, Gabbe SG, Persson B, et al. ; International Association of Diabetes and Pregnancy Study Groups Consensus Panel. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care 2010;33:676–682
Source: PubMed