Comparison of contact lens and intraocular lens correction of monocular aphakia during infancy: a randomized clinical trial of HOTV optotype acuity at age 4.5 years and clinical findings at age 5 years
Infant Aphakia Treatment Study Group, Scott R Lambert, Michael J Lynn, E Eugenie Hartmann, Lindreth DuBois, Carolyn Drews-Botsch, Sharon F Freedman, David A Plager, Edward G Buckley, M Edward Wilson, Scott R Lambert, Lindreth DuBois, Buddy Russell, Michael Ward, Robert Hardy, Eileen Birch, Ken Cheng, Richard Hertle, Craig Kollman, Marshalyn Yeargin-Allsopp, Cyd McDowell, Donald F Everett, Michael Lynn, Betsy Bridgman, Marianne Celano, Julia Cleveland, George Cotsonis, Carey Drews-Botsch, Nana Freret, Lu Lu, Seegar Swanson, Thandeka Tutu-Gxashe, Claudio Busettini, Samuel Hayley, Joost Felius, Allen Beck, Donald F Everett, Scott R Lambert, Edward G Buckley, David A Plager, M Edward Wilson, Michael Lynn, Lindreth DuBois, Carolyn Drews-Botsch, E Eugenie Hartmann, Donald F Everett, E Eugenie Hartmann, Anna K Carrigan, Clara Edwards, M Edward Wilson, Margaret Bozic, Deborah K Vanderveen, Theresa A Mansfield, Kathryn Bisceglia Miller, Stephen P Christiansen, Erick D Bothun, Ann Holleschau, Jason Jedlicka, Patricia Winters, Jacob Lang, Elias I Traboulsi, Susan Crowe, Heather Hasley Cimino, Kimberly G Yen, Maria Castanes, Alma Sanchez, Shirley York, Scott R Lambert, Amy K Hutchinson, Lindreth DuBois, Rachel Robb, Marla J Shainberg, David T Wheeler, Ann U Stout, Paula Rauch, Kimberly Beaudet, Pam Berg, Edward G Buckley, Sharon F Freedman, Lois Duncan, B W Phillips, John T Petrowski, David Morrison, Sandy Owings, Ron Biernacki, Christine Franklin, David A Plager, Daniel E Neely, Michele Whitaker, Donna Bates, Dana Donaldson, Stacey Kruger, Charlotte Tibi, Susan Vega, David R Weakley, David R Stager Jr, Joost Felius, Clare Dias, Debra L Sager, Todd Brantley, Faruk Orge, Infant Aphakia Treatment Study Group, Scott R Lambert, Michael J Lynn, E Eugenie Hartmann, Lindreth DuBois, Carolyn Drews-Botsch, Sharon F Freedman, David A Plager, Edward G Buckley, M Edward Wilson, Scott R Lambert, Lindreth DuBois, Buddy Russell, Michael Ward, Robert Hardy, Eileen Birch, Ken Cheng, Richard Hertle, Craig Kollman, Marshalyn Yeargin-Allsopp, Cyd McDowell, Donald F Everett, Michael Lynn, Betsy Bridgman, Marianne Celano, Julia Cleveland, George Cotsonis, Carey Drews-Botsch, Nana Freret, Lu Lu, Seegar Swanson, Thandeka Tutu-Gxashe, Claudio Busettini, Samuel Hayley, Joost Felius, Allen Beck, Donald F Everett, Scott R Lambert, Edward G Buckley, David A Plager, M Edward Wilson, Michael Lynn, Lindreth DuBois, Carolyn Drews-Botsch, E Eugenie Hartmann, Donald F Everett, E Eugenie Hartmann, Anna K Carrigan, Clara Edwards, M Edward Wilson, Margaret Bozic, Deborah K Vanderveen, Theresa A Mansfield, Kathryn Bisceglia Miller, Stephen P Christiansen, Erick D Bothun, Ann Holleschau, Jason Jedlicka, Patricia Winters, Jacob Lang, Elias I Traboulsi, Susan Crowe, Heather Hasley Cimino, Kimberly G Yen, Maria Castanes, Alma Sanchez, Shirley York, Scott R Lambert, Amy K Hutchinson, Lindreth DuBois, Rachel Robb, Marla J Shainberg, David T Wheeler, Ann U Stout, Paula Rauch, Kimberly Beaudet, Pam Berg, Edward G Buckley, Sharon F Freedman, Lois Duncan, B W Phillips, John T Petrowski, David Morrison, Sandy Owings, Ron Biernacki, Christine Franklin, David A Plager, Daniel E Neely, Michele Whitaker, Donna Bates, Dana Donaldson, Stacey Kruger, Charlotte Tibi, Susan Vega, David R Weakley, David R Stager Jr, Joost Felius, Clare Dias, Debra L Sager, Todd Brantley, Faruk Orge
Abstract
Importance: The efficacy and safety of primary intraocular lens (IOL) implantation during early infancy is unknown.
Objective: To compare the visual outcomes of patients optically corrected with contact lenses vs IOLs following unilateral cataract surgery during early infancy.
Design, setting, and participants: The Infant Aphakia Treatment Study is a randomized clinical trial with 5 years of follow-up that involved 114 infants with unilateral congenital cataracts at 12 sites. A traveling examiner assessed visual acuity at age 4.5 years.
Interventions: Cataract surgery with or without primary IOL implantation. Contact lenses were used to correct aphakia in patients who did not receive IOLs. Treatment was determined through random assignment.
Main outcomes and measures: HOTV optotype visual acuity at 4.5 years of age.
Results: The median logMAR visual acuity was not significantly different between the treated eyes in the 2 treatment groups (both, 0.90 [20/159]; P = .54). About 50% of treated eyes in both groups had visual acuity less than or equal to 20/200. Significantly more patients in the IOL group had at least 1 adverse event after cataract surgery (contact lens, 56%; IOL, 81%; P = .02). The most common adverse events in the IOL group were lens reproliferation into the visual axis, pupillary membranes, and corectopia. Glaucoma/glaucoma suspect occurred in 35% of treated eyes in the contact lens group vs 28% of eyes in the IOL group (P = .55). Since the initial cataract surgery, significantly more patients in the IOL group have had at least 1 additional intraocular surgery (contact lens, 21%; IOL, 72%; P < .001).
Conclusions and relevance: There was no significant difference between the median visual acuity of operated eyes in children who underwent primary IOL implantation and those left aphakic. However, there were significantly more adverse events and additional intraoperative procedures in the IOL group. When operating on an infant younger than 7 months of age with a unilateral cataract, we recommend leaving the eye aphakic and focusing the eye with a contact lens. Primary IOL implantation should be reserved for those infants where, in the opinion of the surgeon, the cost and handling of a contact lens would be so burdensome as to result in significant periods of uncorrected aphakia.
Trial registration: clinicaltrials.gov Identifier: NCT00212134
Conflict of interest statement
Conflict of Interest Disclosures: None reported
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Source: PubMed