Intragastric bacterial activity and nitrosation before, during, and after treatment with omeprazole

B K Sharma, I A Santana, E C Wood, R P Walt, M Pereira, P Noone, P L Smith, C L Walters, R E Pounder, B K Sharma, I A Santana, E C Wood, R P Walt, M Pereira, P Noone, P L Smith, C L Walters, R E Pounder

Abstract

Ten healthy volunteers were studied before, during, and after treatment with omeprazole 30 mg daily for two weeks. On the 14th night mean nocturnal (2100-0700) intragastric acidity was significantly decreased by 75% (p less than 0.001). At 0700, 22 hours after the last dose of omeprazole, there were significant increases in the bacterial count and the nitrite and N-nitrosamine concentrations in the gastric juice (p less than 0.001). Three days later these changes had resolved. Short term treatment of healthy volunteers with omeprazole is associated with a short lived increase in the gastric bacterial flora, with endogenous production of N-nitroso compounds.

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Source: PubMed

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