Successful treatment of refractory wart with a topical activated vitamin d in a renal transplant recipient

Luciano Moscarelli, Filomena Annunziata, Anduela Mjeshtri, Nunzia Paudice, Aris Tsalouchos, Maria Zanazzi, Elisabetta Bertoni, Luciano Moscarelli, Filomena Annunziata, Anduela Mjeshtri, Nunzia Paudice, Aris Tsalouchos, Maria Zanazzi, Elisabetta Bertoni

Abstract

Warts are benign proliferations of the skin and mucosa caused by infection with human papillomavirus. They are commonly treated with destructive modalities such as cryotherapy with liquid nitrogen, local injection of bleomycin, electrocoagulation, topical application of glutaraldehyde, and local and systemic interferon-β therapy. These treatment modalities often cause pain and sometimes scarring or pigmentation after treatment. We herein report a case with a right index finger wart, which was successfully treated with a topical activated vitamin D.

Figures

Figure 1
Figure 1
Refractory wart on right index finger (a). It was treated using local application of calcitriol 0.5 μg solution and disappeared completely three months later (b).

References

    1. Sterling JC, Handfield-Jones S, Hudson PM. Guidelines for the management of cutaneous warts. British Journal of Dermatology. 2001;144(1):4–11.
    1. Allam JP, Hagemann T, Bieber T, Novak N. Successful treatment of therapy-resistant plantar verrucae vulgares with systemic interferon-β . Journal of Dermatology. 2004;31(7):582–583.
    1. Gibbs S, Harvey I, Sterling J, Stark R. Local treatments for cutaneous warts: systematic review. British Medical Journal. 2002;325(7362):461–464.
    1. Blohme I, Larko O. Skin lesions in renal transplant patients after 10-23 years of immunosuppressive therapy. Acta Dermato-Venereologica. 1990;70(6):491–494.
    1. Liu PT, Stenger S, Li H, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006;311(5768):1770–1773.
    1. Barker JNWN, Ashton RE, Marks R, Harris RI, Berth-Jones J. Topical maxacalcitol for the treatment of psoriasis vulgaris: a placebo- controlled, double-blind, dose-finding study with active comparator. British Journal of Dermatology. 1999;141(2):274–278.
    1. Majewski S, Skopinska M, Bollag W, Jablonska S. Combination of isotretinoin and calcitriol for precancerous and cancerous skin lesions. The Lancet. 1994;344(8935):1510–1511.
    1. Egawa K, Ono T. Topical vitamin D3 derivatives for recalcitrant warts in three immunocompromised patients. British Journal of Dermatology. 2004;150(2):374–376.
    1. Osborne JE, Hutchinson PE. Vitamin D and systemic cancer: is this relevant to malignant melanoma? British Journal of Dermatology. 2002;147(2):197–213.

Source: PubMed

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