The obstetric and neonatal implications of a low value on the 50-g glucose screening test
Kimberly K Ma, Lisa Mele, Mark B Landon, Catherine Y Spong, Susan M Ramin, Brian Casey, Ronald J Wapner, Michael W Varner, Dwight J Rouse, John M Thorp Jr, Anthony Sciscione, Patrick Catalano, Margaret Harper, George Saade, Steve N Caritis, Yoram Sorokin, Alan M Peaceman, Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, Kimberly K Ma, Lisa Mele, Mark B Landon, Catherine Y Spong, Susan M Ramin, Brian Casey, Ronald J Wapner, Michael W Varner, Dwight J Rouse, John M Thorp Jr, Anthony Sciscione, Patrick Catalano, Margaret Harper, George Saade, Steve N Caritis, Yoram Sorokin, Alan M Peaceman, J Tolosa, L Davis, E Lairson, C Cromett, C Naze, M Blaser, K Leveno, L Moseley, J Gold, D Bradford, L Fay, M Garcia, F Capellan, M Miodovnik, F Malone, S Bousleiman, H Husami, V Carmona, N Fredericks, E Gantioqui, B Greenspan, M Williams, K Anderson, P Ashby, S McAllister, S Quinn, F Castinella, A Guzman, J Steiner, J Parker, J Sheppard, J Tisdale, A Northen, W Andrews, M Carpenter, D Catlow, D Allard, M Seebeck, J Tillinghast, J Iams, F Johnson, C Latimer, E Weinandy, B Maselli, K Dorman, S Brody, S Timlin, J Bernhardt, M Hoffman, E Guzman, M Talucci, T Grossman, C Perez, L Zeghibe, P Tabangin, B Mercer, B Stetzer, C Milluzzi, W Dalton, S Pichette, M Swain, P Meis, J White, L Gilstrap, K Cannon, J Martinez, D Dusek, J Moss, J Brandon, A Jackson, G Hankins, D Sharp, M Bickus, H Birkland, M Cotroneo, N Cuddy, G Norman, P Lockhart, S Blackwell, L Quast, P Simon, G Mallett, E Thom, J Zachary, B Getachew, C Cobb, L Leuchtenburg, S Gilbert, S Tolivaisa, K Howell, Kimberly K Ma, Lisa Mele, Mark B Landon, Catherine Y Spong, Susan M Ramin, Brian Casey, Ronald J Wapner, Michael W Varner, Dwight J Rouse, John M Thorp Jr, Anthony Sciscione, Patrick Catalano, Margaret Harper, George Saade, Steve N Caritis, Yoram Sorokin, Alan M Peaceman, Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, Kimberly K Ma, Lisa Mele, Mark B Landon, Catherine Y Spong, Susan M Ramin, Brian Casey, Ronald J Wapner, Michael W Varner, Dwight J Rouse, John M Thorp Jr, Anthony Sciscione, Patrick Catalano, Margaret Harper, George Saade, Steve N Caritis, Yoram Sorokin, Alan M Peaceman, J Tolosa, L Davis, E Lairson, C Cromett, C Naze, M Blaser, K Leveno, L Moseley, J Gold, D Bradford, L Fay, M Garcia, F Capellan, M Miodovnik, F Malone, S Bousleiman, H Husami, V Carmona, N Fredericks, E Gantioqui, B Greenspan, M Williams, K Anderson, P Ashby, S McAllister, S Quinn, F Castinella, A Guzman, J Steiner, J Parker, J Sheppard, J Tisdale, A Northen, W Andrews, M Carpenter, D Catlow, D Allard, M Seebeck, J Tillinghast, J Iams, F Johnson, C Latimer, E Weinandy, B Maselli, K Dorman, S Brody, S Timlin, J Bernhardt, M Hoffman, E Guzman, M Talucci, T Grossman, C Perez, L Zeghibe, P Tabangin, B Mercer, B Stetzer, C Milluzzi, W Dalton, S Pichette, M Swain, P Meis, J White, L Gilstrap, K Cannon, J Martinez, D Dusek, J Moss, J Brandon, A Jackson, G Hankins, D Sharp, M Bickus, H Birkland, M Cotroneo, N Cuddy, G Norman, P Lockhart, S Blackwell, L Quast, P Simon, G Mallett, E Thom, J Zachary, B Getachew, C Cobb, L Leuchtenburg, S Gilbert, S Tolivaisa, K Howell
Abstract
Objective: To assess the relationship between a low 50-g 1-hour glucose loading test (GLT) and maternal and neonatal outcomes in women without diabetes.
Study design: This was a secondary analysis of a multicenter observational cohort from a randomized trial of treatment for mild gestational diabetes. Maternal and neonatal outcomes were compared between women with GLT values < 90 mg/dL and those with results 90 to 119 mg/dL.
Results: Of 436 enrolled women, 297 (68.1%) had a GLT result of 90 to 119 mg/dL and 139 (31.9%) had a result of < 90 mg/dL. There was a lower incidence of neonatal hypoglycemia in those with a GLT < 90 mg/dL (5.7% versus 16.5%, p = 0.006). Other outcomes were not associated with test results.
Conclusion: A GLT result < 90 mg/dL compared with 90 to 119 mg/dL is associated with a lower risk of neonatal hypoglycemia, but no other significant findings.
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Source: PubMed