A new therapeutic horizon in diaper dermatitis: Novel agents with novel action

Adelaide A Hebert, Adelaide A Hebert

Abstract

Objective: This review looks at novel combinations of topical agents (i.e., zinc gluconate, zinc oxide, dexpanthenol, and taurine) that target a combination of mechanisms in diaper dermatitis.

Methods: A literature search of published studies was conducted using the search terms "diaper dermatitis", "treatment of diaper dermatitis in infants", "treatment of diaper dermatitis in adults", "nonsteroidal", "nonantibiotic", "antiinflammatory", "moisturizer", and "treatment for irritation". A total of 207 related articles were screened, and those categorized as clinical trials and reviews were studied and compared. Articles with common themes were categorized, summarized, and presented herein.

Results: Diaper dermatitis, also referred to as diaper rash, napkin dermatitis, and nappy rash, is the most common skin eruption in infants and toddlers. In the last several years, there have been several technologic advances in diaper design to lessen the severity of diaper dermatitis symptoms. However, due to the unique environment of the diaper area, children and adults continue to have recurring symptoms of diaper dermatitis. Both commercially available products and certain home remedies are considered effective for managing sensitive and delicate skin in the diaper area. These topical agents create a protective barrier over the skin and reduce the impact of external irritants, which cause the reddening and burning sensation often associated with diaper dermatitis.

Conclusion: A range of therapeutic strategies for preventing and controlling diaper dermatitis are summarized in this manuscript.

Keywords: Dexpanthenol; Diaper dermatitis; Novel treatment; Taurine; Zinc gluconate; Zinc oxide.

© 2021 Published by Elsevier Inc. on behalf of Women's Dermatologic Society.

Figures

Fig. 1
Fig. 1
Pathophysiologic quaternity of diaper dermatitis.
Fig. 2
Fig. 2
Efficacy of Relizema baby care and Relizema spray and go in the reduction of skin erythema in infants and toddlers with diaper dermatitis after 2 weeks of treatment. The studies confirmed the products’ efficacy with very good skin acceptability after application of both products at every diaper change for 28 consecutive days ± 2 days in infants and toddlers age 3 to 36 months with slight skin irritation of the nappy area. The pediatrician examined the treated zone (at the beginning of the study and after 2 and 4 weeks).

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Source: PubMed

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